DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18480 and Toll-7

DIOPT Version :9

Sequence 1:	NP_001285960.1	Gene:	CG18480 / 34920	FlyBaseID:	FBgn0028518	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster

Alignment Length:	255	Identity:	63/255 - (24%)
Similarity:	110/255 - (43%)	Gaps:	34/255 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 DLHAQRNRAV-----------------CSAKRLISANIEIPTTVEL-----LDLSYNDITTIDDD 92
            ::|.|:|...                 .|..:|.|.:::..|...|     |:|::|.:|.||..
  Fly   324 EIHLQQNELYELPKGLFHRLEQLLVVDLSGNQLTSNHVDNTTFAGLIRLIVLNLAHNALTRIDYR 388

  Fly    93 SFKTTIHLLNLTLAHNAIHTLYGDAFVELTRLRYLDLSYNRLEQIDEHILESNNQLIHLNLEGNK 157
            :||....|..|.|.:|:|..:..:||:.|..|..|:|:.|||..:|:.:......|..|.|..|.
  Fly   389 TFKELYFLQILNLRNNSIGHIEDNAFLPLYNLHTLNLAENRLHTLDDKLFNGLYVLSKLTLNNNL 453

  Fly   158 LSTLGKGPILRSPSLRSLNLRNSQVNQLGTQLLSALPQLRQLDLAQNLLLTLSPGDFHAPRNLAS 222
            :|.:..........|:.|:|.::|:|:: .:.|..|..||.|||.:|.:.|.....|.....|..
  Fly   454 ISVVEPAVFKNCSDLKELDLSSNQLNEV-PRALQDLAMLRTLDLGENQIRTFDNQSFKNLHQLTG 517

  Fly   223 LNVEENPFNCDRALAKVATGLRQRGVAIFMSNCMEEEVQDHQDDAEAVNFPNKNEKFESM 282
            |.:      .|..:..:..|:.|....:.:.|..:..:|    ..|..:| :||.:.|::
  Fly   518 LRL------IDNQIGNITVGMFQDLPRLSVLNLAKNRIQ----SIERGSF-DKNFELEAI 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18480	NP_001285960.1	LRR_8	74..134	CDD:290566	22/64 (34%)
		LRR_RI	<76..230	CDD:238064	46/158 (29%)
		leucine-rich repeat	76..99	CDD:275380	9/27 (33%)
		leucine-rich repeat	100..123	CDD:275380	8/22 (36%)
		LRR_8	122..182	CDD:290566	15/59 (25%)
		leucine-rich repeat	124..147	CDD:275380	7/22 (32%)
		leucine-rich repeat	148..171	CDD:275380	5/22 (23%)
		LRR_8	170..230	CDD:290566	17/59 (29%)
		leucine-rich repeat	172..195	CDD:275380	7/22 (32%)
		leucine-rich repeat	196..219	CDD:275380	8/22 (36%)
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566
		leucine-rich repeat	136..159	CDD:275380
		leucine-rich repeat	160..190	CDD:275380
		LRR_8	189..259	CDD:290566
		leucine-rich repeat	191..214	CDD:275380
		leucine-rich repeat	215..248	CDD:275380
		LRR_RI	247..501	CDD:238064	49/177 (28%)
		LRR_8	247..308	CDD:290566
		leucine-rich repeat	249..273	CDD:275380
		leucine-rich repeat	274..297	CDD:275380
		LRR_8	297..356	CDD:290566	4/31 (13%)
		leucine-rich repeat	298..321	CDD:275380
		leucine-rich repeat	322..345	CDD:275380	3/20 (15%)
		LRR_8	345..406	CDD:290566	17/60 (28%)
		leucine-rich repeat	346..371	CDD:275380	5/24 (21%)
		leucine-rich repeat	372..395	CDD:275380	8/22 (36%)
		leucine-rich repeat	396..419	CDD:275380	8/22 (36%)
		LRR_8	419..478	CDD:290566	15/58 (26%)
		leucine-rich repeat	420..443	CDD:275380	7/22 (32%)
		leucine-rich repeat	444..467	CDD:275380	5/22 (23%)
		LRR_RI	466..622	CDD:238064	27/113 (24%)
		leucine-rich repeat	468..488	CDD:275380	6/20 (30%)
		LRR_8	491..549	CDD:290566	14/63 (22%)
		leucine-rich repeat	491..514	CDD:275380	8/22 (36%)
		leucine-rich repeat	515..536	CDD:275380	5/26 (19%)
		leucine-rich repeat	539..562	CDD:275380	6/27 (22%)
		leucine-rich repeat	563..585	CDD:275380	1/4 (25%)
		leucine-rich repeat	586..626	CDD:275380
		leucine-rich repeat	627..653	CDD:275380
		LRRCT	716..772	CDD:214507
		LRRNT	796..830	CDD:214470
		leucine-rich repeat	812..829	CDD:275380
		leucine-rich repeat	833..854	CDD:275380
		LRR_8	853..913	CDD:290566
		leucine-rich repeat	855..878	CDD:275380
		LRR_4	878..918	CDD:289563
		leucine-rich repeat	879..902	CDD:275380
		leucine-rich repeat	903..926	CDD:275380
		leucine-rich repeat	927..953	CDD:275380
		TIR	1098..1235	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468853
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840