DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4587 and cacna2d4b

DIOPT Version :9

Sequence 1:	NP_001188817.2	Gene:	CG4587 / 34921	FlyBaseID:	FBgn0028863	Length:	1271	Species:	Drosophila melanogaster
Sequence 2:	XP_009296274.2	Gene:	cacna2d4b / 100150428	ZFINID:	ZDB-GENE-100422-18	Length:	1100	Species:	Danio rerio

Alignment Length:	1278	Identity:	358/1278 - (28%)
Similarity:	582/1278 - (45%)	Gaps:	238/1278 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 WSCFVAIVLGVLIFKMHIFVAFADQDEDIPHNEVRNWALKFGVDLWEFGRQFTKMNEIKSRFKDN 70
            |..|:.:..|.:..       |......||...|:.|||.....:.....:::.....:.:.||.
Zfish     9 WVTFLLLSTGWMCM-------FTHAQMKIPPETVQKWALTISEQINAIASKYSGAALFQKKLKDV 66

  Fly    71 D--IEVKRKDGIILLRELAAEVKNFMDFKRNAVMRLMDSAEQAAL-SELEGQGQAESPMGGQQHY 132
            :  |.::..||..|:.|.|.|::..:..|..:..||.|:||.|.| .|.....|.:       ::
Zfish    67 EPIIRIEDLDGSELVLEFAEEIERMLGSKMRSAKRLADTAEDADLYHEFNSSLQFD-------YF 124

  Fly   133 DARRINEYNADGKLADGARHMDIRFMRRFERLPVNLSLSSILVPHGVDLDEPDVKSALQWSGHLD 197
            :|..:|..:.:|...:......:.....|.:|.||..:|.|.||..|...:||:.:.:..|..|:
Zfish   125 NALLVNTMDEEGNFIELGGEFPLEENNHFSKLAVNTLMSDIQVPTNVYNKDPDILNGVYMSEALN 189

  Fly   198 PLFQNNLEQDPALSWQYFGSSTGFLRRFPGTAWPPEGSKGSKLIHDFRTHNWFVQAASSPKDIMI 262
            .:|.||.::||.|:||||.|.|||.|.:||..|.|:.:  ..:..|.|..||::|||:||||::|
Zfish   190 DIFINNFQKDPTLTWQYFCSQTGFFRLYPGIRWTPDAN--GVVSFDCRNRNWYIQAATSPKDLVI 252

  Fly   263 LLDASSSMTEKSFDLGMATAFNILDTLGEDDFVNLITFSEVVKTPVPCFKDRMVRATPDNIQEIK 327
            ::|.|.||......:...|...|||||||:||||:|.:::.|....||||..:|:|..||.:..|
Zfish   253 VVDVSGSMKGLKMTIAKHTINTILDTLGENDFVNVIAYTDYVSYVEPCFKGTLVQADLDNREHFK 317

  Fly   328 SAVKAIKLQDTANFTAGLEYAFSLLHKYNQSGAGSQCNQAIMLITESTSESHKDVIKQYNWPHMP 392
            ..|..:.::..|.....::.:|.:|.....:|.||.|||||||||:...|..:.|.:::|||...
Zfish   318 LLVDELHVKGEAKVKKAMKESFRILADARANGQGSLCNQAIMLITDGAMEDFQSVFEEFNWPDKK 382

  Fly   393 VRIFTYLIGSDSGSRSNLHDMACSNKGFFVQINDYDEARRKVIDYALVMARPMIMYQADHPVHWS 457
            ||:||||||.|.....|:..:||:||||:..::...:.:..|::|..|::|||:: ..||.:.|:
Zfish   383 VRVFTYLIGRDMTFSENVKWIACNNKGFYAHVSTLADVQENVMEYLHVLSRPMVI-NHDHDIIWT 446

  Fly   458 PVF---VAGKSGGLGRDSEYQRRLVTTVSTPVFDRRNHSVRVANLLGVVGTDVPIEEIRKVIPQH 519
            ..:   |...:..:.:...:....:|:|:.|||.::..::....||||||||:|:.|:.|:.|::
Zfish   447 EAYMDSVLPNTMEVFKSKAHSLLFMTSVAMPVFSKKKETLSHGILLGVVGTDIPLLEVMKLAPRY 511

  Fly   520 KLGPNGYSFIVDNNGRVLYHPDLRPLGDANQYID--QLKPK--YASVDITELELPETEFGNNNEP 580
            |||.:||:|::.|||.:|.|||||||     |.:  :||||  |.|||::|.|..:||
Zfish   512 KLGAHGYAFLITNNGYILAHPDLRPL-----YYEGKKLKPKPNYNSVDLSEAEWEDTE------- 564

  Fly   581 IEINKNLLNEMRGDMIKPKEGETEFTVMNHYDDSKRVSTRTHRYFYGPIEDTPFTLAIVLPEKYG 645
                    :.:|..|:|.:.|.....|....|..||.....:.|||..|::|||:..:||.:.:|
Zfish   565 --------DNLRTAMVKGETGTLALDVRTAVDKGKRPLFLKNDYFYTTIDETPFSFGMVLTKGHG 621

