Protein Alignment CG4587 and cacna2d3

DIOPT Version :9

• Sequence 1: NP_001188817.2
• Gene: CG4587 / 34921
• FlyBaseID: FBgn0028863
• Length: 1271
• Species: Drosophila melanogaster
• Sequence 2: XP_017213852.1
• Gene: cacna2d3 / 100148645
• ZFINID: ZDB-GENE-030616-133
• Length: 1083
• Species: Danio rerio
• Alignment Length: 1257
• Identity: 370/1257 - (29%)
• Similarity: 593/1257 - (47%)
• Gaps: 231/1257 - (18%)

  Fly    33 DIPHNEVRNWALKFGVDLWEFGRQFTKMNEIKSRFK--DNDIEVKRKDGIILLRELAAEVKNFMD 95
            :||.:.|:.||..||.::.....:::....::.::|  :..:.::..||..|::.||..::....
Zfish    31 EIPLSVVKLWASAFGGEIKSIASKYSGSQLLQKKYKEYEKSVRIEEIDGAKLVKNLAQNMEEMFR 95

  Fly    96 FKRNAVMRLMDSAEQAALSELEGQGQAESPMGGQQHYDARRINEYNADGKLADGARHMDIRFMRR 160
            .|..|..||:::||:|.|.      ..|:|....::::|..|||.:.||...:......:.....
Zfish    96 KKAEATRRLVEAAEEAHLQ------HEENPDLQYEYFNAVLINEVDEDGNSVELGGEFLLEPNDH 154

  Fly   161 FERLPVNLSLSSILVPHGVDLDEPDVKSALQWSGHLDPLFQNNLEQDPALSWQYFGSSTGFLRRF 225
            |..|.||||||.:.||..:...:||:.:.:.||..|:.:|.:|..:||.|.||||||:.||.|::
Zfish   155 FNNLSVNLSLSVVQVPTNMYNKDPDIVNGVYWSEALNKVFVDNFRRDPTLIWQYFGSAKGFFRQY 219

  Fly   226 PGTAWPPEGSKGSKLIHDFRTHNWFVQAASSPKDIMILLDASSSMTEKSFDLGMATAFNILDTLG 290
            ||..|.|:  :...:..|.|...|::|||:||||::||:|.|.||......:...|..:||||||
Zfish   220 PGVKWYPD--EHGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGLRLTIARQTVASILDTLG 282

  Fly   291 EDDFVNLITFSEVVKTPVPCFKDRMVRATPDNIQEIKSAVKAIKLQDTANFTAGLEYAFSLLHKY 355
            :|||.|:|.:::.:....||....:|:|...|....|..:..:..:........|..||::|::.
Zfish   283 DDDFFNIIAYNQEIHYVEPCLNGTLVQADSTNKDHFKEHLDKLFAKGIGLLGNALSEAFTILNEI 347

  Fly   356 NQSGAGSQCNQAIMLITESTSESHKDVIKQYNWPHMPVRIFTYLIGSDSGSRSNLHDMACSNKGF 420
            ||:|.||.|:|||||||:..:|.:.||..:||||...||||.||||.:|....||..|||:|||:
Zfish   348 NQTGRGSSCSQAIMLITDGATEMYDDVFAKYNWPERKVRIFPYLIGRESAFADNLKWMACANKGY 412

  Fly   421 FVQINDYDEARRKVIDYALVMARPMIMYQADHPVHWSPVFV------AGKSGGLGRDSEYQRRLV 479
            |.||:...:.:..|:.|..||:||.:: ..:|...|:..:|      |.|..|..:..    ..:
Zfish   413 FSQISTLADVQENVMRYLHVMSRPKVI-DHEHDTVWTEAYVDSALAQAHKQLGENKGP----NPM 472

  Fly   480 TTVSTPVFDRRNHSVRVANLLGVVGTDVPIEEIRKVIPQHKLGPNGYSFIVDNNGRVLYHPDLRP 544
            |||:.|||..:|.:.....||||.|||:||:|:.||||:||||.:||:|.:.:||.:|.||||||
Zfish   473 TTVAMPVFSTKNETKNQGILLGVAGTDIPIQELMKVIPKHKLGIHGYAFAITSNGYLLLHPDLRP 537

  Fly   545 LGDANQYIDQLKPKYASVDITELELPETEFGNNNEPIEINKNLLNEMRGDMIKPKEGETEFTVMN 609
            |....|  .:.||.|:|||::|:|..:||               :.:|..|:..|.|.....|..
Zfish   538 LYQEGQ--KRKKPSYSSVDLSEVEWEDTE---------------DVLRTAMVNRKTGTFSMEVKR 585

  Fly   610 HYDDSKRVSTRTHRYFYGPIEDTPFTLAIVLPEKYGSHEFVSQQEIRHSRNNVTEYFKGDNWRVH 674
            ..|..|||.|..:.|:|..|:.|||::.:.|...:|.:                 :|||:
Zfish   586 TVDKGKRVLTMHNDYYYTDIKGTPFSVGVALSRGHGKY-----------------FFKGN----- 628

