Protein Alignment CG18480 and LRRC38

DIOPT Version :10

• Sequence 1: NP_609761.1
• Gene: CG18480 / 34920
• FlyBaseID: FBgn0028518
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: NP_001010847.1
• Gene: LRRC38 / 126755
• HGNCID: 27005
• Length: 294
• Species: Homo sapiens
• Alignment Length: 370
• Identity: 80/370 - (21%)
• Similarity: 125/370 - (33%)
• Gaps: 111/370 - (30%)

  Fly    43 CPTVCHC-DLHAQRNRAVCSAKRLISANIEIPTTVELLDLSYNDITTIDDDSFKTTIHLLNLTLA 106
            ||..|.| |.|.    ..|..:.|.|.....|..|..|.::.|.|..|.:|.|.....|:.|...
Human    28 CPAGCACTDPHT----VDCRDRGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFR 88

  Fly   107 HNAIHTLYGDAFVELTRLRYLDLSYNRLEQIDEHILESNNQLIHLNLEGNKLSTLGKGPILRSPS 171
            :|::.:|....|....:|.:||||||.|.|:......|..:|:.|:|..|.|..:.:.......|
Human    89 NNSLRSLEEGTFSGSAKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLES 153

  Fly   172 LRSLNLRNSQVNQLGTQLLSALPQLRQLDLAQNLLLTLSPGDFHAPRNLASLNVEENPFNCDRAL 236
            |:.|.|.::.:..|....|:|||.||                        ||.::.||:.||...
Human   154 LQVLELNDNNLRSLSVAALAALPALR------------------------SLRLDGNPWLCDCDF 194

  Fly   237 AKVATGLRQRGVAIFMSNCMEEEVQDHQDDAEAVNFPNKNEKFESMEYLEPSTRGPQSVLSVWRD 301
            |.:.:.:::                      .|...|                          :.
Human   195 AHLFSWIQE----------------------NASKLP--------------------------KG 211

  Fly   302 LDSSEEQNSSQDDEQMSSLSDVCEGSREKLCLRYRICLERVSHELLAGGNSQLEDEIIRTHTYDE 366
            ||  |.|.|...:.:..||.::.|.|..: | |:.:.|
Human   212 LD--EIQCSLPMESRRISLRELSEASFSE-C-RFSLSL--------------------------- 245

  Fly   367 DDLKLAFVVGGATGVCMVI---FIITFALCLKSCCEMRKKKSNPE 408
            .||.:....|.|..:..:|   |:.|...||:.|...:..:...|
Human   246 TDLCIIIFSGVAVSIAAIISSFFLATVVQCLQRCAPNKDAEDEDE 290

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18480	NP_609761.1	LRR	<66..>230	CDD:443914	43/163 (26%)
		leucine-rich repeat	76..99	CDD:275380	7/22 (32%)
		leucine-rich repeat	100..123	CDD:275380	5/22 (23%)
		leucine-rich repeat	124..147	CDD:275380	10/22 (45%)
		leucine-rich repeat	148..171	CDD:275380	5/22 (23%)
		leucine-rich repeat	172..195	CDD:275380	7/22 (32%)
		leucine-rich repeat	196..219	CDD:275380	2/22 (9%)
LRRC38	NP_001010847.1	LRRNT	27..58	CDD:214470	10/33 (30%)
		leucine-rich repeat	38..56	CDD:275380	4/21 (19%)
		LRR 1	57..78		7/20 (35%)
		LRR_8	58..116	CDD:404697	19/57 (33%)
		leucine-rich repeat	58..81	CDD:275378	7/22 (32%)
		LRR 2	81..102		5/20 (25%)
		leucine-rich repeat	82..105	CDD:275378	5/22 (23%)
		LRR 3	105..126		9/20 (45%)
		leucine-rich repeat	106..129	CDD:275378	10/22 (45%)
		LRR_8	109..164	CDD:404697	18/54 (33%)
		LRR 4	129..150		5/20 (25%)
		leucine-rich repeat	130..153	CDD:275378	5/22 (23%)
		LRR 5	153..174		6/20 (30%)
		leucine-rich repeat	154..165	CDD:275378	3/10 (30%)
		leucine-rich repeat	178..197	CDD:275380	9/42 (21%)
		LRRCT	186..237	CDD:214507	16/100 (16%)