DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7631 and mep1a.2

DIOPT Version :9

Sequence 1:	NP_609760.1	Gene:	CG7631 / 34919	FlyBaseID:	FBgn0028945	Length:	254	Species:	Drosophila melanogaster
Sequence 2:	NP_001122199.1	Gene:	mep1a.2 / 565535	ZFINID:	ZDB-GENE-041001-208	Length:	689	Species:	Danio rerio

Alignment Length:	255	Identity:	88/255 - (34%)
Similarity:	125/255 - (49%)	Gaps:	24/255 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 FLLGTLCSGIFPAPFNTHYD---------ETDPELTAGYFQGDMDVDYARNGQLSETRRWPNATV 64
            |:|..|.:...||.:....|         |.:.:.....|:||:..|..||..:.|..|| ...:
Zfish    11 FVLLALKACALPAQYGEDADAGELREDILEINLDSQRELFEGDIAGDPRRNAIIDEKARW-QFPI 74

  Fly    65 PYRISEEFDAPHVEYIKLGMQFIEYSSCIRFVPADEDEENYLFVLPSTSGCSSKVGYQPGERTVK 129
            ||.:::..|......|...::.....||:.|.|. |.|..|: ......||.|.||        .
Zfish    75 PYILTDTLDLNAKGVILQALEMYRLKSCVDFKPY-EGESTYI-SFTKLDGCWSFVG--------D 129

  Fly   130 LKPG---SLDTGCFKLGTIQHELLHTLGFHHQQCSPNRDEFVKIVEENISEGHEKNFVKYEEDEV 191
            ||.|   |:...|.....::|||||.|||:|:|...:||::|||..:.|.||.|.||.|||:|.:
Zfish   130 LKTGQNVSIGERCDTKAIVEHELLHALGFYHEQSRSDRDDYVKIWWDQIIEGKEHNFNKYEDDFI 194

  Fly   192 GDFDQPYDYGSILHYSSLAFSINGE-ATIVALNPEGQEQMGQRLMMSDTDVKRLNTMYKC 250
            .|.:.||||.||:||..|:|:.:.: .||....|.....:||||..|..|::|||.||:|
Zfish   195 TDLNTPYDYESIMHYRPLSFNKDPDIPTITTTIPAFNNIIGQRLDFSALDLERLNRMYEC 254

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7631	NP_609760.1	Astacin	57..251	CDD:279708	74/198 (37%)
CG7631	NP_609760.1	ZnMc_astacin_like	61..248	CDD:239807	69/190 (36%)
mep1a.2	NP_001122199.1	ZnMc	26..254	CDD:294052	82/238 (34%)
		Astacin	68..256	CDD:279708	74/198 (37%)
		MAM	259..423	CDD:214533
		MAM	264..423	CDD:99706
		MATH	423..579	CDD:295307
		EGF	619..653	CDD:278437
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910