DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11865 and nas-27

DIOPT Version :9

Sequence 1:	NP_609759.1	Gene:	CG11865 / 34917	FlyBaseID:	FBgn0028947	Length:	240	Species:	Drosophila melanogaster
Sequence 2:	NP_493926.2	Gene:	nas-27 / 188809	WormBaseID:	WBGene00003545	Length:	428	Species:	Caenorhabditis elegans

Alignment Length:	247	Identity:	70/247 - (28%)
Similarity:	111/247 - (44%)	Gaps:	20/247 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VIFGLGSSANGRPSIK-LQEDDIILISEQLQY-FEGNLEGRVVKS--------WSEYYWKGRTLV 62
            :|..|.:...||.::: ..|.||..:....|| ::|::  .||||        .....|| ..:.
Worm    11 LITSLHAIPRGRRAVRNRNEGDINSLVGVGQYLYQGDI--AVVKSRARRAVIRQKHKKWK-LPMP 72

  Fly    63 YSYAGGFSSLDIASIESAMAEISSKTCVKFRRTEYKREPQVVIQKEGSGCWSYVG-YLGRADQTL 126
            ||:...|.|.....:..||...|.||||.|....|. .|.|.| .||:||||:|| .....:|:|
Worm    73 YSFDRNFPSRSRQRVLEAMQFWSEKTCVTFHENRYV-YPHVSI-FEGNGCWSFVGKQPSLREQSL 135

  Fly   127 NLGSGCMSNR-TIQHELLHALGFFHTHSDPQRDKYVRIQTDNIRSGHEHNFQRLRANGVTNYGFG 190
            :|...|..:. .:.||:.|.|||:|.|:...||:::.|...|:.......|.:.....:.:....
Worm   136 SLERSCTDHTFVVAHEIAHTLGFYHEHARGDRDQFISIDYSNVNPNLTFAFAKESEKQLDHQEAA 200

  Fly   191 YDYDSIMHYGPFAFSKNGQSTIV---PLKSHAKIGQATQMSPKDVQTLKRMY 239
            |:|.|:|||....|:.|....::   ..|....:|...:.:.:||..:..:|
Worm   201 YEYGSVMHYSVDQFAVNTNRPVIYARDQKFAQAMGNRMRATFQDVSRMNVLY 252

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11865	NP_609759.1	Astacin	56..239	CDD:279708	55/187 (29%)
CG11865	NP_609759.1	ZnMc_astacin_like	58..239	CDD:239807	53/185 (29%)
nas-27	NP_493926.2	Astacin	65..254	CDD:279708	56/191 (29%)
		ZnMc_astacin_like	70..252	CDD:239807	53/183 (29%)
		CUB	334..410	CDD:294042
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D681837at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920