DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18480 and Toll-6

DIOPT Version :9

Sequence 1:	NP_001285960.1	Gene:	CG18480 / 34920	FlyBaseID:	FBgn0028518	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster

Alignment Length:	302	Identity:	70/302 - (23%)
Similarity:	114/302 - (37%)	Gaps:	109/302 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 LLDLSYNDITTIDDDSFKTTIHLLNLTLAHNAIHTLYGDAFVELTRLRYLDLSYNRLEQIDEHIL 142
            ||:||:|.:|.::.:.|.....|..|.|.||.:..:..|.|..:..|..|.||:|:|:.:|.:.|
  Fly   404 LLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHNKLKYLDAYAL 468

  Fly   143 E----------SNNQLI--------------HLNLEGNKLSTLGKGPI-LRS-PSLRSLNLRNSQ 181
            .          .||.||              .|||.||:|.|:   |: ||: ..||:::|..:.
  Fly   469 NGLYVLSLLSLDNNALIGVHPDAFRNCSALQDLNLNGNQLKTV---PLALRNMRHLRTVDLGENM 530

  Fly   182 V------------NQLGTQLLS------------ALPQLRQLDLAQNLLLTLSPGDFHAPRNLAS 222
            :            |..|.:|:.            .||.|:.|:||:|.:..:.||.|....::.:
  Fly   531 ITVMEDSAFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRIAVVEPGAFEMTSSIQA 595

  Fly   223 LNVEENPFNCDRALAKVATGLRQRGVAIFMSNCMEEEVQDHQDDAEAVNFPN------KNEKFES 281
            :.::.|..|....|..                                |.|:      .:.:.||
  Fly   596 VRLDGNELNDINGLFS--------------------------------NMPSLLWLNISDNRLES 628

  Fly   282 MEYLE-PSTRGPQSVLSVWRDLDSSEEQNSSQDDEQMSSLSD 322
            .:|.. |||       ..|.||..:          ::||||:
  Fly   629 FDYGHVPST-------LQWLDLHKN----------RLSSLSN 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18480	NP_001285960.1	LRR_8	74..134	CDD:290566	19/55 (35%)
		LRR_RI	<76..230	CDD:238064	53/201 (26%)
		leucine-rich repeat	76..99	CDD:275380	7/20 (35%)
		leucine-rich repeat	100..123	CDD:275380	7/22 (32%)
		LRR_8	122..182	CDD:290566	25/85 (29%)
		leucine-rich repeat	124..147	CDD:275380	9/32 (28%)
		leucine-rich repeat	148..171	CDD:275380	12/38 (32%)
		LRR_8	170..230	CDD:290566	17/83 (20%)
		leucine-rich repeat	172..195	CDD:275380	7/46 (15%)
		leucine-rich repeat	196..219	CDD:275380	8/22 (36%)
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380
		LRR_8	171..236	CDD:290566
		leucine-rich repeat	172..201	CDD:275380
		leucine-rich repeat	202..278	CDD:275380
		leucine-rich repeat	229..249	CDD:275380
		LRR_RI	278..468	CDD:238064	21/63 (33%)
		leucine-rich repeat	279..302	CDD:275380
		LRR_8	301..386	CDD:290566
		leucine-rich repeat	303..326	CDD:275380
		leucine-rich repeat	327..350	CDD:275380
		LRR	350..729	CDD:227223	70/302 (23%)
		leucine-rich repeat	352..375	CDD:275380
		leucine-rich repeat	376..401	CDD:275380
		LRR_RI	<401..626	CDD:238064	57/256 (22%)
		leucine-rich repeat	402..425	CDD:275380	7/20 (35%)
		leucine-rich repeat	426..449	CDD:275380	7/22 (32%)
		leucine-rich repeat	450..473	CDD:275380	8/22 (36%)
		leucine-rich repeat	474..497	CDD:275380	4/22 (18%)
		leucine-rich repeat	498..518	CDD:275380	10/22 (45%)
		leucine-rich repeat	521..544	CDD:275380	3/22 (14%)
		leucine-rich repeat	545..566	CDD:275380	2/20 (10%)
		leucine-rich repeat	569..592	CDD:275380	8/22 (36%)
		leucine-rich repeat	593..615	CDD:275380	4/53 (8%)
		leucine-rich repeat	616..637	CDD:275380	4/20 (20%)
		leucine-rich repeat	638..662	CDD:275380	7/26 (27%)
		leucine-rich repeat	663..684	CDD:275380
		leucine-rich repeat	685..708	CDD:275380
		leucine-rich repeat	709..728	CDD:275380
		LRR_8	883..943	CDD:290566
		leucine-rich repeat	885..908	CDD:275380
		leucine-rich repeat	909..932	CDD:275380
		LRR_8	932..990	CDD:290566
		leucine-rich repeat	933..956	CDD:275380
		TIR	1114..1247	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453802
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840