Protein Alignment stol and cacna2d3

DIOPT Version :10

• Sequence 1: NP_001188817.2
• Gene: stol / 34921
• FlyBaseID: FBgn0028863
• Length: 1271
• Species: Drosophila melanogaster
• Sequence 2: XP_073773099.1
• Gene: cacna2d3 / 100148645
• ZFINID: ZDB-GENE-030616-133
• Length: 1082
• Species: Danio rerio
• Alignment Length: 1252
• Identity: 368/1252 - (29%)
• Similarity: 592/1252 - (47%)
• Gaps: 225/1252 - (17%)

  Fly    33 DIPHNEVRNWALKFGVDLWEFGRQFTKMNEIKSRFK--DNDIEVKRKDGIILLRELAAEVKNFMD 95
            :||.:.|:.||..||.::.....:::....::.::|  :..:.::..||..|::.||..::....
Zfish    31 EIPLSVVKLWASAFGGEIKSIASKYSGSQLLQKKYKEYEKSVRIEEIDGAKLVKNLAQNMEEMFR 95

  Fly    96 FKRNAVMRLMDSAEQAALSELEGQGQAESPMGGQQHYDARRINEYNADGKLADGARHMDIRFMRR 160
            .|..|..||:::||:|.|.      ..|:|....::::|..|||.:.||...:......:.....
Zfish    96 KKAEATRRLVEAAEEAHLQ------HEENPDLQYEYFNAVLINEVDEDGNSVELGGEFLLEPNDH 154

  Fly   161 FERLPVNLSLSSILVPHGVDLDEPDVKSALQWSGHLDPLFQNNLEQDPALSWQYFGSSTGFLRRF 225
            |..|.||||||.:.||..:...:||:.:.:.||..|:.:|.:|..:||.|.||||||:.||.|::
Zfish   155 FNNLSVNLSLSVVQVPTNMYNKDPDIVNGVYWSEALNKVFVDNFRRDPTLIWQYFGSAKGFFRQY 219

  Fly   226 PGTAWPPEGSKGSKLIHDFRTHNWFVQAASSPKDIMILLDASSSMTEKSFDLGMATAFNILDTLG 290
            ||..|.|:  :...:..|.|...|::|||:||||::||:|.|.||......:...|..:||||||
Zfish   220 PGVKWYPD--EHGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGLRLTIARQTVASILDTLG 282

  Fly   291 EDDFVNLITFSEVVKTPVPCFKDRMVRATPDNIQEIKSAVKAIKLQDTANFTAGLEYAFSLLHKY 355
            :|||.|:|.:::.:....||....:|:|...|....|..:..:..:........|..||::|::.
Zfish   283 DDDFFNIIAYNQEIHYVEPCLNGTLVQADSTNKDHFKEHLDKLFAKGIGLLGNALSEAFTILNEI 347

  Fly   356 NQSGAGSQCNQAIMLITESTSESHKDVIKQYNWPHMPVRIFTYLIGSDSGSRSNLHDMACSNKGF 420
            ||:|.||.|:|||||||:..:|.:.||..:||||...||||.||||.:|....||..|||:|||:
Zfish   348 NQTGRGSSCSQAIMLITDGATEMYDDVFAKYNWPERKVRIFPYLIGRESAFADNLKWMACANKGY 412

  Fly   421 FVQINDYDEARRKVIDYALVMARPMIMYQADHPVHWSPVFV---AGKSGGLGRDSEYQRRLVTTV 482
            |.||:...:.:..|:.|..||:||.:: ..:|...|:..:|   ..::..||.:.  ....:|||
Zfish   413 FSQISTLADVQENVMRYLHVMSRPKVI-DHEHDTVWTEAYVDSALAQAHKLGENK--GPNPMTTV 474

  Fly   483 STPVFDRRNHSVRVANLLGVVGTDVPIEEIRKVIPQHKLGPNGYSFIVDNNGRVLYHPDLRPLGD 547
            :.|||..:|.:.....||||.|||:||:|:.||||:||||.:||:|.:.:||.:|.|||||||..
Zfish   475 AMPVFSTKNETKNQGILLGVAGTDIPIQELMKVIPKHKLGIHGYAFAITSNGYLLLHPDLRPLYQ 539

  Fly   548 ANQYIDQLKPKYASVDITELELPETEFGNNNEPIEINKNLLNEMRGDMIKPKEGETEFTVMNHYD 612
            ..|  .:.||.|:|||::|:|..:||               :.:|..|:..|.|.....|....|
Zfish   540 EGQ--KRKKPSYSSVDLSEVEWEDTE---------------DVLRTAMVNRKTGTFSMEVKRTVD 587

