DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11865 and hch-1

DIOPT Version :9

Sequence 1:	NP_609759.1	Gene:	CG11865 / 34917	FlyBaseID:	FBgn0028947	Length:	240	Species:	Drosophila melanogaster
Sequence 2:	NP_510440.1	Gene:	hch-1 / 181564	WormBaseID:	WBGene00001828	Length:	605	Species:	Caenorhabditis elegans

Alignment Length:	247	Identity:	74/247 - (29%)
Similarity:	117/247 - (47%)	Gaps:	38/247 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 LQEDDIILISEQLQYFEGNLEGRVVKSWSEYYW-------------KGRTLVYS----------- 64
            |.|.|::|..||:..        ::|:..:.||             :|:..:.|
Worm    83 LFEGDMVLTDEQMDL--------IIKNVRDQYWARKSSTNEFLYAIRGKRSMTSFLSERWSFPVP 139

  Fly    65 -YAGGFSSLDIASIESAMAEISSKTCVKFRR-TEYKREPQVVIQK--EGSGCWSYVGYLGRADQT 125
             |....|.::..::.:.:|:...:||.:|.| ..|....:....:  .|:||:|.:|.:.|..|.
Worm   140 YYIDTSSGVNTNAVLAGVAKWEQETCARFTRLNSYSSSSRQNALRFISGNGCYSNIGKVSRFPQD 204

  Fly   126 LNLGSGCMSNRTIQHELLHALGFFHTHSDPQRDKYVRIQTDNIRSGHEHNFQRLRANGVTNYGFG 190
            :::|.||.|..|:.||:.|||||:|..:...||.||.|.|.||:..:...|.:..|:.:.:||.|
Worm   205 VSIGWGCTSLGTVCHEIGHALGFYHEQARYDRDDYVSILTQNIQDMYLSQFTKQSASSMVDYGVG 269

  Fly   191 YDYDSIMHYGPFAFSKNGQSTIVPLKSH--AKIGQATQMSPKDVQTLKRMYC 240
            |||.|:|||...|||..|.:||.....:  |.|||....|..||:.:...||
Worm   270 YDYGSVMHYDQAAFSSTGGNTIATRDPNFQATIGQRVAPSFADVKRINFAYC 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11865	NP_609759.1	Astacin	56..239	CDD:279708	64/212 (30%)
CG11865	NP_609759.1	ZnMc_astacin_like	58..239	CDD:239807	63/197 (32%)
hch-1	NP_510440.1	Astacin	132..323	CDD:279708	63/190 (33%)
		ZnMc_astacin_like	135..320	CDD:239807	61/184 (33%)
		CUB	386..466	CDD:214483
		TSP1	533..565	CDD:214559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910