DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4587 and Cacna2d1

DIOPT Version :9

Sequence 1:NP_001188817.2 Gene:CG4587 / 34921 FlyBaseID:FBgn0028863 Length:1271 Species:Drosophila melanogaster
Sequence 2:XP_011248046.1 Gene:Cacna2d1 / 12293 MGIID:88295 Length:1110 Species:Mus musculus


Alignment Length:1315 Identity:321/1315 - (24%)
Similarity:551/1315 - (41%) Gaps:310/1315 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 CFVAIVLGVLIFKMHIFVAFADQDEDIPHNEVRNWALKFGVDLWEFGRQ---FTKMNEIKSRFKD 69
            |.:|:.|  .:|:..:....:::....|.. :::|..|...||....:.   .|::.:|..::: 
Mouse     5 CLLALTL--TLFQSGLIGPSSEEPFPSPVT-IKSWVDKMQEDLVTLAKTASGVTQLADIYEKYQ- 65

  Fly    70 NDIEVKRKDGIILLRELAA-EVKNFMDFKRNAVMRLMDSAEQAALSELEGQGQAESPMGGQQHYD 133
             |:.....:....|.|:|| :::..:..:..|::||...||           :.::....::.:.
Mouse    66 -DLYTVEPNNARQLVEIAARDIEKLLSNRSKALVRLAMEAE-----------KVQAAHQWREDFA 118

  Fly   134 ARRINEYNADGKL-------ADGARHM------DIRFMRRFERLPVNLSLSSILVPHGVDLDEPD 185
            :..:..|||...|       ..|::.:      |..|.|:     ::...:::.:|..:......
Mouse   119 SNEVVYYNAKDDLDPERNESEPGSQRIKPVFIEDANFGRQ-----ISYQHAAVHIPTDIYEGSTI 178

  Fly   186 VKSALQWSGHLDPLFQNNLEQDPALSWQYFGSSTGFLRRFPGTAWPPEGSKGSKL-IHDFRTHNW 249
            |.:.|.|:..||.:|:.|.::||.|.||.|||:||..|.:|.:.|.......:|: ::|.|...|
Mouse   179 VLNELNWTSALDEVFKRNRDEDPTLLWQVFGSATGLARYYPASPWVDNSRTPNKIDLYDVRRRPW 243

  Fly   250 FVQAASSPKDIMILLDASSSMTEKSFDLGMATAFNILDTLGEDDFVNLITFSEVVKTPVPCFKDR 314
            ::|.|:||||::||:|.|.|::..:..|...:...:|:||.:|||||:.:|:...: .|.||: .
Mouse   244 YIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQ-DVSCFQ-H 306

  Fly   315 MVRATPDNIQEIKSAVKAIKLQDTANFTAGLEYAFSLLHKYNQSGAGSQCNQAIMLITESTSESH 379
            :|:|...|.:.:|.||..|..:...::..|..:||..|..||.|.|  .||:.|||.|:...|..
Mouse   307 LVQANVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQLLNYNVSRA--NCNKIIMLFTDGGEERA 369

  Fly   380 KDVIKQYNWPHMPVRIFTYLIGSDSGSRSNLHDMACSNKGFFVQINDYDEARRKVIDYALVMARP 444
            :::..:|| ....||:||:.:|..:..|..:..|||.|||::.:|......|....:|..|:.||
Mouse   370 QEIFAKYN-KDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIRINTQEYLDVLGRP 433

  Fly   445 MIMY-QADHPVHWSPVFVAGKSGGLGRDSEYQRRLVTTVSTPVFDRRNHSVRVANL-----LGVV 503
            |::. .....|.|:.|::.....|          ||.|.:.|||:....|....||     |||:
Mouse   434 MVLAGDKAKQVQWTNVYLDALELG----------LVITGTLPVFNVTGQSENKTNLKNQLILGVM 488

  Fly   504 GTDVPIEEIRKVIPQHKLGPNGYSFIVDNNGRVLYHPDLRPLGDANQYIDQLKPKYASVDITELE 568
            |.||.:|:|:::.|:..|.||||.|.:|.||.||.||:|:|           ||  ..|.|..:.
Mouse   489 GVDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQP-----------KP--IGVGIPTIN 540

  Fly   569 L----PETEFGNNNEPI-------EINKNLLNEMRGDMIKPKEGETEFTVMNHYDDSKRVSTRTH 622
            |    |..:...:.||:       |:...:..|:|..||..:.||..|..:....|.:.:.....
Mouse   541 LRKRRPNVQNPKSQEPVTLDFLDAELENEIKVEIRNKMIDGESGEKTFRTLVKSQDERYIDKGNR 605

