DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11865 and nas-8

DIOPT Version :9

Sequence 1:	NP_609759.1	Gene:	CG11865 / 34917	FlyBaseID:	FBgn0028947	Length:	240	Species:	Drosophila melanogaster
Sequence 2:	NP_501114.2	Gene:	nas-8 / 183207	WormBaseID:	WBGene00003527	Length:	403	Species:	Caenorhabditis elegans

Alignment Length:	251	Identity:	76/251 - (30%)
Similarity:	115/251 - (45%)	Gaps:	42/251 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 NGRPSIKLQEDDI---ILISEQLQYFEGNLEGRVVKSW------SEYY-----------WKGRTL 61
            ||.   ||.||.:   .::.:|: |.:|::.|:.  :|      ||..           |....:
Worm    68 NGE---KLGEDHVPAGSILWKQV-YKKGDIRGKA--AWKLDPKNSESLRRNGVITGTRKWPNGRI 126

  Fly    62 VYSYAGGFSSLDIASIESAMAEISSKTCVKFRRTEYKREPQVVIQKEG------SGCWSYVGYLG 120
            .|..:..::..:.|.:..:......||||:|       .|:..:..:.      .||:|.||..|
Worm   127 PYVISNQYNDRERAVLARSFQAYHDKTCVRF-------VPRTAVDNDYLYIGKIDGCYSDVGRAG 184

  Fly   121 RADQTLNLGSGCMSNRTIQHELLHALGFFHTHSDPQRDKYVRIQTDNIRSGHEHNFQRLRANGVT 185
             ..|.|:|.:||:...|..|||:|::||:|.|....||:::.|...||.......|.::.....:
Worm   185 -GRQELSLDNGCLQYDTAIHELMHSVGFYHEHERWDRDEHITILWHNIDREAYDQFGKVDLAESS 248

  Fly   186 NYGFGYDYDSIMHYGPFAFSKNGQSTIVPLKSH--AKIGQATQMSPKDVQTLKRMY 239
            .||..|||.|||||...||||||..|:|..:|.  |.||.|...||.|:..:..||
Worm   249 YYGQLYDYYSIMHYDSLAFSKNGFETMVAKQSEMTAVIGAAIDFSPIDILKMNLMY 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11865	NP_609759.1	Astacin	56..239	CDD:279708	61/190 (32%)
CG11865	NP_609759.1	ZnMc_astacin_like	58..239	CDD:239807	60/188 (32%)
nas-8	NP_501114.2	Astacin	119..308	CDD:279708	63/194 (32%)
		ZnMc_astacin_like	123..304	CDD:239807	60/188 (32%)
		ShK	337..372	CDD:279838
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D472790at33208
OrthoFinder	1	1.000	-	-		FOG0000240
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920