  Fly   675 PDWVYCEYNSVSDLEKERESSGEYSSRDQEPSFGSPEEQVLHFLSRAGRPGWKWMSVRPKSPQPH 739
               |..| ..:.|||              :|.....:|             |.:.:    :.:.|
Zfish   629 ---VSLE-AGLHDLE--------------QPDVALADE-------------WTYCT----TEEHH 658

  Fly   740 HNMHSGSNGGNAPGSSHFGSQHQSSQ---GSRKAEPYF-CDRALLQSLVRDAMVTDGLDRNTTGS 800
            .:.|.              :|.|:.:   .|||  |:| |||.|:|.::.||:||..::...||
Zfish   659 EHRHL--------------TQVQAIKIYMTSRK--PHFKCDRELIQQVLFDAVVTAPVEAYWTG- 706

  Fly   801 SSGKEDKHPIATLMAILKRQGYQKFVVATSFVATRSGLLRWIDHVKRPEDTPEPHFSEDNVRAMD 865
                         :|:.|.:...| .|..:|:.||:||.|....|     .||...:.|.:.|.|
Zfish   707 -------------LALNKSENSDK-GVEIAFLGTRTGLSRTNLFV-----VPEQLTNRDFLTAED 752

  Fly   866 TS----------WYKRAIDQHSVEPDSFVYSVPFGSGYAIKSNATLVTASHAIFVEHRGHKAAAG 920
            ..          |||||.:|   .|.:||||:||.||   ..|.::|.||.||.:..........
Zfish   753 KEGVFNADHFPLWYKRAAEQ---VPGTFVYSIPFSSG---GENKSVVLASTAIQLLDDRKSPIVA 811

  Fly   921 VVGLQFQHDSLAKHFINITSACTGMTG-CKRTCASDNLDCYVLDNSGFVIISEEMEHTGKFFGQI 984
            .||:|.:.:...:.|...:..|..:.| |..:|.::::.||::||:||:::||:...|..|||::
Zfish   812 AVGIQMKLEFFQRKFWTASRQCNALDGKCTISCDNEDIKCYLIDNNGFILVSEDTSQTNLFFGKV 876

  Fly   985 DGTIMDSLVQDRIYKRVTVNDYQGVCSDADNPYTAAGGILKPNRLGSWFFNHLLALSAAWLSLMP 1049
            :|.:|:.|:....:|::.:.|||.:|.:......:|..:|.|.....|....|:      :.|:.
Zfish   877 EGAVMNKLLLMGSFKKINLYDYQALCKEYAGSSDSARTLLDPFTTVKWLLTELV------IFLLE 935

  Fly  1050 ASLRAWPQEEYTYDNEDVVFVDNNYSDEYEFGNENEYNMQVDQEMDEFFTTADVEYTTPPPRQHK 1114
            .:|.:|    :..|:                      .::..:.........|.||
Zfish   936 FNLYSW----WNCDS----------------------TVKAQRSQRTMMVPCDTEY--------- 965

  Fly  1115 PHVGPRFSPDPHNARRCDLRTDLYMLQPERLNQGGQNNPLKGKLTNCHVSGCERPFSVQKIPHSN 1179
                |.|..:         ||                  :|....|...:||.|.|.:|:||.||
Zfish   966 ----PAFVSE---------RT------------------IKETTGNIDCNGCIRTFVIQQIPSSN 999

  Fly  1180 LILLVVDTLCPCGSK-QLDIEPLEEAGVIGACSTRRQGQE-QESRRRPKKCINYHPEEIEIQQCG 1242
            |.::||:..|.|||. .:.:||:|   :|...|.:....: |:.||||:.|..:||||..: :||
Zfish  1000 LFMVVVENKCDCGSALPVTMEPIE---IIYNESLKCDRLKFQKDRRRPQSCHPFHPEENAV-ECG 1060

  Fly  1243 RGSTLLHMSGSVIVAHL-LMVT 1263
            ..:.|.....::::..| ||::
Zfish  1061 SANALSFPLVAILIPALSLMIS 1082

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4587	NP_001188817.2	VWA_N	108..230	CDD:285584	43/121 (36%)
		vWA_VGCC_like	245..428	CDD:238740	77/182 (42%)
		Cache_1	456..544	CDD:280839	40/93 (43%)
		VGCC_alpha2	590..>647	CDD:285647	18/56 (32%)
cacna2d3	XP_017213852.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	109	1.000	Domainoid score	I6280
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	572	1.000	Inparanoid score	I1017
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110668at33208
OrthoFinder	1	1.000	-	-		FOG0000496
OrthoInspector	1	1.000	-	-		mtm6553
orthoMCL	1	0.900	-	-		OOG6_103783
Panther	1	1.100	-	-	O	PTHR10166
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X365
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.970