Protein Alignment CG15253 and TLL2

DIOPT Version :10

• Sequence 1: NP_609758.1
• Gene: CG15253 / 34916
• FlyBaseID: FBgn0028948
• Length: 253
• Species: Drosophila melanogaster
• Sequence 2: NP_036597.1
• Gene: TLL2 / 7093
• HGNCID: 11844
• Length: 1015
• Species: Homo sapiens
• Alignment Length: 215
• Identity: 74/215 - (34%)
• Similarity: 105/215 - (48%)
• Gaps: 12/215 - (5%)

  Fly    46 SRNIWRNETYR----WPNRIIYYHINSYIDEEHRNHIVSAIQKIESISCLTFKEATTDQKYYVNV 106
            |..:.|..|.|    ||..:|.|.|........|.....|::..|..:|:||.| .||::.::..
Human   144 SPRVRRATTSRTERIWPGGVIPYVIGGNFTGSQRAIFKQAMRHWEKHTCVTFIE-RTDEESFIVF 207

  Fly   107 TSEEGGCFSYIGYLNRVQQLNLQNNEIGVGCFRLYTIVHEFLHALGFFHQQSAADRDDYVQIVEE 171
            :....||.||:|....    ..|...||..|.:...:.||..|.:||:|:.:..|||.:|.|:.|
Human   208 SYRTCGCCSYVGRRGG----GPQAISIGKNCDKFGIVAHELGHVVGFWHEHTRPDRDQHVTIIRE 268

  Fly   172 NITEGMEFNFDKYTEETVNDFGEKYDYGSVMHYGPYAFSKN-GERTILALEE--GKEDVIGQRLE 233
            ||..|.|:||.|.....|:..||.||:.|:|||....||:. ...|||..::  |....||||:.
Human   269 NIQPGQEYNFLKMEAGEVSSLGETYDFDSIMHYARNTFSRGVFLDTILPRQDDNGVRPTIGQRVR 333

  Fly   234 LSETDIRKLNAIYKCPTVKE 253
            ||:.||.:...:||||...|
Human   334 LSQGDIAQARKLYKCPACGE 353

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG15253	NP_609758.1	ZnMc_astacin_like	59..246	CDD:239807	63/189 (33%)
TLL2	NP_036597.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	24..49
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	88..130
		ZnMc_BMP1_TLD	150..349	CDD:239808	69/203 (34%)
		CUB	351..460	CDD:395345	1/3 (33%)
		CUB	464..573	CDD:395345
		FXa_inhibition	580..616	CDD:464251
		CUB	620..729	CDD:395345
		FXa_inhibition	736..771	CDD:464251
		CUB	776..885	CDD:395345
		CUB	889..1002	CDD:395345