Protein Alignment CG4587 and cacna2d4

DIOPT Version :9

• Sequence 1: NP_001188817.2
• Gene: CG4587 / 34921
• FlyBaseID: FBgn0028863
• Length: 1271
• Species: Drosophila melanogaster
• Sequence 2: XP_031754464.1
• Gene: cacna2d4 / 100488361
• XenbaseID: XB-GENE-991123
• Length: 1121
• Species: Xenopus tropicalis
• Alignment Length: 1302
• Identity: 362/1302 - (27%)
• Similarity: 591/1302 - (45%)
• Gaps: 274/1302 - (21%)

  Fly    34 IPHNEVRNWALKFGVDLWEFGRQFTKMNEIKSRFKDND--IEVKRKDGIILLRELAAEVKNFMDF 96
            |..:.|:.||..||.:::....:::....::.::||.:  :.::..||:.|:::.:.|::|.:..
 Frog    21 ISTDTVKIWADAFGGEVYSLVTRYSGSLLLQKKYKDVEPTLSIEEVDGLELVKKFSEEMENMLRR 85

  Fly    97 KRNAVMRLMDSAEQAAL-----SELEGQGQAESPMGGQQHYDARRINEYNADGKLADGARHMDIR 156
            |..||.:|:::||.|.|     :.||           .::|::.||||.:.:....:......:.
 Frog    86 KVEAVEKLVEAAEDADLHHEFNTSLE-----------FEYYNSVRINEKDENDNYVELGSEFILE 139

  Fly   157 FMRRFERLPVNLSLSSILVPHGVDLDEPDVKSALQWSGHLDPLFQNNLEQDPALSWQYFGSSTGF 221
            ....|..|.||.|||:|.:|..|...:|.:.:.:..|..|:|:|.:|.::||.|:|||||||:||
 Frog   140 TNEHFNNLMVNTSLSNIQLPTNVYNKDPSILNGVYMSEALNPIFVDNFQRDPTLTWQYFGSSSGF 204

  Fly   222 LRRFPGTAWPPEGSKGSKLIHDFRTHNWFVQAASSPKDIMILLDASSSMTEKSFDLGMATAFNIL 286
            .|.:||..|.|:  :...:..|.|...|::|||:|||||:|::|.|.||......:...|...:|
 Frog   205 FRLYPGIKWVPD--ENGVISFDCRNRGWYIQAATSPKDIVIVVDISGSMKGLRMTIAKHTISTLL 267

  Fly   287 DTLGEDDFVNLITFSEVVKTPVPCFKDRMVRATPDNIQEIKSAVKAIKLQDTANFTAGLEYAFSL 351
            |||||:||||:|.:::.|....||||..:|:|..||.:..|..|..:..:........|..||.:
 Frog   268 DTLGENDFVNIIAYNDYVHYIEPCFKGILVQADRDNREHFKQLVDELHAKGVGTVNKALIEAFKI 332

  Fly   352 LHKYNQSGAGSQCNQAIMLITESTSESHKDVIKQYNWPHMPVRIFTYLIGSDSGSRSNLHDMACS 416
            |.::.::|.|..|||||||||:...|.::.|.::||:|...||:||||||.:....||:..:||:
 Frog   333 LKEFREAGQGGLCNQAIMLITDGAVEEYEPVFEKYNFPDRKVRLFTYLIGREVTFSSNVKWIACN 397

  Fly   417 NKGFFVQINDYDEARRKVIDYALVMARPMIMYQADHPVHWSPVFVAG---KSGGLGRDSEYQRRL 478
            |||::.||:...:.:..|::|..|::|||:: ..||.:.|:..::..   :|..|.........|
 Frog   398 NKGYYTQISTLADVQENVMEYLHVLSRPMVI-NHDHDIIWTEAYMDSALPQSEELFASQAQSLLL 461

  Fly   479 VTTVSTPVFDRRNHSVRVANLLGVVGTDVPIEEIRKVIPQHKLGPNGYSFIVDNNGRVLYHPDLR 543
            :|||:.|||.::|.:.....||||||:|||:.|:.|:.|::|||.:||:|:..|||.:|.|||||
 Frog   462 MTTVAMPVFSKKNETRSEGILLGVVGSDVPLRELLKLAPRYKLGVHGYAFLNTNNGYILSHPDLR 526

  Fly   544 PLGDANQYIDQLKPKYASVDITELELPETEFGNNNEPIEINKNLLNEMRGDMIKPKEGETEFTVM 608
            ||....:.: :.||.|.|||::|:|..:.:        ||       :|..||..:.|.....|.
 Frog   527 PLYKEGKKL-RPKPNYNSVDLSEVEWEDKD--------EI-------LRTAMINGETGSLTMDVK 575

  Fly   609 NHYDDSKRVSTRTHRYFYGPIEDTPFTLAIVLPEKYGSHEFVSQQEIRHSRNNVTEYFKGDNWRV 673
            ...|..|||...|..|||..|:||||:|.:||...:|.:..:.........:::          :
 Frog   576 VPVDKGKRVLFLTSDYFYTHIDDTPFSLGVVLSRGHGEYILIGNTSAEEGLHDL----------L 630

