DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18480 and Tl

DIOPT Version :9

Sequence 1:	NP_001285960.1	Gene:	CG18480 / 34920	FlyBaseID:	FBgn0028518	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	NP_001262995.1	Gene:	Tl / 43222	FlyBaseID:	FBgn0262473	Length:	1117	Species:	Drosophila melanogaster

Alignment Length:	214	Identity:	62/214 - (28%)
Similarity:	91/214 - (42%)	Gaps:	45/214 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 KRLISANIEIPTTVELLDLSYNDITTIDDDSFKTTIHLLNLTLAHNAIHTLYGDAFVELTRLRYL 127
            |.|.:..:|....:..||||.|.:|.:.|..|..|.:|.:|.|..|.:..:.||.|..|..|..|
  Fly   355 KTLPATLLEHQVNLLSLDLSNNRLTHLPDSLFAHTTNLTDLRLEDNLLTGISGDIFSNLGNLVTL 419

  Fly   128 DLSYNRLEQIDEHILESNNQLIHLNLEGNKLSTLGKGPIL--------RSP-----SLRSLNLRN 179
            .:|.|||..||.....|.|.|.||:|:.|.:..  :.|:|        .||     .|.:|||||
  Fly   420 VMSRNRLRTIDSRAFVSTNGLRHLHLDHNDIDL--QQPLLDIMLQTQINSPFGYMHGLLTLNLRN 482

  Fly   180 SQVNQLGTQLLSALPQLRQLDLAQNLLLTLS--------------------------PGDFHA-- 216
            :.:..:.....:.:.|||:|||:.|.:.:|.                          |.|.|.
  Fly   483 NSIIFVYNDWKNTMLQLRELDLSYNNISSLGYEDLAFLSQNRLHVNMTHNKIRRIALPEDVHLGE 547

  Fly   217 --PRNLASLNVEENPFNCD 233
              ..||..:::.:||..||
  Fly   548 GYNNNLVHVDLNDNPLVCD 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18480	NP_001285960.1	LRR_8	74..134	CDD:290566	21/59 (36%)
		LRR_RI	<76..230	CDD:238064	56/196 (29%)
		leucine-rich repeat	76..99	CDD:275380	9/22 (41%)
		leucine-rich repeat	100..123	CDD:275380	8/22 (36%)
		LRR_8	122..182	CDD:290566	25/72 (35%)
		leucine-rich repeat	124..147	CDD:275380	9/22 (41%)
		leucine-rich repeat	148..171	CDD:275380	9/35 (26%)
		LRR_8	170..230	CDD:290566	21/94 (22%)
		leucine-rich repeat	172..195	CDD:275380	6/22 (27%)
		leucine-rich repeat	196..219	CDD:275380	10/52 (19%)
Tl	NP_001262995.1	LRR_8	174..233	CDD:290566
		leucine-rich repeat	176..198	CDD:275380
		leucine-rich repeat	199..222	CDD:275380
		LRR_RI	216..542	CDD:238064	54/188 (29%)
		LRR_8	221..281	CDD:290566
		leucine-rich repeat	223..270	CDD:275380
		leucine-rich repeat	271..294	CDD:275380
		leucine-rich repeat	295..320	CDD:275380
		leucine-rich repeat	321..343	CDD:275380
		LRR_8	342..402	CDD:290566	16/46 (35%)
		leucine-rich repeat	344..367	CDD:275380	3/11 (27%)
		leucine-rich repeat	368..391	CDD:275380	9/22 (41%)
		LRR_8	390..450	CDD:290566	23/59 (39%)
		leucine-rich repeat	392..415	CDD:275380	8/22 (36%)
		leucine-rich repeat	416..439	CDD:275380	9/22 (41%)
		leucine-rich repeat	440..474	CDD:275380	9/35 (26%)
		leucine-rich repeat	475..498	CDD:275380	6/22 (27%)
		LRR_8	477..534	CDD:290566	13/56 (23%)
		leucine-rich repeat	499..520	CDD:275380	7/20 (35%)
		leucine-rich repeat	523..552	CDD:275380	3/28 (11%)
		LRRCT	561..619	CDD:214507	4/6 (67%)
		LRRNT	631..667	CDD:214470
		leucine-rich repeat	664..693	CDD:275380
		LRR_8	669..726	CDD:290566
		leucine-rich repeat	694..715	CDD:275380
		leucine-rich repeat	716..737	CDD:275380
		LRRCT	751..800	CDD:214507
		TIR	858..996	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453770
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930