DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11865 and MEP1A

DIOPT Version :9

Sequence 1:	NP_609759.1	Gene:	CG11865 / 34917	FlyBaseID:	FBgn0028947	Length:	240	Species:	Drosophila melanogaster
Sequence 2:	XP_011512930.1	Gene:	MEP1A / 4224	HGNCID:	7015	Length:	774	Species:	Homo sapiens

Alignment Length:	158	Identity:	64/158 - (40%)
Similarity:	92/158 - (58%)	Gaps:	10/158 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 KTCVKFRRTEYKREPQVVIQKEGSGCWSYVG--YLGRADQTLNLGSGCMSNRTIQHELLHALGFF 149
            |:||.|:  .|:.|...:|.::..||||.||  ::|   |.:::|.||.....|:||:||||||:
Human   133 KSCVDFK--PYEGESSYIIFQQFDGCWSEVGDQHVG---QNISIGQGCAYKAIIEHEILHALGFY 192

  Fly   150 HTHSDPQRDKYVRIQTDNIRSGHEHNFQRLRANGVTNYGFGYDYDSIMHYGPFAFSKNGQSTIVP 214
            |..|...||.||.|..|.|.||::|||.....:.:|:....|||:|:|||.||:|:||.....:.
Human   193 HEQSRTDRDDYVNIWWDQILSGYQHNFDTYDDSLITDLNTPYDYESLMHYQPFSFNKNASVPTIT 257

  Fly   215 LK---SHAKIGQATQMSPKDVQTLKRMY 239
            .|   .::.|||....|..|::.|.|||
Human   258 AKIPEFNSIIGQRLDFSAIDLERLNRMY 285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11865	NP_609759.1	Astacin	56..239	CDD:279708	62/156 (40%)
CG11865	NP_609759.1	ZnMc_astacin_like	58..239	CDD:239807	62/156 (40%)
MEP1A	XP_011512930.1	ZnMc_meprin	58..287	CDD:239809	64/158 (41%)
		Astacin	101..289	CDD:279708	64/158 (41%)
		MAM	292..459	CDD:214533
		MAM	297..459	CDD:99706
		MATH_Meprin_Alpha	459..622	CDD:239752
		EGF_CA	700..738	CDD:238011
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6774
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.860