DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18480 and IGFALS

DIOPT Version :9

Sequence 1:	NP_001285960.1	Gene:	CG18480 / 34920	FlyBaseID:	FBgn0028518	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	NP_001139478.1	Gene:	IGFALS / 3483	HGNCID:	5468	Length:	643	Species:	Homo sapiens

Alignment Length:	226	Identity:	61/226 - (26%)
Similarity:	94/226 - (41%)	Gaps:	32/226 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 CPTVCHC--DLHAQRNRAVCSAKRLISANIEIPTTVELLDLSYNDITTIDDDSFK--TTIHLLNL 103
            ||..|.|  |..|......||::.|......:|...:.|.|..|:::::...:|:  :::..|||
Human    79 CPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNL 143

  Fly   104 -----------------TLAH-----NAIHTLYGDAFVELTRLRYLDLSYNRLEQIDEHILESNN 146
                             .|.|     |.:.:|....|.....|..|.||.|||.::::.:.|...
Human   144 QGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLG 208

  Fly   147 QLIHLNLEGNKLSTLGKGPILRSPSLRSLNLRNSQVNQLGTQLLSALPQLRQLDLAQNLLLTLSP 211
            .|..|||..|.|:.|.........|||.|.|..:::..|...|.|.|.:||:|||::|.|..:..
Human   209 SLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKA 273

  Fly   212 GDFHAPRNLASLNVEENPFNCDRALAKVATG 242
            ..|.....|..|.::.|      .:|.||.|
Human   274 NVFVQLPRLQKLYLDRN------LIAAVAPG 298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18480	NP_001285960.1	LRR_8	74..134	CDD:290566	17/83 (20%)
		LRR_RI	<76..230	CDD:238064	47/177 (27%)
		leucine-rich repeat	76..99	CDD:275380	4/24 (17%)
		leucine-rich repeat	100..123	CDD:275380	8/44 (18%)
		LRR_8	122..182	CDD:290566	20/59 (34%)
		leucine-rich repeat	124..147	CDD:275380	8/22 (36%)
		leucine-rich repeat	148..171	CDD:275380	7/22 (32%)
		LRR_8	170..230	CDD:290566	20/59 (34%)
		leucine-rich repeat	172..195	CDD:275380	8/22 (36%)
		leucine-rich repeat	196..219	CDD:275380	8/22 (36%)
IGFALS	NP_001139478.1	LRRNT	78..116	CDD:214470	10/36 (28%)
		leucine-rich repeat	95..113	CDD:275380	4/17 (24%)
		leucine-rich repeat	114..137	CDD:275380	4/22 (18%)
		leucine-rich repeat	138..161	CDD:275380	3/22 (14%)
		LRR_8	141..196	CDD:290566	13/54 (24%)
		leucine-rich repeat	162..185	CDD:275380	5/22 (23%)
		LRR_8	184..244	CDD:290566	20/59 (34%)
		leucine-rich repeat	186..209	CDD:275380	8/22 (36%)
		leucine-rich repeat	210..233	CDD:275380	7/22 (32%)
		leucine-rich repeat	234..257	CDD:275380	8/22 (36%)
		LRR_8	257..316	CDD:290566	15/48 (31%)
		leucine-rich repeat	258..281	CDD:275380	8/22 (36%)
		leucine-rich repeat	282..305	CDD:275380	7/23 (30%)
		leucine-rich repeat	306..324	CDD:275380
		LRR_8	336..388	CDD:290566
		leucine-rich repeat	354..377	CDD:275380
		LRR_8	377..433	CDD:290566
		leucine-rich repeat	378..401	CDD:275380
		leucine-rich repeat	402..423	CDD:275380
		LRR_8	425..484	CDD:290566
		leucine-rich repeat	426..447	CDD:275380
		leucine-rich repeat	450..473	CDD:275380
		leucine-rich repeat	474..497	CDD:275380
		LRR_8	476..532	CDD:290566
		leucine-rich repeat	498..519	CDD:275380
		leucine-rich repeat	522..543	CDD:275380
		LRR_8	524..575	CDD:290566
		leucine-rich repeat	546..565	CDD:275380
		TPKR_C2	574..618	CDD:301599
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910