DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18480 and CG42709

DIOPT Version :9

Sequence 1:	NP_001285960.1	Gene:	CG18480 / 34920	FlyBaseID:	FBgn0028518	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	NP_001163434.1	Gene:	CG42709 / 39453	FlyBaseID:	FBgn0261674	Length:	458	Species:	Drosophila melanogaster

Alignment Length:	422	Identity:	88/422 - (20%)
Similarity:	151/422 - (35%)	Gaps:	87/422 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 RSKTQSQMFCPTVCHC--DLHAQRNRAVCSAKRLISANIEIPTTVELLDLSYNDITTIDDDSFKT 96
            ||....:..||..|.|  |....:    |:...|....:::|.|..::|||:|.|..:..:.|..
  Fly    84 RSNHVLEPSCPRNCLCLEDFKFVQ----CANAHLTHVPLDMPKTAAIIDLSHNVIAELRPEDFAN 144

  Fly    97 TIHLLNLTLAHNAIHTLYGDAFVELTRLRYLDLSYNRLEQIDEHILESNNQLIHLNLEGNKLSTL 161
            ....:.:.|.||.|.::..|.|....||:.|.|:.|||.:||.....:..:|..|:|..|.::..
  Fly   145 LSRAVEINLNHNLISSIDKDVFQGSERLKRLRLANNRLTKIDPDTFAAAKELTLLDLSNNTITQR 209

  Fly   162 GKGPILRSPSLRSLNLRNSQVNQLGTQLLSALPQLRQLDLAQNLLLTLSPGDFHAPRNLASLNVE 226
            ..|..|..|.|...:..|....:|..|....:..|..|.|.:|        ||....|..:.:
  Fly   210 LDGSFLNQPDLVEFSCVNCSWTELPEQTFQNMSGLEVLRLNKN--------DFKQQINTKAFS-- 264

  Fly   227 ENPFNCDRALAKV----ATGLRQRGVAIFMSNCMEEEVQDHQDDAEAVNFPNKNEKFESMEYL-- 285
                    .|.|:    ...|.|:.:         ||:.......:.::|.|.:  ....|::
  Fly   265 --------PLTKIIKLKLPELEQQNI---------EELCSLLTSIDTISFLNYD--ISCYEFVLG 310

  Fly   286 -----------EPSTRG---PQSVLSVWR-----DLDSSEEQNSSQDDEQMSSLSDVCEGSREKL 331
                       ||..:|   |..|.|:..     ....:..::::::..:|.:.:::.:..
  Fly   311 TPFNGSLIYPTEPPLKGITNPPIVASITSTAKPVTATPAPPRSANRNRGKMDNSTELVKAG---- 371

  Fly   332 CLRYRICLERVSHELLAGGNS---QLEDEIIRTHTYDEDDLKLAFVVGGATGVCMVIFIITFALC 393
            .|........||.|..|...:   |:..|.|.|       |.:..:      |..||.|:...:|
  Fly   372 ILSSETSTSGVSVEPPAESQTNQVQISQEAINT-------LLICIM------VLAVIGIVIGLIC 423

  Fly   394 LK-------SCCEMRKKKSNPEVATGVSAPLN 418
            .:       .||...|.:...:|......|||
  Fly   424 RQDIGGIKTKCCRTSKPEPKDQVHPTEEIPLN 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18480	NP_001285960.1	LRR_8	74..134	CDD:290566	18/59 (31%)
		LRR_RI	<76..230	CDD:238064	39/153 (25%)
		leucine-rich repeat	76..99	CDD:275380	6/22 (27%)
		leucine-rich repeat	100..123	CDD:275380	6/22 (27%)
		LRR_8	122..182	CDD:290566	18/59 (31%)
		leucine-rich repeat	124..147	CDD:275380	8/22 (36%)
		leucine-rich repeat	148..171	CDD:275380	6/22 (27%)
		LRR_8	170..230	CDD:290566	12/59 (20%)
		leucine-rich repeat	172..195	CDD:275380	4/22 (18%)
		leucine-rich repeat	196..219	CDD:275380	6/22 (27%)
CG42709	NP_001163434.1	LRR_8	126..182	CDD:290566	17/55 (31%)
		leucine-rich repeat	128..147	CDD:275380	6/18 (33%)
		leucine-rich repeat	148..171	CDD:275380	6/22 (27%)
		LRR_RI	<150..225	CDD:238064	23/74 (31%)
		LRR_8	171..254	CDD:290566	24/90 (27%)
		leucine-rich repeat	172..195	CDD:275380	8/22 (36%)
		leucine-rich repeat	196..219	CDD:275380	6/22 (27%)
		leucine-rich repeat	220..243	CDD:275380	4/22 (18%)
		leucine-rich repeat	244..268	CDD:275380	8/41 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468852
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930