DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18480 and LRTM1

DIOPT Version :9

Sequence 1:	NP_001285960.1	Gene:	CG18480 / 34920	FlyBaseID:	FBgn0028518	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	NP_065729.1	Gene:	LRTM1 / 57408	HGNCID:	25023	Length:	345	Species:	Homo sapiens

Alignment Length:	189	Identity:	56/189 - (29%)
Similarity:	90/189 - (47%)	Gaps:	11/189 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 QILLYVGLLLCVLLQVCRSKTQSQMFCPTVCHCDLHAQRNRAVCSAKRLISANIEIPTTVELLDL 81
            ::||:..::  |||||..|       ||..|:|  .:..|...||.:.|......:|.....|.|
Human     4 ELLLFSSVI--VLLQVVCS-------CPDKCYC--QSSTNFVDCSQQGLAEIPSHLPPQTRTLHL 57

  Fly    82 SYNDITTIDDDSFKTTIHLLNLTLAHNAIHTLYGDAFVELTRLRYLDLSYNRLEQIDEHILESNN 146
            ..|.|..:...:|::...|:.|.|::|::..|...||..|..|:.|:|:.|.|..::..:..|..
Human    58 QDNQIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLESRLFHSLP 122

  Fly   147 QLIHLNLEGNKLSTLGKGPILRSPSLRSLNLRNSQVNQLGTQLLSALPQLRQLDLAQNL 205
            ||..|:|..|.:|.|.........:|..|.::.:|:.||...||.::|.:|.|.|..||
Human   123 QLRELDLSSNNISHLPTSLGETWENLTILAVQQNQLQQLDRALLESMPSVRLLLLKDNL 181

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18480	NP_001285960.1	LRR_8	74..134	CDD:290566	17/59 (29%)
		LRR_RI	<76..230	CDD:238064	39/130 (30%)
		leucine-rich repeat	76..99	CDD:275380	5/22 (23%)
		leucine-rich repeat	100..123	CDD:275380	8/22 (36%)
		LRR_8	122..182	CDD:290566	15/59 (25%)
		leucine-rich repeat	124..147	CDD:275380	6/22 (27%)
		leucine-rich repeat	148..171	CDD:275380	6/22 (27%)
		LRR_8	170..230	CDD:290566	13/36 (36%)
		leucine-rich repeat	172..195	CDD:275380	7/22 (32%)
		leucine-rich repeat	196..219	CDD:275380	5/10 (50%)
LRTM1	NP_065729.1	leucine-rich repeat	34..51	CDD:275380	4/16 (25%)
		LRR_8	50..134	CDD:290566	24/83 (29%)
		LRR 1	51..72		5/20 (25%)
		leucine-rich repeat	52..75	CDD:275380	5/22 (23%)
		LRR 2	75..96		7/20 (35%)
		leucine-rich repeat	76..99	CDD:275380	8/22 (36%)
		LRR_4	98..139	CDD:289563	13/40 (33%)
		LRR 3	99..120		5/20 (25%)
		leucine-rich repeat	100..123	CDD:275380	6/22 (27%)
		LRR_8	122..181	CDD:290566	18/58 (31%)
		LRR 4	123..144		7/20 (35%)
		leucine-rich repeat	124..147	CDD:275380	6/22 (27%)
		LRR 5	147..168		7/20 (35%)
		leucine-rich repeat	148..171	CDD:275380	7/22 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	326..345
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000