DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4587 and cacna2d3

DIOPT Version :9

Sequence 1:	NP_001188817.2	Gene:	CG4587 / 34921	FlyBaseID:	FBgn0028863	Length:	1271	Species:	Drosophila melanogaster
Sequence 2:	XP_031757121.1	Gene:	cacna2d3 / 101732520	XenbaseID:	XB-GENE-13579722	Length:	1094	Species:	Xenopus tropicalis

Alignment Length:	1282	Identity:	371/1282 - (28%)
Similarity:	600/1282 - (46%)	Gaps:	262/1282 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 ADQDEDIPHNEVRNWALKFGVDLWEF-----GRQ------FTKMNEIKSRFKDNDIEVKRKDGII 81
            |..::.||.:.|:.||..||.::...     |.|      |||..|.     :.|:.::..||:.
Frog    30 AGSEQHIPLSMVKLWASAFGGEIKSIAAKYSGSQLLQKSVFTKYKEF-----EKDVTIEEIDGLQ 89

  Fly    82 LLRELAAEVKNFMDFKRNAVMRLMDSAEQAAL-----SELEGQGQAESPMGGQQHYDARRINEYN 141
            |:::||.:::.....|..||.||:::||.|.|     ::|:           .::::|..|||.:
Frog    90 LVKKLAKDMEEMFHKKSEAVRRLVEAAEDAHLKHAFDADLQ-----------YEYFNAVLINERD 143

  Fly   142 ADGKLADGARHMDIRFMRRFERLPVNLSLSSILVPHGVDLDEPDVKSALQWSGHLDPLFQNNLEQ 206
            .||...:..:...:.....|..||||:|||.:.||..|...:|::.:.:.||..|:.:|.:|.::
Frog   144 EDGNFLELGKEFLLLPNDHFNNLPVNVSLSDVQVPTNVYNKDPEIVNGIYWSEALNKVFVDNFDR 208

  Fly   207 DPALSWQYFGSSTGFLRRFPGTAWPPEGSKGSKLIHDFRTHNWFVQAASSPKDIMILLDASSSMT 271
            ||:|.||||||:.||.|::||..|.|:  :...:..|.|...|::|||:||||::||:|.|.||.
Frog   209 DPSLIWQYFGSAKGFFRQYPGIKWEPD--ENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMK 271

  Fly   272 EKSFDLGMATAFNILDTLGEDDFVNLITFSEVVKTPVPCFKDRMVRATPDNIQEIKSAVKAIKLQ 336
            .....:...|..:||||||:|||.|:|.::|.::...||....:|:|..:|.:..:..:..:..:
Frog   272 GLRLTIAKQTVSSILDTLGDDDFFNIIAYNEEIQYVEPCLNGTLVQADRNNKEHFREHLDKLYAK 336

  Fly   337 DTANFTAGLEYAFSLLHKYNQSGAGSQCNQAIMLITESTSESHKDVIKQYNWPHMPVRIFTYLIG 401
            ........|..||.||.::|.||.||.|:||||||.:...:::.::..:||||...||:||||||
Frog   337 GIGMLDIALNEAFDLLSEFNHSGEGSVCSQAIMLIADGAVDTYDNIFAKYNWPDRKVRMFTYLIG 401

  Fly   402 SDSGSRSNLHDMACSNKGFFVQINDYDEARRKVIDYALVMARPMIMYQADHPVHWSPVFVAGKSG 466
            .::....|:..|||:|||||.||:...:.:..|:.|..|::||.::.| :|.|.|:..:|
Frog   402 REAAFADNMKWMACANKGFFTQISTLADVQENVMAYLHVLSRPKVIDQ-EHDVVWTEAYV----- 460

  Fly   467 GLGRDSEYQRR----------LVTTVSTPVFDRRNHSVRVANLLGVVGTDVPIEEIRKVIPQHKL 521
                ||...:.          |:|||:.|||.|:|.:.....||||||||||::|:.|.||::||
Frog   461 ----DSTLPQAQKLADDQGLVLMTTVAMPVFSRQNETRSKGVLLGVVGTDVPVKELMKAIPKYKL 521

  Fly   522 GPNGYSFIVDNNGRVLYHPDLRPLGDANQYIDQLKPKYASVDITELELPETEFGNNNEPIEINKN 586
            |.:||:|.:.|||.:|.||:||||.:..:  .:.||.|:|||::|:|..:.:
Frog   522 GIHGYAFAITNNGYILTHPELRPLYEEGK--KRRKPNYSSVDLSEVEWEDRD------------- 571

  Fly   587 LLNEMRGDMIKPKEGETEFTVMNHYDDSKRVSTRTHRYFYGPIEDTPFTLAIVLPEKYGSHEFVS 651
              :.:|..|:..|..:....|....|..|||...|:.|:|..|:.|||:|.:||...:|.:.|
Frog   572 --DVLRNAMVNRKTEKFSMEVKKTVDKGKRVLVMTNDYYYTDIKGTPFSLGVVLSRGHGKYFF-- 632