  Fly   674 HPD------WVYCEYNSVSDLEKERESSGEYSSRDQEPSFGSPEEQVLHFLSRAGRPGWKWMSVR 732
            |||      |:||    |:|::.:.....:.             :.|..||:
 Frog   631 HPDLTVANEWIYC----VTDIDPDHRKLSQL-------------QAVKKFLT------------- 665

  Fly   733 PKSPQPHHNMHSGSNGGNAPGSSHFGSQHQSSQGSRKAEPYFCDRALLQSLVRDAMVTDGLDRNT 797
                            |..|...                   ||..|||.::.||:||..|:...
 Frog   666 ----------------GEDPDLE-------------------CDEELLQEVLFDAVVTAPLEAYW 695

  Fly   798 TGSSSGKEDKHPIATLMAILKRQGYQKFVVATSFVATRSGLLR---WIDHVKRPEDTPEPHFSED 859
            |          .:|..|: .|.:|     :..:|:.||:||:|   ::.:.|........:..::
 Frog   696 T----------QLALNMS-SKDEG-----IEVAFLGTRAGLMRKNQFVGNEKLTNKKFLQYEDKE 744

  Fly   860 NVRAMD--TSWYKRAIDQHSVEPDSFVYSVPFGS-------------------GYAIKSNATL-- 901
            ::..||  ..||:||.:..:   .||||.:|...                   |...:||..|
 Frog   745 SIFTMDHFPLWYRRAAEHPA---GSFVYHIPTDDNPDHNPSDNDISEPPGQPLGSDEQSNKELGR 806

  Fly   902 ----VTASHAIFVEHRGHKAAAGVVGLQFQHDSLAKHF------INITSACTGMTG-CKRTCASD 955
                ||.|.||.|......|.|..:|:|.:...|...|      .|.|. |..:.| |..:|..:
 Frog   807 RLEVVTVSTAISVTVHSKTAIAAAIGVQMKLSLLESVFWKTMRQPNDTD-CRNVEGLCPLSCQDE 870

  Fly   956 NLDCYVLDNSGFVIISEEMEHTGKFFGQIDGTIMDSLVQDRIYKRVTVNDYQGVCSDADNPYTAA 1020
            .|.||::||:||::|:::.:.||.|.|:::|:::..|:...::::|.:.|||.:|....:.::.|
 Frog   871 TLQCYLVDNNGFIVIAKDQDKTGVFLGEVEGSLISQLLNMGVFRQVKLYDYQAMCKHPYHYHSGA 935

  Fly  1021 GGILKP----NRLGSWFFNHLL------ALSAAWLSLMPASLRAWPQEEYTYDNEDVVFVDNNYS 1075
            ..:|.|    .....||..:|:      :|...|.|                        ||...
 Frog   936 RNLLNPLVALMSAAQWFIGNLVLFFLEFSLCPFWAS------------------------DNTVQ 976

  Fly  1076 DEYEFGNENEYNMQVDQEMDEFFTTADVEYTTPPPRQHKPHVGPRFSPDPHNARRCDLRTDLYML 1140
            .:..|.:.:                           :||.|  ....|       ||.....::.
 Frog   977 AKSFFHHSH---------------------------KHKKH--DMLQP-------CDTEYPAFIH 1005

  Fly  1141 QPERLNQGGQNNPLKGKLTNCHVSGCERPFSVQKIPHSNLILLVVDTLCPCGS-KQLDIEPLE-- 1202
            :.......|        |.||  ..|::.|.:|::.:|||:|||.|..|.|.: ..:.:...|
 Frog  1006 EASIQEANG--------LINC--GECQKMFVLQQVMNSNLLLLVTDATCDCSTFPPVSLRAKEVK 1060

  Fly  1203 -EAGVIGACSTRRQGQEQESRRRPKKCINYHPEEIEIQQCGRGSTLLHMSGSVIVAHLLMVTVTF 1266
             .|.|  .|...|   .|:.||||:.|..:|||| ..|.||      .:||......||...:|.
 Frog  1061 YNASV--KCDRMR---SQKLRRRPQSCHAFHPEE-NAQDCG------GVSGITPTLTLLFAALTV 1113

  Fly  1267 VL 1268
            .|
 Frog  1114 SL 1115

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4587	NP_001188817.2	VWA_N	108..230	CDD:285584	42/126 (33%)
		vWA_VGCC_like	245..428	CDD:238740	75/182 (41%)
		Cache_1	456..544	CDD:280839	37/90 (41%)
		VGCC_alpha2	590..>647	CDD:285647	22/56 (39%)
cacna2d4	XP_031754464.1	VWA_N	97..213	CDD:400621	42/126 (33%)
		vWA_VGCC_like	226..409	CDD:238740	75/182 (41%)
		HK_sensor	<433..492	CDD:365792	19/58 (33%)
		PDC2_MCP_like	494..609	CDD:350337	51/130 (39%)
		VGCC_alpha2	664..1095	CDD:400667	127/574 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	129	1.000	Domainoid score	I5180
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H26544
Inparanoid	1	1.050	571	1.000	Inparanoid score	I1042
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110668at33208
OrthoFinder	1	1.000	-	-		FOG0000496
OrthoInspector	1	1.000	-	-		mtm9510
Panther	1	1.100	-	-	LDO	PTHR10166
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X365
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160