Protein Alignment CG18480 and islr2

DIOPT Version :10

• Sequence 1: NP_609761.1
• Gene: CG18480 / 34920
• FlyBaseID: FBgn0028518
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: NP_001120371.1
• Gene: islr2 / 100145445
• XenbaseID: XB-GENE-5920691
• Length: 691
• Species: Xenopus tropicalis
• Alignment Length: 492
• Identity: 93/492 - (18%)
• Similarity: 164/492 - (33%)
• Gaps: 129/492 - (26%)

  Fly    43 CPTVCHCDLHAQRNRAVCSAKRLISANIEIPTTVELLDLSYNDITTIDDDSFKTTIHLLNLTLAH 107
            ||..|.|.....:..|.|:.|:|.......|:.|..|.||.|.||::....|.....:.:|.|||
 Frog    20 CPEPCSCVDKYNQQFADCTYKKLQKIPSGFPSNVTTLSLSANKITSLKKSDFIGVPQVTSLWLAH 84

  Fly   108 NAIHTLYGDAFVELTRLRYLDLSYNRLEQIDEHILESNNQLIHLNLEGNKLSTLGKGPILRSPSL 172
            |.|..:...|...:..|:.||:|:|.|.:.....|.|.:.|..:.:..|::..|.:........|
 Frog    85 NEISEIEEGALATMVNLKNLDVSHNLLVEFPWRDLASLSALQLIKMNNNRMVNLPRDAFQNLNEL 149

  Fly   173 RSLNLRNSQVNQLGTQLLSALPQLRQLDLAQNLLLTLSPGDFHAPRNLASLNVEENPFNCDRALA 237
            :||.:.|:|.:                        .:..|.|....:|:.:.:..|||:|..:|
 Frog   150 KSLRINNNQFS------------------------VIQEGTFKPLISLSHIQIYNNPFHCSCSL- 189

  Fly   238 KVATGLRQRGVAIFMSNCMEE-EVQDHQDDAEAVNFPNKNEKFESMEYLEPSTRGPQSVLSVWRD 301
                        :::....|| :....:.|..|.:.|.:.:.....:..:.....|...||.:.:
 Frog   190 ------------MWLKKWAEEAQFSVPEKDNIACSSPEELKGTPISKIPDLPCEAPTVQLSYYPN 242

  Fly   302 LDSSE------------------------EQNSSQDDE---------------QMSS-------- 319
            |||:|                        .:|::|:.|               |.||
 Frog   243 LDSTELYDGFTLSLQCLASGIPQPTIKWKVRNATQETEIKQPVDGQVKGSAKSQKSSSFLVFQNG 307

  Fly   320 ------LSD------VCEGSREKLCLRYRICLERVSHELLAGGNSQLEDEIIRTHTYDED--DLK 370
                  ||.      :|||:.|       :...:.|..:...|:.:...::|...|..:.  :.|
 Frog   308 TLVIPHLSKKMEGTYICEGNNE-------MGSSQASVNVSVAGSQKYPTKVIEEPTKSKSLPENK 365

  Fly   371 LAFVVGGATGVCMVIFIITFALCLKSCCEMRKKKSNPEVATGVSAPLNPSQDSLPT--IHTWSPQ 433
            ...|....||..::                     .|:.:.....||.|::....|  .....|:
 Frog   366 KPGVKTSDTGNSVI---------------------KPDKSEEKGKPLIPTEQPFMTGGNKLGVPE 409

  Fly   434 RTRNPRRSNPQRPRSTQSHAVVRQPYGPQDNFVSRLF 470
            .|.:|..|:.:...||....:....:....|.....|
 Frog   410 HTDHPSASDKKCGPSTGGQHISNHAFNESTNLKPHTF 446

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18480	NP_609761.1	LRR	<66..>230	CDD:443914	36/163 (22%)
		leucine-rich repeat	76..99	CDD:275380	8/22 (36%)
		leucine-rich repeat	100..123	CDD:275380	7/22 (32%)
		leucine-rich repeat	124..147	CDD:275380	8/22 (36%)
		leucine-rich repeat	148..171	CDD:275380	3/22 (14%)
		leucine-rich repeat	172..195	CDD:275380	5/22 (23%)
		leucine-rich repeat	196..219	CDD:275380	2/22 (9%)
islr2	NP_001120371.1	LRR	<36..>228	CDD:443914	48/228 (21%)
		leucine-rich repeat	36..52	CDD:275380	4/15 (27%)
		leucine-rich repeat	53..76	CDD:275380	8/22 (36%)
		leucine-rich repeat	77..100	CDD:275380	7/22 (32%)
		leucine-rich repeat	101..124	CDD:275380	8/22 (36%)
		leucine-rich repeat	125..148	CDD:275380	3/22 (14%)
		leucine-rich repeat	149..172	CDD:275380	7/46 (15%)
		Ig	251..332	CDD:472250	12/87 (14%)
		Ig strand B	254..258	CDD:409353	0/3 (0%)
		Ig strand C	267..271	CDD:409353	0/3 (0%)
		Ig strand E	307..311	CDD:409353	0/3 (0%)
		Ig strand F	321..326	CDD:409353	1/4 (25%)