Protein Alignment stol and Cacna2d1

DIOPT Version :10

• Sequence 1: NP_001188817.2
• Gene: stol / 34921
• FlyBaseID: FBgn0028863
• Length: 1271
• Species: Drosophila melanogaster
• Sequence 2: XP_011248046.1
• Gene: Cacna2d1 / 12293
• MGIID: 88295
• Length: 1110
• Species: Mus musculus
• Alignment Length: 1315
• Identity: 321/1315 - (24%)
• Similarity: 551/1315 - (41%)
• Gaps: 310/1315 - (23%)

  Fly     8 CFVAIVLGVLIFKMHIFVAFADQDEDIPHNEVRNWALKFGVDLWEFGRQ---FTKMNEIKSRFKD 69
            |.:|:.|  .:|:..:....:::....|.. :::|..|...||....:.   .|::.:|..:::
Mouse     5 CLLALTL--TLFQSGLIGPSSEEPFPSPVT-IKSWVDKMQEDLVTLAKTASGVTQLADIYEKYQ- 65

  Fly    70 NDIEVKRKDGIILLRELAA-EVKNFMDFKRNAVMRLMDSAEQAALSELEGQGQAESPMGGQQHYD 133
             |:.....:....|.|:|| :::..:..:..|::||...||           :.::....::.:.
Mouse    66 -DLYTVEPNNARQLVEIAARDIEKLLSNRSKALVRLAMEAE-----------KVQAAHQWREDFA 118

  Fly   134 ARRINEYNADGKL-------ADGARHM------DIRFMRRFERLPVNLSLSSILVPHGVDLDEPD 185
            :..:..|||...|       ..|::.:      |..|.|:     ::...:::.:|..:......
Mouse   119 SNEVVYYNAKDDLDPERNESEPGSQRIKPVFIEDANFGRQ-----ISYQHAAVHIPTDIYEGSTI 178

  Fly   186 VKSALQWSGHLDPLFQNNLEQDPALSWQYFGSSTGFLRRFPGTAWPPEGSKGSKL-IHDFRTHNW 249
            |.:.|.|:..||.:|:.|.::||.|.||.|||:||..|.:|.:.|.......:|: ::|.|...|
Mouse   179 VLNELNWTSALDEVFKRNRDEDPTLLWQVFGSATGLARYYPASPWVDNSRTPNKIDLYDVRRRPW 243

  Fly   250 FVQAASSPKDIMILLDASSSMTEKSFDLGMATAFNILDTLGEDDFVNLITFSEVVKTPVPCFKDR 314
            ::|.|:||||::||:|.|.|::..:..|...:...:|:||.:|||||:.:|:...: .|.||: .
Mouse   244 YIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQ-DVSCFQ-H 306

  Fly   315 MVRATPDNIQEIKSAVKAIKLQDTANFTAGLEYAFSLLHKYNQSGAGSQCNQAIMLITESTSESH 379
            :|:|...|.:.:|.||..|..:...::..|..:||..|..||.|.|  .||:.|||.|:...|..
Mouse   307 LVQANVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQLLNYNVSRA--NCNKIIMLFTDGGEERA 369

  Fly   380 KDVIKQYNWPHMPVRIFTYLIGSDSGSRSNLHDMACSNKGFFVQINDYDEARRKVIDYALVMARP 444
            :::..:|| ....||:||:.:|..:..|..:..|||.|||::.:|......|....:|..|:.||
Mouse   370 QEIFAKYN-KDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIRINTQEYLDVLGRP 433

  Fly   445 MIMY-QADHPVHWSPVFVAGKSGGLGRDSEYQRRLVTTVSTPVFDRRNHSVRVANL-----LGVV 503
            |::. .....|.|:.|::.....|          ||.|.:.|||:....|....||     |||:
Mouse   434 MVLAGDKAKQVQWTNVYLDALELG----------LVITGTLPVFNVTGQSENKTNLKNQLILGVM 488

  Fly   504 GTDVPIEEIRKVIPQHKLGPNGYSFIVDNNGRVLYHPDLRPLGDANQYIDQLKPKYASVDITELE 568
            |.||.:|:|:::.|:..|.||||.|.:|.||.||.||:|:|           ||  ..|.|..:.
Mouse   489 GVDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQP-----------KP--IGVGIPTIN 540

  Fly   569 L----PETEFGNNNEPI-------EINKNLLNEMRGDMIKPKEGETEFTVMNHYDDSKRVSTRTH 622
            |    |..:...:.||:       |:...:..|:|..||..:.||..|..:....|.:.:.....
Mouse   541 LRKRRPNVQNPKSQEPVTLDFLDAELENEIKVEIRNKMIDGESGEKTFRTLVKSQDERYIDKGNR 605

