DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7631 and Nrx-IV

DIOPT Version :9

Sequence 1:	NP_609760.1	Gene:	CG7631 / 34919	FlyBaseID:	FBgn0028945	Length:	254	Species:	Drosophila melanogaster
Sequence 2:	NP_524034.2	Gene:	Nrx-IV / 39387	FlyBaseID:	FBgn0013997	Length:	1284	Species:	Drosophila melanogaster

Alignment Length:	318	Identity:	61/318 - (19%)
Similarity:	106/318 - (33%)	Gaps:	113/318 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIRVWFQLFLLGTLCSGIFPAPFNTHYDETDPELTAGY---------FQGDMD---VDY------ 47
            |:|   ::..:|.:.:..|...:...|.: |.|....|         |:|:.|   :.|
  Fly    99 MVR---KIATMGRMHTDEFVTEYIVQYSD-DGEFWRSYVNPTSEPQMFKGNSDGNSIHYNVFEVP 159

  Fly    48 --ARNGQLSETRRWPNATVPYRISEEFDAPHVEYIKLGMQF-----IEYSSCIRFVPADEDEENY 105
              |:..:::.| ||.:     |||...:....:||...:.|     :.|.  :|..|....:|:.
  Fly   160 IIAQWVRINPT-RWHD-----RISMRVELYGCDYISENLYFNGTGLVRYD--LRREPITSTKESI 216

  Fly   106 LFVLPSTSGCSSKVGYQPGER----TVKLKPG----SLDTGCFKLGTIQ-HELLHTLGFHHQQCS 161
            .|.. .|:..:..:.|..|.:    .::||..    :||.|...:.::. ..||....:|....|
  Fly   217 RFRF-KTAFANGVMMYSRGTQGDYYALQLKDNKMVLNLDLGSRVMTSLSVGSLLDDNVWHDVVIS 280

  Fly   162 PNRDEFVKIVEENISEGHEKNFVKYEEDEVGDFDQPYDYGSILHYSSLAFSINGEATIVALN--- 223
            .|:.:.:..|:..|..|.                                 |.||.|.:.||
  Fly   281 RNQRDIIFSVDRVIVRGR---------------------------------IQGEFTRLNLNREL 312

  Fly   224 -----PEGQEQM-------------------GQRLMMSDTDV------KRLNTMYKCP 251
                 |..||.:                   ..|:|...|::      .|:||:|.||
  Fly   313 YLGGVPNVQEGLIVQQNFSGCLENIYFNSTNFIRVMKDSTELGEGYLFTRVNTIYACP 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7631	NP_609760.1	Astacin	57..251	CDD:279708	45/240 (19%)
CG7631	NP_609760.1	ZnMc_astacin_like	61..248	CDD:239807	42/233 (18%)
Nrx-IV	NP_524034.2	FA58C	46..185	CDD:214572	19/95 (20%)
		FA58C	57..184	CDD:238014	19/94 (20%)
		LamG	192..340	CDD:238058	31/183 (17%)
		LamG	376..514	CDD:238058
		EGF	546..575	CDD:278437
		Laminin_G_2	824..943	CDD:280389
		EGF_CA	966..998	CDD:238011
		Laminin_G_2	1032..1156	CDD:280389
		4.1m	1239..1255	CDD:128590
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444917
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930