  Fly   646 SHEFVSQQEIRHSRNNVTEYFKGDNWRVHPDWVYCEYNSVSDLEKERESSGEYSSRDQEPSFGSP 710
            .:.|.....:....:::.:    .:..:..:|.|||    :|::.:.....:.
Zfish   622 QYMFFGNVSVEEGLHDLQQ----PDLTIAEEWTYCE----TDIDPQHRKLNQL------------ 666

  Fly   711 EEQVLHFLSRAGRPGWKWMSVRPKSPQPHHNMHSGSNGGNAPGSSHFGSQHQSSQGSRKAEPYFC 775
             :.|:.:|:             .|.|:..                                   |
Zfish   667 -QAVVRYLT-------------GKEPELE-----------------------------------C 682

  Fly   776 DRALLQSLVRDAMVTDGLDRNTT-------GSSSGKEDKHPIATLMAILKRQGYQKFVVATSFVA 833
            |..|||.::.||:||..|:...|       |...|.|                       ::|:.
Zfish   683 DEILLQQVLFDAVVTAPLEAYWTRLTLTPPGVDEGME-----------------------SAFLG 724

  Fly   834 TRSGLLRWIDHV---KRPEDTPEPHFSEDNVRAMD--TSWYKRAIDQHSVEPDSFVYSVPFGSGY 893
            ||||:||.|.:.   ||..........::|:..:|  ..||:.|.:.   .|..|::.||:..
Zfish   725 TRSGVLRVIRYTGIEKRLGKKFLTRVDKENLFTVDHFPIWYRLAAEN---TPGQFLFYVPYDD-- 784

  Fly   894 AIKSNATLVTASHAIFVEHRGHKAAAGVVGLQFQHDSLAKHFINIT-----SACTGMTG-CKRTC 952
             |........|..::.|..|...|.||.:|:|...|.|.:.|::|.     :.|..:.| |..:|
Zfish   785 -INKGKNTFVAVTSVTVTERKRTAIAGAIGMQASLDVLERIFMSIAKQPNDTDCNDVEGICPLSC 848

  Fly   953 ASDNLDCYVLDNSGFVIISEEMEHTGKFFGQIDGTIMDSLVQDRIYKRVTVNDYQGVCSDADNPY 1017
            .|.:|:||::|::||:::|::....|:|||:|||::|..|::..:|||||:.|||.:|....:..
Zfish   849 ESIDLNCYLVDSNGFILMSKDRGDVGRFFGEIDGSVMAQLLKSGLYKRVTLYDYQAMCKTGHHHS 913

  Fly  1018 TAAGGILKPNRLGSWFFNHLLALSAAWLSLMPASLRAWPQEEYTYDNEDVVFVDNNYSDEYEFGN 1082
            :.|..:|.|       |..||||...|.|                  ..|:|:       .||..
Zfish   914 SGARPLLSP-------FYALLALIKWWFS------------------HFVMFM-------LEFNI 946

  Fly  1083 ----ENEYNMQVDQEMDEFFTTADVEYTTPPPRQHKPHVGPRFSPDPHNARRCDLRTDLYMLQPE 1143
                .|:|  .||.:.. |.||                         |..::.:|      :||.
Zfish   947 CGLWHNDY--VVDAKAG-FHTT-------------------------HKQKKVEL------MQPC 977

  Fly  1144 RLNQGGQNNPLKGKLTNCHV--SGCERPFSVQKIPHSNLILLVVDTLCPCGSKQLDIEPLEEAGV 1206
            .....|.......:.||..:  ..|::.|.:|:||:|||::|||...|.|..:...|..:.:...
Zfish   978 NTEYPGFMYDKSIRETNSIIKCGRCQKMFVLQQIPNSNLVMLVVQADCDCSRQYAPITLMPKEVK 1042

  Fly  1207 IGACSTRRQGQEQESRRRPKKCINYHPEEIEIQQCGR--GSTL 1247
            ..|.....:.:.|:.||||:.|.:||..| ..:.||.  |.||
Zfish  1043 YNATVKCNRMKSQKIRRRPESCHSYHAHE-NAEDCGGACGITL 1084

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4587	NP_001188817.2	VWA_N	108..230	CDD:285584	39/122 (32%)
		vWA_VGCC_like	245..428	CDD:238740	75/182 (41%)
		Cache_1	456..544	CDD:280839	33/90 (37%)
		VGCC_alpha2	590..>647	CDD:285647	18/56 (32%)
cacna2d4b	XP_009296274.2	VWA_N	112..222	CDD:312040	35/116 (30%)
		vWA_VGCC_like	235..418	CDD:238740	75/182 (41%)
		dCache_1	414..>533	CDD:308398	38/119 (32%)
		VGCC_alpha2	650..1028	CDD:312092	124/537 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	109	1.000	Domainoid score	I6280
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H26544
Inparanoid	1	1.050	572	1.000	Inparanoid score	I1017
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110668at33208
OrthoFinder	1	1.000	-	-		FOG0000496
OrthoInspector	1	1.000	-	-		mtm6553
orthoMCL	1	0.900	-	-		OOG6_103783
Panther	1	1.100	-	-	LDO	PTHR10166
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X365
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.970