DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7631 and Astl

DIOPT Version :9

Sequence 1:	NP_609760.1	Gene:	CG7631 / 34919	FlyBaseID:	FBgn0028945	Length:	254	Species:	Drosophila melanogaster
Sequence 2:	NP_001277932.1	Gene:	Astl / 215095	MGIID:	3046414	Length:	435	Species:	Mus musculus

Alignment Length:	290	Identity:	84/290 - (28%)
Similarity:	123/290 - (42%)	Gaps:	62/290 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 WF--QLFLLG--------TLCSGI----FPAPFNTHYDETDPELTAGYFQGDMDVDYARNGQLSE 55
            |.  .|.|||        :.|||:    .|..|.       || .:..|| |.|:.....|.:||
Mouse    10 WILTMLSLLGLSMGAPSASRCSGVCSTSVPEGFT-------PE-GSPVFQ-DKDIPAINQGLISE 65

  Fly    56 -------------------------TRRWPNAT-----VPYRISEEFDAPHVEYIKLGMQFIEYS 90
                                     ..:||...     :|:.:|.::|......|.......|..
Mouse    66 ETPESSFLVEGDIIRPSPFRLLSVTNNKWPKGVGGFVEIPFLLSRKYDELSRRVIMDAFAEFERF 130

  Fly    91 SCIRFVPADEDEENYLFVLPSTSGCSSKVGYQPGERTVKLKPGSLDTGCFKLGTIQHELLHTLGF 155
            :||||| |...:.:::.:|| .:||.|.||...|.:.|.|.|..|..|   .|.:.|||:|.|||
Mouse   131 TCIRFV-AYHGQRDFVSILP-MAGCFSGVGRSGGMQVVSLAPTCLRKG---RGIVLHELMHVLGF 190

  Fly   156 HHQQCSPNRDEFVKIVEENISEGHEKNFVKYEEDEVGDFDQPYDYGSILHYSSLAFSINGEATIV 220
            .|:....:||.::::....|..|.|.||:|....   :...||||.|::||...|||..|:.||:
Mouse   191 WHEHSRADRDRYIQVNWNEILPGFEINFIKSRST---NMLVPYDYSSVMHYGRFAFSWRGQPTII 252

  Fly   221 ALNPEGQEQMGQRLMMSDTDVKRLNTMYKC 250
            .| ......:|||..:|.:|:.|:..:|.|
Mouse   253 PL-WTSSVHIGQRWNLSTSDITRVCRLYNC 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7631	NP_609760.1	Astacin	57..251	CDD:279708	65/199 (33%)
CG7631	NP_609760.1	ZnMc_astacin_like	61..248	CDD:239807	61/191 (32%)
Astl	NP_001277932.1	Astacin	92..282	CDD:279708	65/199 (33%)
		ZnMc	100..281	CDD:294052	62/189 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	318..356
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000240
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910