DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4587 and cacna2d3a

DIOPT Version :9

Sequence 1:	NP_001188817.2	Gene:	CG4587 / 34921	FlyBaseID:	FBgn0028863	Length:	1271	Species:	Drosophila melanogaster
Sequence 2:	XP_009302617.1	Gene:	cacna2d3a / 100535196	ZFINID:	ZDB-GENE-060328-4	Length:	1080	Species:	Danio rerio

Alignment Length:	1262	Identity:	370/1262 - (29%)
Similarity:	587/1262 - (46%)	Gaps:	241/1262 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 EDIPHNEVRNWALKFGVDLWEFGRQFTKMNEIKSRFK--DNDIEVKRKDGIILLRELAAEVKNFM 94
            :.||.:.|:.||..||.::.....:::....::.::|  :..:.|:..|||.|:::|||:::...
Zfish    26 QGIPLSVVKLWASAFGGEIKSIAAKYSGSQLLQKKYKEFERSVRVEEIDGIKLVKKLAAKMEQRF 90

  Fly    95 DFKRNAVMRLMDSAEQAALSELEGQGQAESPMGGQQHYDARRINEYNADGKLADGARHMDIRFMR 159
            ..|..|:.||:::||:|.|:      ..|.|....::::|..|||.:.:|:..:......::...
Zfish    91 HKKAEAIKRLVEAAEEAHLN------HEEDPDLQYEYFNAVLINELDEEGRSVELGGEFILQPNE 149

  Fly   160 RFERLPVNLSLSSILVPHGVDLDEPDVKSALQWSGHLDPLFQNNLEQDPALSWQYFGSSTGFLRR 224
            .|..|.||||||.:.||..:...:.|:.:.:.||..|:.:|.:|.::||:|.||||||:.||.|:
Zfish   150 HFNNLSVNLSLSVVQVPTNMYNKDSDIVNGVYWSEALNTVFVDNFKRDPSLLWQYFGSAQGFFRQ 214

  Fly   225 FPGTAWPPEGSKGSKLIHDFRTHNWFVQAASSPKDIMILLDASSSMTEKSFDLGMATAFNILDTL 289
            :||..|.|:  :...|..|.|...|::|||:||||::||:|.|.||......:...|..:|||||
Zfish   215 YPGMKWTPD--EHGVLEFDCRNRKWYIQAATSPKDVVILVDVSGSMKGLRLTIARQTVSSILDTL 277

  Fly   290 GEDDFVNLITFSEVVKTPVPCFKDRMVRATPDNIQEIKSAVKAIKLQDTANFTAGLEYAFSLLHK 354
            |:|||.|:|.::|.:....||....:|:|...|....:..:..:..:........|..||.||..
Zfish   278 GDDDFFNVIAYNEDLHYVEPCLNGTLVQADITNKDHFRQRLDKLLAKGIGMLDVALTEAFELLSN 342

  Fly   355 YNQSGAGSQCNQAIMLITESTSESHKDVIKQYNWPHMPVRIFTYLIGSDSGSRSNLHDMACSNKG 419
            :||:|.||:|:|||||:|:...|::..|...||||...||:|.||||.:|....||..|||:|||
Zfish   343 FNQTGRGSECSQAIMLVTDGAVETYDAVFAVYNWPDRKVRVFPYLIGRESAFADNLKWMACANKG 407

  Fly   420 FFVQINDYDEARRKVIDYALVMARPMIMYQADHPVHWSPVFVAGKSGGLGRDSEYQRR-LVTTVS 483
            :|.||:...:.:..|:.|..|::||.:: ..:|.:.|:..::........:..:.|.. |:|||:
Zfish   408 YFTQISTLADVQENVMKYLHVLSRPKVI-DREHDMVWTEAYIDNTRSQAQKLEDAQGPVLMTTVA 471

  Fly   484 TPVFDRRNHSVRVANLLGVVGTDVPIEEIRKVIPQHKLGPNGYSFIVDNNGRVLYHPDLRPLGDA 548
            .|||..:|.:.....||||||||||:.||.|.||::|||.:||:|.:.|||.:|.||||:||.:.
Zfish   472 MPVFSTKNETRNKGILLGVVGTDVPVSEILKAIPKYKLGIHGYAFAITNNGYILTHPDLQPLYEE 536

  Fly   549 NQYIDQLKPKYASVDITELELPETEFGNNNEPIEINKNLLNEMRGDMIKPKEGETEFTVMNHYDD 613
            .:  .:.|..|:|.|::|:|..:.|               :|:|..|:..:.|.....|....|.
Zfish   537 GK--KRRKSSYSSADLSEVEWEDKE---------------DELRNAMVNRQTGSFSMKVKKTVDK 584

  Fly   614 SKRVSTRTHRYFYGPIEDTPFTLAIVLPEKYGSHEF---VSQQEIRHSRNNVTEYFKGDNWRVHP 675
            .|||....:.|:|..|:.|||:|.:.|...:|.:.|   :|.:|..|...             ||
Zfish   585 GKRVLVLHNDYYYTDIKGTPFSLGVALSGGHGKYVFRGNISVEEGLHDLE-------------HP 636