  Fly   623 RYFYGPIEDTPFTLAIVLPE------KYGSHEFVSQQEIRHSRNNVTEYFKGDNWRVHPDWVYCE 681
            .|.:.|:..|.::||:|||.      |....|.::|...:..:...:|..|.||:
Mouse   606 TYTWTPVNGTDYSLALVLPTYSFYYIKAKLEETITQARSKKGKMKDSETLKPDNF---------- 660

  Fly   682 YNSVSDLEKERESSG-------EYSSRDQEPSFGSPEEQVLHFLSRAGRPGWKWMSVRPKSPQPH 739
                       |.||       ||.: |.:|| .:..|.:|:|.....|          |:|
Mouse   661 -----------EESGYTFIAPREYCN-DLKPS-DNNTEFLLNFNEFIDR----------KTP--- 699

  Fly   740 HNMHSGSNGGNAPGSSHFGSQHQSSQGSRKAEPYFCDRALLQSLVRDAMVTDGLDRNTTGSSSGK 804
                      |.|.                     |:..|:..::.||..|:.|.:|....
Mouse   700 ----------NNPS---------------------CNTDLINRILLDAGFTNELVQNYWSK---- 729

  Fly   805 EDKHPIATLMAILKRQGYQKFV--VATSFVATRSGLLRWIDHVKRPEDTPEPHFSEDNVRAMDTS 867
                              ||.:  |...||.|..|:.|     ..|::..|..  ::|....:.|
Mouse   730 ------------------QKNIKGVKARFVVTDGGITR-----VYPKEAGENW--QENPETYEDS 769

  Fly   868 WYKRAIDQHSVEPDSFVYSVPF--GSGYAIKSNATLVTASHAIFVEHRGHKAAAGVVGLQFQHDS 930
            :|||::|.     |::|::.|:  .||.....:..:|:.:..::::.:..|.|  |||::...:|
Mouse   770 FYKRSLDN-----DNYVFTAPYFNKSGPGAYESGIMVSKAVELYIQGKLLKPA--VVGIKIDVNS 827

  Fly   931 LAKHF--INITSACTG-MTGCKRTCASDNLDCYVLDNSGFVIISEEMEHT---GKFFGQIDGTIM 989
            ..::|  .:|...|.| :..|||.  ||.:||.:||:.||::::...::|   |:|||:||.::|
Mouse   828 WIENFTKTSIRDPCAGPVCDCKRN--SDVMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPSMM 890

  Fly   990 DSLVQDRIYKRVTVNDYQGVCSDADNPYTAAG-------GILKPNRLGSWFFNHLLALSAAW--- 1044
            ..||...:|......|||.||.....|...||       .|....::|.|      |.:|||
Mouse   891 RHLVNISLYAFNKSYDYQSVCDPGAAPKQGAGHRSAYVPSIADILQIGWW------ATAAAWSIL 949

  Fly  1045 ----LSL-MPASLRAWPQEEYTYDNEDVVFVDNNYSDEYEFGNENEYNMQVDQEMDEFFTTADVE 1104
                ||| .|..|.|                                   |:.|.|:|  ||.:
Mouse   950 QQLLLSLTFPRLLEA-----------------------------------VEMEEDDF--TASL- 976

  Fly  1105 YTTPPPRQHKPHVGPRFSPDPHNARRCDLRTDLYMLQPERLNQGGQNNPLKGKLTNCHVSGCERP 1169
                                  :.:.|......|..:.:..:..|        |.:|  ..|.|.
Mouse   977 ----------------------SKQSCITEQTQYFFKNDTKSFSG--------LLDC--GNCSRI 1009

  Fly  1170 FSVQKIPHSNLILLVVDT--LCPCGSKQLDIEPLEEAGVIGACSTRRQGQEQESRRRPKKCINYH 1232
            |.|:|:.::||:.::|::  .|||.::.| ::..:.:.....|...:|   ...|:.|..|.:.:
Mouse  1010 FHVEKLMNTNLVFIMVESKGTCPCDTRLL-MQAEQTSDGPDPCDMVKQ---PRYRKGPDVCFDNN 1070

  Fly  1233 PEEIEIQQCGRGSTL 1247
            ..| :...||..|.|
Mouse  1071 VLE-DYTDCGGVSGL 1084

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
stol	NP_001188817.2	VWA_N	130..230	CDD:462464	28/112 (25%)
		vWA_VGCC_like	245..428	CDD:238740	63/182 (35%)
		PDC2_MCP_like	511..643	CDD:350337	42/148 (28%)
		VGCC_alpha2	810..>1048	CDD:462488	72/262 (27%)
Cacna2d1	XP_011248046.1	VWA_N	104..223	CDD:462464	30/134 (22%)
		vWA_VGCC_like	239..417	CDD:238740	63/182 (35%)
		dCache_1	<435..>529	CDD:460673	36/103 (35%)
		VGCC_alpha2	651..1079	CDD:462488	131/613 (21%)