DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18480 and LRRC24

DIOPT Version :9

Sequence 1:	NP_001285960.1	Gene:	CG18480 / 34920	FlyBaseID:	FBgn0028518	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	NP_001019849.2	Gene:	LRRC24 / 441381	HGNCID:	28947	Length:	513	Species:	Homo sapiens

Alignment Length:	485	Identity:	109/485 - (22%)
Similarity:	161/485 - (33%)	Gaps:	135/485 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 CPTVCHCDLHAQRNRAVCSAKRLISANIEIPTTVELLDLSYNDITTIDDDSFKTTIHLLNLTLAH 107
            ||..|.|    ......|.|.||....:.||...:.|.|..|:|..::..:......|..|.|.:
Human    23 CPAACRC----YSATVECGALRLRVVPLGIPPGTQTLFLQDNNIARLEPGALAPLAALRRLYLHN 83

  Fly   108 NAIHTLYGDAFVELTRLRYLDLSYNRLEQIDEHILESNNQLIHLNLEGNKLSTLGKGPILRSPSL 172
            |::..|...||....||..|.|:.|||..:.........||..|.|.||:|:.|.....|..|.|
Human    84 NSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVGLAQLRVLYLAGNQLARLLDFTFLHLPRL 148

  Fly   173 RSLNLRNSQVNQLGTQLLSALPQLRQLDLAQNLLLTLSPGDFHAPRNLASLNVEENPFNCDRALA 237
            :.|:|:.:.:..|..|.|:.|..|..|||::|.|.|:|........:|..|.:.|||:.||.||.
Human   149 QELHLQENSIELLEDQALAGLSSLALLDLSRNQLGTISREALQPLASLQVLRLTENPWRCDCALH 213

  Fly   238 KVATGLRQRGVAIFMSNCMEEEVQDHQDDAEAVNFPNKNEKFESMEYLEPSTRGPQSVLSVWRDL 302
            .:...:::.|..:..|                        :...:...||.....||:|
Human   214 WLGAWIKEGGQRLLTS------------------------RDRKIMCAEPPRLALQSLL------ 248

  Fly   303 DSSEEQNSSQDDEQMSSLSDVCEGSREKLCLRYRICLERVSH----ELLAGGNSQLEDEIIRTHT 363
                       |...|||                ||:....|    ||.|...
Human   249 -----------DVSHSSL----------------ICIPPSVHVQPLELTANLG------------ 274

  Fly   364 YDEDDLKLAFVVGGATGVCMVIFIITFALCLKSCCEMRKKKSNPEVATGVSAPLNPSQDSLPTIH 428
               :||::|                         |:          |:|...||          .
Human   275 ---EDLRVA-------------------------CQ----------ASGYPQPL----------V 291

  Fly   429 TWSPQRTRNPRRSNPQRPRSTQSHAVVRQPYGPQDN-----FVSRLFGRPARSQYYRTINQNTAT 488
            ||  ::...||...|:.....:...:....:...|.     |:|.:  ..|.:..|.....|...
Human   292 TW--RKVPQPREGRPRAQAQLEGGLLGLGGHSASDTGSGMLFLSNI--TLAHAGKYECEASNAGG 352

  Fly   489 LIRRLSRSNLFTSRDREPSSPAEPPTSTAR 518
            ..|...|..:..|| ::|..||:||...||
Human   353 AARVPFRLLVNASR-QQPQQPAQPPPPAAR 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18480	NP_001285960.1	LRR_8	74..134	CDD:290566	16/59 (27%)
		LRR_RI	<76..230	CDD:238064	47/153 (31%)
		leucine-rich repeat	76..99	CDD:275380	4/22 (18%)
		leucine-rich repeat	100..123	CDD:275380	7/22 (32%)
		LRR_8	122..182	CDD:290566	20/59 (34%)
		leucine-rich repeat	124..147	CDD:275380	6/22 (27%)
		leucine-rich repeat	148..171	CDD:275380	8/22 (36%)
		LRR_8	170..230	CDD:290566	20/59 (34%)
		leucine-rich repeat	172..195	CDD:275380	7/22 (32%)
		leucine-rich repeat	196..219	CDD:275380	8/22 (36%)
LRRC24	NP_001019849.2	LRR_RI	49..>158	CDD:238064	32/108 (30%)
		LRR_8	<50..86	CDD:290566	8/35 (23%)
		LRR 1	51..72		4/20 (20%)
		leucine-rich repeat	53..75	CDD:275380	4/21 (19%)
		LRR 2	75..96		7/20 (35%)
		LRR_8	76..134	CDD:290566	20/57 (35%)
		leucine-rich repeat	76..99	CDD:275380	7/22 (32%)
		LRR 3	99..120		7/20 (35%)
		leucine-rich repeat	100..123	CDD:275380	6/22 (27%)
		LRR_8	123..205	CDD:290566	28/81 (35%)
		LRR 4	123..144		8/20 (40%)
		leucine-rich repeat	124..147	CDD:275380	8/22 (36%)
		LRR 5	147..168		6/20 (30%)
		leucine-rich repeat	148..171	CDD:275380	7/22 (32%)
		LRR 6	171..192		8/20 (40%)
		leucine-rich repeat	172..195	CDD:275380	8/22 (36%)
		LRRCT	204..257	CDD:214507	17/109 (16%)
		Ig	259..364	CDD:299845	25/168 (15%)
		IG_like	266..362	CDD:214653	24/159 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	365..391		9/18 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910