  Fly   623 RYFYGPIEDTPFTLAIVLPE------KYGSHEFVSQQEIRHSRNNVTEYFKGDNWRVHPDWVYCE 681
            .|.:.|:..|.::||:|||.      |....|.::|...:..:...:|..|.||:          
Mouse   606 TYTWTPVNGTDYSLALVLPTYSFYYIKAKLEETITQARSKKGKMKDSETLKPDNF---------- 660

  Fly   682 YNSVSDLEKERESSG-------EYSSRDQEPSFGSPEEQVLHFLSRAGRPGWKWMSVRPKSPQPH 739
                       |.||       ||.: |.:|| .:..|.:|:|.....|          |:|   
Mouse   661 -----------EESGYTFIAPREYCN-DLKPS-DNNTEFLLNFNEFIDR----------KTP--- 699

  Fly   740 HNMHSGSNGGNAPGSSHFGSQHQSSQGSRKAEPYFCDRALLQSLVRDAMVTDGLDRNTTGSSSGK 804
                      |.|.                     |:..|:..::.||..|:.|.:|....    
Mouse   700 ----------NNPS---------------------CNTDLINRILLDAGFTNELVQNYWSK---- 729

  Fly   805 EDKHPIATLMAILKRQGYQKFV--VATSFVATRSGLLRWIDHVKRPEDTPEPHFSEDNVRAMDTS 867
                              ||.:  |...||.|..|:.|     ..|::..|..  ::|....:.|
Mouse   730 ------------------QKNIKGVKARFVVTDGGITR-----VYPKEAGENW--QENPETYEDS 769

  Fly   868 WYKRAIDQHSVEPDSFVYSVPF--GSGYAIKSNATLVTASHAIFVEHRGHKAAAGVVGLQFQHDS 930
            :|||::|.     |::|::.|:  .||.....:..:|:.:..::::.:..|.|  |||::...:|
Mouse   770 FYKRSLDN-----DNYVFTAPYFNKSGPGAYESGIMVSKAVELYIQGKLLKPA--VVGIKIDVNS 827

  Fly   931 LAKHF--INITSACTG-MTGCKRTCASDNLDCYVLDNSGFVIISEEMEHT---GKFFGQIDGTIM 989
            ..::|  .:|...|.| :..|||.  ||.:||.:||:.||::::...::|   |:|||:||.::|
Mouse   828 WIENFTKTSIRDPCAGPVCDCKRN--SDVMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPSMM 890

  Fly   990 DSLVQDRIYKRVTVNDYQGVCSDADNPYTAAG-------GILKPNRLGSWFFNHLLALSAAW--- 1044
            ..||...:|......|||.||.....|...||       .|....::|.|      |.:|||   
Mouse   891 RHLVNISLYAFNKSYDYQSVCDPGAAPKQGAGHRSAYVPSIADILQIGWW------ATAAAWSIL 949

  Fly  1045 ----LSL-MPASLRAWPQEEYTYDNEDVVFVDNNYSDEYEFGNENEYNMQVDQEMDEFFTTADVE 1104
                ||| .|..|.|                                   |:.|.|:|  ||.: 
Mouse   950 QQLLLSLTFPRLLEA-----------------------------------VEMEEDDF--TASL- 976

  Fly  1105 YTTPPPRQHKPHVGPRFSPDPHNARRCDLRTDLYMLQPERLNQGGQNNPLKGKLTNCHVSGCERP 1169
                                  :.:.|......|..:.:..:..|        |.:|  ..|.|.
Mouse   977 ----------------------SKQSCITEQTQYFFKNDTKSFSG--------LLDC--GNCSRI 1009

  Fly  1170 FSVQKIPHSNLILLVVDT--LCPCGSKQLDIEPLEEAGVIGACSTRRQGQEQESRRRPKKCINYH 1232
            |.|:|:.::||:.::|::  .|||.::.| ::..:.:.....|...:|   ...|:.|..|.:.:
Mouse  1010 FHVEKLMNTNLVFIMVESKGTCPCDTRLL-MQAEQTSDGPDPCDMVKQ---PRYRKGPDVCFDNN 1070

  Fly  1233 PEEIEIQQCGRGSTL 1247
            ..| :...||..|.|
Mouse  1071 VLE-DYTDCGGVSGL 1084

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4587NP_001188817.2 VWA_N 108..230 CDD:285584 30/134 (22%)
vWA_VGCC_like 245..428 CDD:238740 63/182 (35%)
Cache_1 456..544 CDD:280839 35/92 (38%)
VGCC_alpha2 590..>647 CDD:285647 17/62 (27%)
Cacna2d1XP_011248046.1 VWA_N 104..223 CDD:369855 30/134 (22%)
vWA_VGCC_like 239..417 CDD:238740 63/182 (35%)
dCache_1 <437..622 CDD:376917 59/207 (29%)
VGCC_alpha2 651..1079 CDD:369894 131/613 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000496
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10166
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X365
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
44.010

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