DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG18480 and Toll-4

DIOPT Version :9

Sequence 1:NP_001285960.1 Gene:CG18480 / 34920 FlyBaseID:FBgn0028518 Length:550 Species:Drosophila melanogaster
Sequence 2:NP_523519.2 Gene:Toll-4 / 34235 FlyBaseID:FBgn0032095 Length:1125 Species:Drosophila melanogaster


Alignment Length:551 Identity:94/551 - (17%)
Similarity:165/551 - (29%) Gaps:232/551 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 CVTKPKMWLGLKQILLYVGLLLCVLLQ----------VCRSKTQ--------SQMFCPTVCHCDL 51
            |:.|....:.||....:..|.:..:.|          :|.....        :::.||..|:|..
  Fly   316 CIMKVDNMVDLKSFEKFTNLEIIEVSQYKGFKNFTAFICEPYKSHCKFTLGINEVACPLKCNCSY 380

  Fly    52 HAQRNRAV--CSAKRL-----------------ISANI--EIPT-------TVELLDLSYNDITT 88
            :..:::..  |..|.|                 ..:|:  |:|.       .::.||:|||.:|:
  Fly   381 NRDKSQLEIDCWQKNLTTIPSLPVPKKGSSALVFQSNLLAELPDNSLEGYHNLKSLDVSYNQLTS 445

  Fly    89 IDDDSFKTTIHLLNLTLAHNAIHTL----------------YGDAF----------------VEL 121
            :.......::|.|:  :.||.|.||                ||:.:                .:|
  Fly   446 LSVSQLPESLHYLD--IRHNKITTLSPQVVEYLYSVNVFNQYGNKWSIYCDEYHLQEFFWYKAKL 508

  Fly   122 TRLR---------YLDLSYNR-------LEQIDEHILESNNQ----------------------- 147
            .|::         |::||...       ::.||:..||:|..                       
  Fly   509 LRIKTSKFQTIMEYIELSSKGSFVENFFVQNIDQLYLEANEDEIIDAFGPSDKYFNLKLMEALNH 573

  Fly   148 -------------LIHLN--------------------------------------------LEG 155
                         |.|||                                            |:.
  Fly   574 AIWLFSGEFDEIILHHLNSPCPYRCSCCFEWHTGEFLINCRNLSLDIYPRLPNSIPYKTTLYLDR 638

  Fly   156 N---KLSTLGKGPILRSPSLRSLNLRNSQVNQLGTQLLSALPQ-LRQLDLAQNLLLTLSPG---- 212
            |   ||:......:....|:..|::..:.:.:|...|   ||: :..||:..|||..|..|    
  Fly   639 NEIRKLTNTESLVVAGHASIHKLHMSQNLLRELPLHL---LPENITYLDVRNNLLKYLDDGVIAF 700

  Fly   213 -DFHAPRNLASLNVEENPFNCDRALAKVATGLRQ----------RGVAIFMSNCMEE---EVQDH 263
             ::.  .|:..:.:..||:.|:.......:.||:          |.|.|....|.|:   .|...
  Fly   701 LEYR--ENITKIELSGNPWECNCKAKAFLSFLRRHEPMEYETVLRRVEITDDKCPEDCICCVDTS 763

  Fly   264 QDDAEAVNFPNKNEKFESMEYLEPSTRG--------------PQSVL----SVWR---------D 301
            ..|:.|.......::...:..|...|.|              |.|:|    ||.|         |
  Fly   764 NSDSLAYVVDCSGKELSEIPQLPTPTYGQTTLVFERNSLKKWPSSLLPGYSSVTRFYLAHNRLSD 828

  Fly   302 LDSSEEQNSSQD--DEQMSSLSDVCEGSREK 330
            :|...::....|  :...|:|.|...|..:|
  Fly   829 IDQLPDKLEYLDISNNNFSALDDRVRGFLQK 859

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG18480NP_001285960.1 LRR_8 74..134 CDD:290566 20/114 (18%)
LRR_RI <76..230 CDD:238064 48/290 (17%)
leucine-rich repeat 76..99 CDD:275380 6/22 (27%)
leucine-rich repeat 100..123 CDD:275380 9/54 (17%)
LRR_8 122..182 CDD:290566 19/158 (12%)
leucine-rich repeat 124..147 CDD:275380 8/38 (21%)
leucine-rich repeat 148..171 CDD:275380 8/69 (12%)
LRR_8 170..230 CDD:290566 15/65 (23%)
leucine-rich repeat 172..195 CDD:275380 4/22 (18%)
leucine-rich repeat 196..219 CDD:275380 7/27 (26%)
Toll-4NP_523519.2 leucine-rich repeat 264..287 CDD:275380
leucine-rich repeat 288..308 CDD:275380
leucine-rich repeat 309..334 CDD:275380 4/17 (24%)
leucine-rich repeat 335..386 CDD:275380 7/50 (14%)
leucine-rich repeat 388..408 CDD:275380 3/19 (16%)
LRR_8 412..465 CDD:290566 13/54 (24%)
leucine-rich repeat 412..432 CDD:275378 3/19 (16%)
LRR_4 432..470 CDD:289563 13/39 (33%)
leucine-rich repeat 433..454 CDD:275378 6/20 (30%)
leucine-rich repeat 455..478 CDD:275378 7/24 (29%)
leucine-rich repeat 479..490 CDD:275378 2/10 (20%)
leucine-rich repeat 632..657 CDD:275378 4/24 (17%)
leucine-rich repeat 658..679 CDD:275378 5/23 (22%)
leucine-rich repeat 680..706 CDD:275378 7/27 (26%)
leucine-rich repeat 707..719 CDD:275378 2/11 (18%)
leucine-rich repeat 771..791 CDD:275380 2/19 (11%)
leucine-rich repeat 793..815 CDD:275378 3/21 (14%)
leucine-rich repeat 816..835 CDD:275378 4/18 (22%)
leucine-rich repeat 836..859 CDD:275378 5/22 (23%)
TIR 974..1110 CDD:214587
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45468850
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.930

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