  Fly   676 D------WVYCEYNSVSDLEKERESSGEYSSRDQEPSFGSPEEQVLHFLSRAGRPGWKWMSVRPK 734
            |      |.||......|                .|.....|...|:|
Zfish   637 DVALADEWTYCNTEEHPD----------------HPVLSQIEAIKLYF----------------- 668

  Fly   735 SPQPHHNMHSGSNGGNAPGSSHFGSQHQSSQGSRKAEPYFCDRALLQSLVRDAMVTDGLDRNTTG 799
                                  .|.:|..           ||:.|:|.::.||:||..|:...|.
Zfish   669 ----------------------NGEEHLK-----------CDQELVQEVLFDAVVTAPLEAYWTS 700

  Fly   800 SSSGKEDKHPIATLMAILKRQGYQKFVVATSFVATRSGLLRWIDHVKRPE----------DTPEP 854
                          :|:.|.:...| .|..||:|||:||.| |:....|:          :..|.
Zfish   701 --------------LALNKSENSDK-GVEISFLATRTGLSR-INLFVTPDQLSNQGLLTGEDKEV 749

  Fly   855 HFSEDNVRAMDTSWYKRAIDQHSVEPDSFVYSVPFGSGYAIKSNATLVTASHAIFVEHRGHKAAA 919
            .||.|:.    ..||:||.:|   .|.:||||:|:.   |...|.::|.||.||.:........|
Zfish   750 QFSADHF----PLWYRRAAEQ---VPGTFVYSLPYD---AASDNKSVVLASSAIHLLDERESPIA 804

  Fly   920 GVVGLQFQHDSLAKHFINITSACTGMTG-CKRTCASDNLDCYVLDNSGFVIISEEMEHTGKFFGQ 983
            ..||:|.:.:...:.|...:..|..:.| |..:|.:|::.||::||:||:|::|:...||.|||:
Zfish   805 AAVGIQMKLEFFQRKFWTASRQCAALDGKCSISCDNDDISCYLIDNNGFIIVAEDQSLTGVFFGE 869

  Fly   984 IDGTIMDSLVQDRIYKRVTVNDYQGVC----SDADNPYTAAGGILKPNRLGSWFFNHLLALSAA- 1043
            .:|.:|..||....:|||.:.||:.:|    ..:|..:|    :|.|      :|    ||.||
Zfish   870 PEGAVMGKLVSMGSFKRVNLYDYRAICRVYAQTSDTAHT----LLHP------YF----ALFAAI 920

  Fly  1044 -WLSLMPASLRAWPQEEYTYDNEDVVFVDNNYSDEYEFGNENEYNMQVDQEMDEFFTTADVEYTT 1107
             ||.                 .|.|:|:       .||   |.|:          :..:|:..|.
Zfish   921 RWLL-----------------TEFVIFL-------VEF---NLYS----------WWHSDLTITA 948

  Fly  1108 PPPRQHKPHVGPRFSPDPHNARRCDLRTDLYMLQPERLNQGGQNNPLKGKLTNCHVSGCERPFSV 1172
                    |.|.|....|     ||  |:......||        .:|..:.|.....|.:.|.:
Zfish   949 --------HRGGRTLLVP-----CD--TEYPAFVSER--------TIKETVGNIDCESCVKSFVI 990

  Fly  1173 QKIPHSNLILLVVDTLCPCGS-KQLDIEPLEEAGVIGACSTRRQGQE-QESRRRPKKCINYHPEE 1235
            |:||.|||.::|:|..|.|.. ..:.:||:|   ::...|.:.:..: |:.||||..|..:|.||
Zfish   991 QQIPSSNLFMVVIDNTCDCSDFGPVTMEPVE---IMYNESLKCERLKFQKDRRRPDTCHPFHHEE 1052

  Fly  1236 IEIQQCGRGSTLLHMSGSVIVAHLLMV 1262
             ...:|| ||..|..|...::..::.:
Zfish  1053 -NSMECG-GSVSLSPSSPALLVLIISI 1077

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4587	NP_001188817.2	VWA_N	108..230	CDD:285584	41/121 (34%)
		vWA_VGCC_like	245..428	CDD:238740	75/182 (41%)
		Cache_1	456..544	CDD:280839	39/88 (44%)
		VGCC_alpha2	590..>647	CDD:285647	18/56 (32%)
cacna2d3a	XP_009302617.1	SPEC	<52..>103	CDD:295325	13/50 (26%)
		VWA_N	104..220	CDD:285584	41/121 (34%)
		vWA_VGCC_like	233..416	CDD:238740	75/182 (41%)
		Cache_1	443..539	CDD:280839	41/97 (42%)
		VGCC_alpha2	552..625	CDD:285647	22/87 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I12183
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	572	1.000	Inparanoid score	I1017
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110668at33208
OrthoFinder	1	1.000	-	-		FOG0000496
OrthoInspector	1	1.000	-	-		mtm6553
orthoMCL	1	0.900	-	-		OOG6_103783
Panther	1	1.100	-	-	O	PTHR10166
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X365
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.970