DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG18480 and LRRC15

DIOPT Version :9

Sequence 1:NP_001285960.1 Gene:CG18480 / 34920 FlyBaseID:FBgn0028518 Length:550 Species:Drosophila melanogaster
Sequence 2:NP_001128529.2 Gene:LRRC15 / 131578 HGNCID:20818 Length:587 Species:Homo sapiens


Alignment Length:594 Identity:121/594 - (20%)
Similarity:197/594 - (33%) Gaps:177/594 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    43 CPTVCHCDLHAQRNRAVCSAKRLISANIEIPTTVELLDLSYNDITTIDDDSFKTTIHLLNLTLAH 107
            ||:.|.|   ::.::..|:..|:::....:|.....|.:....||.:::..|.....|:.|.:..
Human    31 CPSECTC---SRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRIEK 92

  Fly   108 NAIHTLYGDAFVELTRLRYLDLSYNRLEQID----------EHILESNNQLI------------- 149
            |.:..:...||..|..||||.|:.|:|:.:.          |.:|.|:|||:             
Human    93 NELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNL 157

  Fly   150 -HLNLEGNKLSTLGKGPILRSPSLRSLNL-RNS---------------QVNQLGTQLLSALP--- 194
             .|.|.||.|..:..|.......|..||| :||               ||.:|....|:.:|   
Human   158 KELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGT 222

  Fly   195 -----QLRQLDLAQNLLLTLSPGDFHAPRNLASLNVEENPFNCDRALAKVATGLRQRGVAIFMSN 254
                 .|::|.|.||.:..||||.||...||..|.:..|             .:.|...::||  
Human   223 FDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNN-------------HISQLPPSVFM-- 272

  Fly   255 CMEEEVQDHQDDAEAVNFPNKNEKF---ESMEYLEPSTRGPQSVLSVWRDLDSSEEQNSSQDDEQ 316
                            ..|..|...   .|::.|.|...||...|   |:|...:...||..|..
Human   273 ----------------QLPQLNRLTLFGNSLKELSPGIFGPMPNL---RELWLYDNHISSLPDNV 318

  Fly   317 MSSLSDVCEGSREKLCLRYRICLERVSHELLA----GGNSQLEDEIIRTHTYDEDDLKLAFVVGG 377
            .|:|..:           ..:.|.|.....::    .|.::|.:..:.|:...:.|..:..::..
Human   319 FSNLRQL-----------QVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLAN 372

  Fly   378 ATGVCMV----------IFIITFALC-------------------LKSCCEMRKKKSNPEVATGV 413
            ...:.:.          ||.....|.                   |...||:|...:        
Human   373 LQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDN-------- 429

  Fly   414 SAPLNPSQDSLPTIHTWSPQRTRNPRRSNPQRPRSTQSHAVVRQPYGPQDNFVSRLFGRPA--RS 476
              |.....|.|| :..|                      .::.||....|. |...|. ||  |.
Human   430 --PWRCDSDILP-LRNW----------------------LLLNQPRLGTDT-VPVCFS-PANVRG 467

  Fly   477 QYYRTINQNTATLIRRLSRSNLFTSRDREPSSPAEPPTSTARFYTDVIESGAIRPETPPPNYGDV 541
            |....||.|.|.....:.....:......|.:|:.|.|::....|::        .:|..:|.|:
Human   468 QSLIIINVNVAVPSVHVPEVPSYPETPWYPDTPSYPDTTSVSSTTEL--------TSPVEDYTDL 524

  Fly   542 VVIENCDNK 550
            ..|:..|::
Human   525 TTIQVTDDR 533

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG18480NP_001285960.1 LRR_8 74..134 CDD:290566 16/59 (27%)
LRR_RI <76..230 CDD:238064 55/201 (27%)
leucine-rich repeat 76..99 CDD:275380 4/22 (18%)
leucine-rich repeat 100..123 CDD:275380 6/22 (27%)
LRR_8 122..182 CDD:290566 25/99 (25%)
leucine-rich repeat 124..147 CDD:275380 10/32 (31%)
leucine-rich repeat 148..171 CDD:275380 7/36 (19%)
LRR_8 170..230 CDD:290566 26/83 (31%)
leucine-rich repeat 172..195 CDD:275380 11/46 (24%)
leucine-rich repeat 196..219 CDD:275380 11/22 (50%)
LRRC15NP_001128529.2 LRR_8 60..119 CDD:290566 16/58 (28%)
LRR_RI 63..309 CDD:238064 68/279 (24%)
LRR_8 88..167 CDD:290566 22/78 (28%)
leucine-rich repeat 88..108 CDD:275380 5/19 (26%)
leucine-rich repeat 109..156 CDD:275380 13/46 (28%)
leucine-rich repeat 157..180 CDD:275380 6/22 (27%)
LRR_8 180..239 CDD:290566 16/58 (28%)
leucine-rich repeat 181..204 CDD:275380 6/22 (27%)
leucine-rich repeat 205..228 CDD:275380 5/22 (23%)
LRR_8 228..287 CDD:290566 20/89 (22%)
leucine-rich repeat 229..252 CDD:275380 11/22 (50%)
leucine-rich repeat 253..276 CDD:275380 6/53 (11%)
leucine-rich repeat 277..300 CDD:275380 6/22 (27%)
LRR_8 299..359 CDD:290566 13/73 (18%)
LRR_4 299..340 CDD:289563 10/54 (19%)
leucine-rich repeat 301..324 CDD:275380 8/25 (32%)
LRR_4 324..364 CDD:289563 5/50 (10%)
leucine-rich repeat 325..348 CDD:275380 3/33 (9%)
leucine-rich repeat 349..370 CDD:275380 3/20 (15%)
LRR_8 372..430 CDD:290566 7/67 (10%)
leucine-rich repeat 373..393 CDD:275380 2/19 (11%)
leucine-rich repeat 397..418 CDD:275380 1/20 (5%)
TPKR_C2 429..>468 CDD:301599 13/73 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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