DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18480 and LRRC70

DIOPT Version :9

Sequence 1:	NP_001285960.1	Gene:	CG18480 / 34920	FlyBaseID:	FBgn0028518	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	NP_852607.3	Gene:	LRRC70 / 100130733	HGNCID:	35155	Length:	622	Species:	Homo sapiens

Alignment Length:	575	Identity:	119/575 - (20%)
Similarity:	218/575 - (37%)	Gaps:	174/575 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 LLLCVLLQVCRSKTQSQMFCPTVCHCDLHAQRNRAVCSAKRLISANI-------EIPTTVELLDL 81
            ::.|.||.:...:.   :.|.:||.          :|:.:::...|:       ..|.:...|.|
Human    16 VVTCYLLLLLHKEI---LGCSSVCQ----------LCTGRQINCRNLGLSSIPKNFPESTVFLYL 67

  Fly    82 SYNDITTIDDDSFKTTIH-LLNLTLAHNAIHTLYGDAFVELTRLRYLDLSYNRLEQIDEHILESN 145
            :.|:|:.|::... |.:| |:.|.|.::.|..:|..|||:|..|.:|.|:.|.::::|..|.:..
Human    68 TGNNISYINESEL-TGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGL 131

  Fly   146 NQLIHLNLEGNKLSTLGKGPILRSPSLRSLNLRNSQVNQLGTQLLSALPQLRQLDLAQNLLLTLS 210
            ..|.:|.|:.|::|.:.:|......|::.|||:.:::..||:.....:..||.|||:.|.:|.:|
Human   132 LNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILRIS 196

  Fly   211 PGDFHAPRNLASL-----NVEENPFNCDRALAKVATGLRQRGVAIFMSNCMEEEVQDHQDDAEAV 270
            ...|....|||.|     |:.:.|.|.    .:|...||:..::              .:..||:
Human   197 ESGFQHLENLACLYLGSNNLTKVPSNA----FEVLKSLRRLSLS--------------HNPIEAI 243

  Fly   271 NFPNKNEKFESMEYLEPSTRGPQSVLSVWRDLDSSEEQNSSQDDEQMSSLSDVCEGSREKLCLRY 335
            . |...:...::|||.               |.:|..:|.::|.  .|.:::          |::
Human   244 Q-PFAFKGLANLEYLL---------------LKNSRIRNVTRDG--FSGINN----------LKH 280

  Fly   336 RICLERVSHELLAGGNSQLEDEIIRTHTYDEDDLKLAFVVGGAT----GVCMVIFIITF----AL 392
            .|    :||..|...||. ...:::...|.:.|......:...|    |..:.|..::|    ||
Human   281 LI----LSHNDLENLNSD-TFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTAL 340

  Fly   393 CLKSCCEMRKKKSNPEVATGVSAPLNPSQDSLP--------TIHTW--SPQRTRNPRRSNPQRPR 447
                         :|.|...:|:.::...:|.|        .:..|  |...|.|....||...|
Human   341 -------------HPRVLKPLSSLIHLQANSNPWECNCKLLGLRDWLASSAITLNIYCQNPPSMR 392

  Fly   448 S------------------TQSHAVVRQPYGPQDNFVSRLFGRPARSQYYRTINQNTATL----- 489
            .                  :::.|||:.|:                      |:..|..|
Human   393 GRALRYINITNCVTSSINVSRAWAVVKSPH----------------------IHHKTTALMMAWH 435

  Fly   490 --------IRRLSRSNLFTSRDREPSSPAEPPTSTARFYTD-----VIESGAIRP 531
                    :......|: |..:|.|:|||      .||:.:     .:|:.|:.|
Human   436 KVTTNGSPLENTETENI-TFWERIPTSPA------GRFFQENAFGNPLETTAVLP 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18480	NP_001285960.1	LRR_8	74..134	CDD:290566	20/60 (33%)
		LRR_RI	<76..230	CDD:238064	48/159 (30%)
		leucine-rich repeat	76..99	CDD:275380	6/22 (27%)
		leucine-rich repeat	100..123	CDD:275380	9/22 (41%)
		LRR_8	122..182	CDD:290566	16/59 (27%)
		leucine-rich repeat	124..147	CDD:275380	6/22 (27%)
		leucine-rich repeat	148..171	CDD:275380	6/22 (27%)
		LRR_8	170..230	CDD:290566	20/64 (31%)
		leucine-rich repeat	172..195	CDD:275380	5/22 (23%)
		leucine-rich repeat	196..219	CDD:275380	9/22 (41%)
LRRC70	NP_852607.3	LRRNT	31..62	CDD:214470	6/40 (15%)
		LRR 1	61..82		5/21 (24%)
		leucine-rich repeat	65..85	CDD:275380	6/20 (30%)
		LRR_8	85..144	CDD:290566	19/58 (33%)
		LRR 2	85..106		7/20 (35%)
		leucine-rich repeat	86..109	CDD:275380	9/22 (41%)
		LRR 3	109..130		6/20 (30%)
		leucine-rich repeat	110..133	CDD:275380	6/22 (27%)
		LRR_8	133..192	CDD:290566	18/58 (31%)
		LRR 4	133..154		6/20 (30%)
		leucine-rich repeat	134..157	CDD:275380	6/22 (27%)
		LRR 5	157..178		6/20 (30%)
		leucine-rich repeat	158..181	CDD:275380	5/22 (23%)
		LRR_RI	<159..340	CDD:238064	48/231 (21%)
		LRR 6	181..202		9/20 (45%)
		LRR_8	182..240	CDD:290566	19/75 (25%)
		leucine-rich repeat	182..205	CDD:275380	9/22 (41%)
		LRR 7	205..226		7/24 (29%)
		leucine-rich repeat	206..229	CDD:275380	7/26 (27%)
		LRR_8	228..288	CDD:290566	17/105 (16%)
		LRR 8	229..250		5/35 (14%)
		leucine-rich repeat	230..253	CDD:275380	5/37 (14%)
		LRR 9	253..274		7/37 (19%)
		leucine-rich repeat	254..277	CDD:275380	8/39 (21%)
		LRR_8	277..337	CDD:290566	13/74 (18%)
		LRR 10	277..298		7/35 (20%)
		leucine-rich repeat	278..301	CDD:275380	7/27 (26%)
		LRR 11	301..322		3/20 (15%)
		leucine-rich repeat	302..326	CDD:275380	4/23 (17%)
		LRR 12	326..347		6/33 (18%)
		leucine-rich repeat	327..348	CDD:275380	6/33 (18%)
		LRRCT	359..398	CDD:214507	8/38 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910