DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11865 and nas-7

DIOPT Version :9

Sequence 1:	NP_609759.1	Gene:	CG11865 / 34917	FlyBaseID:	FBgn0028947	Length:	240	Species:	Drosophila melanogaster
Sequence 2:	NP_495552.2	Gene:	nas-7 / 182368	WormBaseID:	WBGene00003526	Length:	382	Species:	Caenorhabditis elegans

Alignment Length:	253	Identity:	76/253 - (30%)
Similarity:	119/253 - (47%)	Gaps:	40/253 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 KLQEDDIILISE-----QLQYFE-------GNLEGRVVK----------------------SWSE 53
            ::|:|::::||:     .|:.||       ..|.|:.:.                      |.:.
Worm    22 RVQDDEMLVISDSTDSLNLEDFEFADKLTREELFGKHIPVEVVNDFKSDIRLPRRHKRNGVSRAA 86

  Fly    54 YYWKGRTLVYSYAGGFSSLDIASIESAMAEISSKTCVKF--RRTEYKREPQVVIQKEGSGCWSYV 116
            ..|....:.|:.:..:|..:.|.:..|:.:...|||::|  |:|   .||..:...:..||:|.|
Worm    87 KLWPNARIPYAISPHYSPHERALLAKAVKQYHEKTCIRFVPRQT---GEPDYLFIGKVDGCFSEV 148

  Fly   117 GYLGRADQTLNLGSGCMSNRTIQHELLHALGFFHTHSDPQRDKYVRIQTDNIRSGHEHNFQRLRA 181
            |..... |.|:|.:|||...||.||::|.:||:|.|....||.::.|...||..|....|.::..
Worm   149 GRTSGV-QVLSLDNGCMEYATIIHEMMHVVGFYHEHERWDRDNFIDIIWQNIDRGALDQFGKVDL 212

  Fly   182 NGVTNYGFGYDYDSIMHYGPFAFSKNGQSTIVPLKSHAKIGQATQMSPKDVQTLKRMY 239
            :..:.||..|||.||:||...||||||..|::|....|.||.|...|..|:..:.|||
Worm   213 SKTSYYGQPYDYKSILHYDSLAFSKNGFPTMLPKVKSATIGNARDFSDVDISKINRMY 270

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11865	NP_609759.1	Astacin	56..239	CDD:279708	64/184 (35%)
CG11865	NP_609759.1	ZnMc_astacin_like	58..239	CDD:239807	63/182 (35%)
nas-7	NP_495552.2	Astacin	87..274	CDD:279708	66/188 (35%)
		ZnMc_astacin_like	91..270	CDD:239807	63/182 (35%)
		ShK	347..382	CDD:279838
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6774
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D472790at33208
OrthoFinder	1	1.000	-	-		FOG0000240
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.870