DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18480 and Lrrc15

DIOPT Version :9

Sequence 1:	NP_001285960.1	Gene:	CG18480 / 34920	FlyBaseID:	FBgn0028518	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	NP_083249.1	Gene:	Lrrc15 / 74488	MGIID:	1921738	Length:	579	Species:	Mus musculus

Alignment Length:	610	Identity:	135/610 - (22%)
Similarity:	209/610 - (34%)	Gaps:	197/610 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LKQILLYVGLLLCVLLQVCRSKTQSQMF--CPTVCHCDLHAQRNRAVCSAKRLISANIEIPTTVE 77
            ||..||        ||..|::......:  ||:.|.|   ::.::..|:..::::....:|....
Mouse     3 LKHYLL--------LLVSCQAWAAGLAYYGCPSECTC---SRASQVECTGAQIVAMPSPLPWNAM 56

  Fly    78 LLDLSYNDITTIDDDSFKTTIHLLNLTLAHNAIHTLYGDAFVELTRLRYLDLSYNRLEQID---- 138
            .|.:....||.:.:|.|.....|:.|.:..|.:..:...||..|..||:|.|:.|:|:.:.
Mouse    57 SLQILNTHITELPEDKFLNISALIALKMEKNELANIMPGAFRNLGSLRHLSLANNKLKNLPVRLF 121

  Fly   139 ------EHILESNNQLI--------------HLNLEGNKLSTLGKGPILRSPSLRSLNLRNS--- 180
                  |.:|.|||||:              .|.|.||.|..:.:|.......|..|||.|:
Mouse   122 QDVNNLETLLLSNNQLVQIQPAQFSQFSNLKELQLYGNNLEYIPEGVFDHLVGLTKLNLGNNGFT 186

  Fly   181 -------------QVNQLGTQLLSALP--------QLRQLDLAQNLLLTLSPGDFHAPRNLASLN 224
                         ||.:|....||.:|        .|::|.|.:|.:.|||||.||..|||..|.
Mouse   187 HLSPRVFQHLGNLQVLRLYENRLSDIPMGTFDALGNLQELALQENQIGTLSPGLFHNNRNLQRLY 251

  Fly   225 VEENPFNCDRALAKVATGLRQRGVAIFMSNCMEEEVQDHQDDAEAVNFPNKNEKF---ESMEYLE 286
            :..|      .::.:..|       |||                  ..|:.|:..   .|::.|.
Mouse   252 LSNN------HISHLPPG-------IFM------------------QLPHLNKLTLFGNSLKELS 285

  Fly   287 PSTRGPQSVLSVWRDLDSSEEQNSSQDDEQMSSLSDVCEGSREKLCLRYRICLERVSHELLA--- 348
            |...||...|   |:|.......:|..|...|.|:.:     :.|.|         ||..|:
Mouse   286 PGVFGPMPNL---RELWLYNNHITSLPDNAFSHLNQL-----QVLIL---------SHNQLSYIS 333

  Fly   349 ----GGNSQLEDEIIRTHTYDEDDLKLAFVVGGATGVCM----------VIF-----IITFAL-- 392
                .|.:.|.:..:.|:...:.|..:...:.....|.:          .||     ::|..|
Mouse   334 PGAFNGLTNLRELSLHTNALQDLDGNVFRSLANLRNVSLQNNRLRQLPGSIFANVNGLMTIQLQN 398

  Fly   393 ------------CLKSCCEMRKKKSNPEVATGVSAPLNPSQDSLPTIHTW-SPQRTR-----NPR 439
                        .|.:.||:|...:          |.....:.|| :|.| ...|.|     .|.
Mouse   399 NNLENLPLGIFDHLGNLCELRLYDN----------PWRCDSNILP-LHDWLILNRARLGTDTLPV 452

  Fly   440 RSNPQRPRSTQSHAVVRQPY------GPQDNFVSRLFGRPARSQYYRTINQNTATLIRRLSRSNL 498
            .|:|...|. ||..::...:      ||:         .|..|.|..|.:...:|.|
Mouse   453 CSSPASVRG-QSLVIINVNFPGPSVQGPE---------TPEVSSYPDTSSYPDSTSI-------- 499

  Fly   499 FTSRDREPSSPAEPPTSTARFYTDV 523
                    ||..|...||...|||:
Mouse   500 --------SSTTEITRSTDDDYTDL 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18480	NP_001285960.1	LRR_8	74..134	CDD:290566	16/59 (27%)
		LRR_RI	<76..230	CDD:238064	57/201 (28%)
		leucine-rich repeat	76..99	CDD:275380	5/22 (23%)
		leucine-rich repeat	100..123	CDD:275380	6/22 (27%)
		LRR_8	122..182	CDD:290566	24/99 (24%)
		leucine-rich repeat	124..147	CDD:275380	10/32 (31%)
		leucine-rich repeat	148..171	CDD:275380	7/36 (19%)
		LRR_8	170..230	CDD:290566	27/83 (33%)
		leucine-rich repeat	172..195	CDD:275380	11/46 (24%)
		leucine-rich repeat	196..219	CDD:275380	11/22 (50%)
Lrrc15	NP_083249.1	LRR 1	54..75		5/20 (25%)
		leucine-rich repeat	58..78	CDD:275380	5/19 (26%)
		LRR 2	78..99		5/20 (25%)
		PLN00113	82..>401	CDD:215061	83/366 (23%)
		LRR 3	102..123		6/20 (30%)
		leucine-rich repeat	103..126	CDD:275380	6/22 (27%)
		LRR 4	126..147		7/20 (35%)
		leucine-rich repeat	127..150	CDD:275380	7/22 (32%)
		LRR 5	150..171		6/20 (30%)
		leucine-rich repeat	151..174	CDD:275380	6/22 (27%)
		LRR 6	174..195		5/20 (25%)
		leucine-rich repeat	175..198	CDD:275380	5/22 (23%)
		LRR 7	198..219		6/20 (30%)
		leucine-rich repeat	199..222	CDD:275380	6/22 (27%)
		LRR 8	222..243		10/20 (50%)
		leucine-rich repeat	223..246	CDD:275380	11/22 (50%)
		LRR 9	246..267		8/51 (16%)
		leucine-rich repeat	247..270	CDD:275380	7/53 (13%)
		LRR 10	270..291		4/20 (20%)
		leucine-rich repeat	271..294	CDD:275380	6/22 (27%)
		LRR 11	294..315		5/23 (22%)
		leucine-rich repeat	295..318	CDD:275380	7/25 (28%)
		LRR 12	318..339		5/34 (15%)
		leucine-rich repeat	319..342	CDD:275380	6/36 (17%)
		LRR 13	342..363		3/20 (15%)
		leucine-rich repeat	343..364	CDD:275380	3/20 (15%)
		LRR 14	366..387		3/20 (15%)
		leucine-rich repeat	367..387	CDD:275380	3/19 (16%)
		LRR 15	390..411		2/20 (10%)
		leucine-rich repeat	391..412	CDD:275380	2/20 (10%)
		LRRCT	423..>462	CDD:214507	11/50 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	476..509		11/57 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910