DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18480 and kek2

DIOPT Version :9

Sequence 1:	NP_001285960.1	Gene:	CG18480 / 34920	FlyBaseID:	FBgn0028518	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	NP_523551.1	Gene:	kek2 / 34582	FlyBaseID:	FBgn0015400	Length:	894	Species:	Drosophila melanogaster

Alignment Length:	378	Identity:	83/378 - (21%)
Similarity:	141/378 - (37%)	Gaps:	71/378 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 MWLGLKQILLYVGLLLCVLLQVCRSKTQSQMFCPTVCHCDLHAQRNRAVCSAKRLISANIEIPTT 75
            :|:.|        |.|..:...|.         |.||.|.....:....|..::|.:....:...
  Fly     6 IWIPL--------LALLAITAACP---------PEVCVCKWKGGKQTVECGGQQLSNLPEGMDPG 53

  Fly    76 VELLDLSYNDITTIDDDSFKTTIHLLNLT---LAHNAIHTLYGDAFVELTRLRYLDLSYNRLEQI 137
            .::|:.|.|.:..:..:.| ..:.||||.   |:.|.:..::..||..||.|..||||.|.|:.:
  Fly    54 TQVLNFSGNALQVLQSERF-LRMDLLNLQKIYLSRNQLIRIHEKAFRGLTNLVELDLSENALQNV 117

  Fly   138 DEHILESNNQLIHLNLEGNKLSTLGKGPILRSPSLRSLNLRNSQVNQLGTQLLSALPQLRQLDLA 202
            .....:..:.|:.|:|.||.:..|..........|.:|.|.|.||.::..:....:..|..|.|.
  Fly   118 PSETFQDYSSLMRLSLSGNPIRELKTSAFRHLSFLTTLELSNCQVERIENEAFVGMDNLEWLRLD 182

  Fly   203 QNLLLTLSPGDFHAPRNLASLNVEENPFNCDRALAKVATGLRQRGVAIFMSNCMEEEVQDHQDDA 267
            .|.:..:. |....|::|..:::..|.:|||..|..:...|
  Fly   183 GNRIGFIQ-GTHILPKSLHGISLHSNRWNCDCRLLDIHFWL------------------------ 222

  Fly   268 EAVNFPNKNEKFESMEYLEPSTRGPQSVLSVWRDLDSSEEQNSSQDDEQMSSLSDVCEGSREKLC 332
              ||:  .....|..:.:||:....|.:.|:.|:..:...:.|.|     ||.::|.||....:
  Fly   223 --VNY--NTPLAEEPKCMEPARLKGQVIKSLQREQLACLPEVSPQ-----SSYTEVSEGRNMSI- 277

  Fly   333 LRYRICLERVSHE----LLAGGNSQLEDEIIRTHTYDEDDLKLAFVVGGATGV 381
                .||.|...|    .|..|.....|.::       |:|.:.:.:....||
  Fly   278 ----TCLVRAIPEPKVLWLFNGQVMSNDSLM-------DNLHMYYYIDETIGV 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18480	NP_001285960.1	LRR_8	74..134	CDD:290566	20/62 (32%)
		LRR_RI	<76..230	CDD:238064	41/156 (26%)
		leucine-rich repeat	76..99	CDD:275380	4/22 (18%)
		leucine-rich repeat	100..123	CDD:275380	9/25 (36%)
		LRR_8	122..182	CDD:290566	18/59 (31%)
		leucine-rich repeat	124..147	CDD:275380	7/22 (32%)
		leucine-rich repeat	148..171	CDD:275380	6/22 (27%)
		LRR_8	170..230	CDD:290566	14/59 (24%)
		leucine-rich repeat	172..195	CDD:275380	6/22 (27%)
		leucine-rich repeat	196..219	CDD:275380	6/22 (27%)
kek2	NP_523551.1	leucine-rich repeat	34..52	CDD:275380	2/17 (12%)
		leucine-rich repeat	54..79	CDD:275380	5/25 (20%)
		LRR_8	79..138	CDD:290566	20/58 (34%)
		LRR_RI	<80..187	CDD:238064	30/106 (28%)
		leucine-rich repeat	80..103	CDD:275380	6/22 (27%)
		leucine-rich repeat	104..127	CDD:275380	7/22 (32%)
		LRR_8	126..186	CDD:290566	16/59 (27%)
		leucine-rich repeat	128..151	CDD:275380	6/22 (27%)
		leucine-rich repeat	152..175	CDD:275380	6/22 (27%)
		leucine-rich repeat	176..198	CDD:275380	6/22 (27%)
		TPKR_C2	207..256	CDD:301599	14/76 (18%)
		I-set	258..361	CDD:254352	18/79 (23%)
		Ig_2	263..361	CDD:290606	17/74 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24366
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010