  Fly   652 QQEIRHSRNNVTEYFKGDNWRVHPD------WVYCEYNSVSDLEKERESSGEYSSRDQEPSFGSP 710
                   |.||| ..:|.:...|||      |.||.    :||..|.....:.
Frog   633 -------RGNVT-IEEGLHDLEHPDVSLADEWSYCN----TDLHPEHRHLTQL------------ 673

  Fly   711 EEQVLHFLSRAGRPGWKWMSVRPKSPQPHHNMHSGSNGGNAPGSSHFGSQHQSSQGSRKAEPYF- 774
             |.:..:|:  |:                                               :|..
Frog   674 -EAIKIYLT--GK-----------------------------------------------DPLLQ 688

  Fly   775 CDRALLQSLVRDAMVTDGLDRNTTGSSSGKEDKHPIATLMAILKRQGYQKFVVATSFVATRSGLL 839
            ||:.|:|.::.||:|:..|:...|.              :|:.|.:...| .|..:|:.||:||.
Frog   689 CDKELIQEVLFDAVVSAPLEAYWTS--------------LALNKSENSDK-GVEVAFLGTRTGLS 738

  Fly   840 RWIDHVKRPEDTPEPHF--SEDNVRAMDTS----WYKRAIDQHSVEPDSFVYSVPFGSGYAIKSN 898
            | |:.....|......|  |||.....:..    ||:||.:|   .|.|||||:||.:|...|||
Frog   739 R-INLFVGAEQLTNQDFLTSEDRESIFNADHFPLWYRRAAEQ---IPGSFVYSIPFSTGSENKSN 799

  Fly   899 ATLVTASHAIFVEHRGHKAAAGVVGLQFQHDSLAKHFINITSACTGMTG-CKRTCASDNLDCYVL 962
              :||||.||.:...........||:|.:.:...:.|...:..|..:.| |..:|..:.::||::
Frog   800 --VVTASTAIQLLDDRKSPVVAAVGIQMKLEFFQRKFWIASRQCASLDGKCPISCDDEEINCYLI 862

  Fly   963 DNSGFVIISEEMEHTGKFFGQIDGTIMDSLVQDRIYKRVTVNDYQGVCSDADNPYTAAGGILKPN 1027
            ||:||:::||:...||.|||:::|.:|:.|:....:||:|:.|||.||........:|..:|.|.
Frog   863 DNNGFILVSEDYGQTGNFFGEVEGAVMNKLLNMGSFKRITLYDYQAVCRTTKESSDSAHSLLDPY 927

  Fly  1028 RLGSWFFNHLLALSAAWLSLMPASLRAWPQEEYTYDNEDVVF-VDNNYSDEYEFGNENEYNMQVD 1091
            |        .:..:..|:.                 .|.::| |:.|..:.:..|:..:     .
Frog   928 R--------AIFTAIKWMM-----------------TELILFLVEFNLCNWWNSGHSVK-----A 962

  Fly  1092 QEMDEFFTTADVEYTTPPPRQHKPHVGPRFSPDPHNARRCDLRTDLYMLQPERLNQGGQNNPLKG 1156
            |.:.:.....|.||..        .|..|...:......||
Frog   963 QRLKQVLEPCDTEYPA--------FVSERTIKETTGTVACD------------------------ 995

  Fly  1157 KLTNCHVSGCERPFSVQKIPHSNLILLVVDTLCPCGSKQLDIEPLEEAGV---IGACSTRRQGQE 1218
                    .|.:.|.:|:||.|||.::|||.:|.|.|    :.|:..|.:   ........:.:.
Frog   996 --------DCFKSFVIQQIPSSNLFMVVVDNVCSCSS----VTPITMAPIEIRYNESLKCERLKS 1048

  Fly  1219 QESRRRPKKCINYHPEEIEIQQCGRGSTLLHMSGSVIVAHLLMVTVT 1265
            |:.||||:.|..:|||| ..::|| |:..::...:|::..|:|:.|:
Frog  1049 QKIRRRPEACHGFHPEE-NARECG-GAFSINPRATVVLLGLVMIYVS 1093

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4587	NP_001188817.2	VWA_N	108..230	CDD:285584	42/126 (33%)
		vWA_VGCC_like	245..428	CDD:238740	73/182 (40%)
		Cache_1	456..544	CDD:280839	40/97 (41%)
		VGCC_alpha2	590..>647	CDD:285647	19/56 (34%)
cacna2d3	XP_031757121.1	VWA_N	116..232	CDD:400621	42/126 (33%)
		vWA_VGCC_like	245..428	CDD:238740	73/182 (40%)
		HK_sensor	<449..509	CDD:365792	25/69 (36%)
		PDC2_MCP_like	511..625	CDD:350337	46/130 (35%)
		VGCC_alpha2	658..1071	CDD:400667	133/574 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	129	1.000	Domainoid score	I5180
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	571	1.000	Inparanoid score	I1042
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110668at33208
OrthoFinder	1	1.000	-	-		FOG0000496
OrthoInspector	1	1.000	-	-		mtm9510
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X365
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.060