  Fly   613 DSKRVSTRTHRYFYGPIEDTPFTLAIVLPEKYGSHEFVSQQEIRHSRNNVTEYFKGDNWRVHPDW 677
            ..|||.|..:.|:|..|:.|||::.:.|...:|.:                 :|||:
Zfish   588 KGKRVLTMHNDYYYTDIKGTPFSVGVALSRGHGKY-----------------FFKGN-------- 627

  Fly   678 VYCEYNSVSDLEKERESSGEYSSRDQEPSFGSPEEQVLHFLSRAGRPGWKWMSVRPKSPQPHHNM 742
            |..| ..:.|||              :|.....:|             |.:.:    :.:.|.:.
Zfish   628 VSLE-AGLHDLE--------------QPDVALADE-------------WTYCT----TEEHHEHR 660

  Fly   743 HSGSNGGNAPGSSHFGSQHQSSQ---GSRKAEPYF-CDRALLQSLVRDAMVTDGLDRNTTGSSSG 803
            |.              :|.|:.:   .|||  |:| |||.|:|.::.||:||..::...||
Zfish   661 HL--------------TQVQAIKIYMTSRK--PHFKCDRELIQQVLFDAVVTAPVEAYWTG---- 705

  Fly   804 KEDKHPIATLMAILKRQGYQKFVVATSFVATRSGLLRWIDHVKRPEDTPEPHFSEDNVRAMDTS- 867
                      :|:.|.:...| .|..:|:.||:||.|....|     .||...:.|.:.|.|..
Zfish   706 ----------LALNKSENSDK-GVEIAFLGTRTGLSRTNLFV-----VPEQLTNRDFLTAEDKEG 754

  Fly   868 ---------WYKRAIDQHSVEPDSFVYSVPFGSGYAIKSNATLVTASHAIFVEHRGHKAAAGVVG 923
                     |||||.:|   .|.:||||:||.||   ..|.::|.||.||.:...........||
Zfish   755 VFNADHFPLWYKRAAEQ---VPGTFVYSIPFSSG---GENKSVVLASTAIQLLDDRKSPIVAAVG 813

  Fly   924 LQFQHDSLAKHFINITSACTGMTG-CKRTCASDNLDCYVLDNSGFVIISEEMEHTGKFFGQIDGT 987
            :|.:.:...:.|...:..|..:.| |..:|.::::.||::||:||:::||:...|..|||:::|.
Zfish   814 IQMKLEFFQRKFWTASRQCNALDGKCTISCDNEDIKCYLIDNNGFILVSEDTSQTNLFFGKVEGA 878

  Fly   988 IMDSLVQDRIYKRVTVNDYQGVCSDADNPYTAAGGILKPNRLGSWFFNHLLALSAAWLSLMPASL 1052
            :|:.|:....:|::.:.|||.:|.:......:|..:|.|.....|....|:      :.|:..:|
Zfish   879 VMNKLLLMGSFKKINLYDYQALCKEYAGSSDSARTLLDPFTTVKWLLTELV------IFLLEFNL 937

  Fly  1053 RAWPQEEYTYDNEDVVFVDNNYSDEYEFGNENEYNMQVDQEMDEFFTTADVEYTTPPPRQHKPHV 1117
            .:|    :..|:                      .::..:.........|.||
Zfish   938 YSW----WNCDS----------------------TVKAQRSQRTMMVPCDTEY------------ 964

  Fly  1118 GPRFSPDPHNARRCDLRTDLYMLQPERLNQGGQNNPLKGKLTNCHVSGCERPFSVQKIPHSNLIL 1182
             |.|..:         ||                  :|....|...:||.|.|.:|:||.|||.:
Zfish   965 -PAFVSE---------RT------------------IKETTGNIDCNGCIRTFVIQQIPSSNLFM 1001

  Fly  1183 LVVDTLCPCGSK-QLDIEPLEEAGVIGACSTRRQGQE-QESRRRPKKCINYHPEEIEIQQCGRGS 1245
            :||:..|.|||. .:.:||:|   :|...|.:....: |:.||||:.|..:||||..: :||..:
Zfish  1002 VVVENKCDCGSALPVTMEPIE---IIYNESLKCDRLKFQKDRRRPQSCHPFHPEENAV-ECGSAN 1062

  Fly  1246 TLLHMSGSVIVAHLLMV 1262
            .|.....::::..|.:|
Zfish  1063 ALSFPLVAILIPALSLV 1079

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
stol	NP_001188817.2	VWA_N	130..230	CDD:462464	37/99 (37%)
		vWA_VGCC_like	245..428	CDD:238740	77/182 (42%)
		PDC2_MCP_like	511..643	CDD:350337	50/131 (38%)
		VGCC_alpha2	810..>1048	CDD:462488	70/248 (28%)
cacna2d3	XP_073773099.1	None