DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7631 and MEP1A

DIOPT Version :9

Sequence 1:	NP_609760.1	Gene:	CG7631 / 34919	FlyBaseID:	FBgn0028945	Length:	254	Species:	Drosophila melanogaster
Sequence 2:	XP_011512930.1	Gene:	MEP1A / 4224	HGNCID:	7015	Length:	774	Species:	Homo sapiens

Alignment Length:	249	Identity:	83/249 - (33%)
Similarity:	125/249 - (50%)	Gaps:	13/249 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 WFQLFLLGTLCSGIFPAPFNTHYDETDPELTAG--YFQGDMDVDYARNGQLSETRRWPNATVPYR 67
            :||:..|..  ..:..|.|....|.::..|.||  .||||:.:..:|||......|| ...:||.
Human    49 FFQIKYLPE--ENVHDADFGEQKDISEINLAAGLDLFQGDILLQKSRNGLRDPNTRW-TFPIPYI 110

  Fly    68 ISEEFDAPHVEYIKLGMQFIEYSSCIRFVPADEDEENYLFVLPSTSGCSSKVGYQPGERTVKLKP 132
            :::.........|....:.....||:.|.|. |.|.:|: :.....||.|:||.|...:.:
Human   111 LADNLGLNAKGAILYAFEMFRLKSCVDFKPY-EGESSYI-IFQQFDGCWSEVGDQHVGQNI---- 169

  Fly   133 GSLDTGCFKLGTIQHELLHTLGFHHQQCSPNRDEFVKIVEENISEGHEKNFVKYEEDEVGDFDQP 197
             |:..||.....|:||:||.|||:|:|...:||::|.|..:.|..|::.||..|::..:.|.:.|
Human   170 -SIGQGCAYKAIIEHEILHALGFYHEQSRTDRDDYVNIWWDQILSGYQHNFDTYDDSLITDLNTP 233

  Fly   198 YDYGSILHYSSLAFSINGEA-TIVALNPEGQEQMGQRLMMSDTDVKRLNTMYKC 250
            |||.|::||...:|:.|... ||.|..||....:||||..|..|::|||.||.|
Human   234 YDYESLMHYQPFSFNKNASVPTITAKIPEFNSIIGQRLDFSAIDLERLNRMYNC 287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7631	NP_609760.1	Astacin	57..251	CDD:279708	67/195 (34%)
CG7631	NP_609760.1	ZnMc_astacin_like	61..248	CDD:239807	62/187 (33%)
MEP1A	XP_011512930.1	ZnMc_meprin	58..287	CDD:239809	79/236 (33%)
		Astacin	101..289	CDD:279708	67/195 (34%)
		MAM	292..459	CDD:214533
		MAM	297..459	CDD:99706
		MATH_Meprin_Alpha	459..622	CDD:239752
		EGF_CA	700..738	CDD:238011
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910