DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15253 and TLL1

DIOPT Version :9

Sequence 1:	NP_609758.1	Gene:	CG15253 / 34916	FlyBaseID:	FBgn0028948	Length:	253	Species:	Drosophila melanogaster
Sequence 2:	NP_036596.3	Gene:	TLL1 / 7092	HGNCID:	11843	Length:	1013	Species:	Homo sapiens

Alignment Length:	226	Identity:	79/226 - (34%)
Similarity:	115/226 - (50%)	Gaps:	16/226 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 AGYIEGDMVPSGSSRNIWRNETYR-WPNRIIYYHINSYIDEEHRNHIVSAIQKIESISCLTFKEA 96
            :|..|.:.||..::     :.|.| ||..:|.|.|........|.....|::..|..:|:||.|
Human   137 SGQNEKNRVPRAAT-----SRTERIWPGGVIPYVIGGNFTGSQRAMFKQAMRHWEKHTCVTFIE- 195

  Fly    97 TTDQKYYVNVTSEEGGCFSYIGYL-NRVQQLNLQNNEIGVGCFRLYTIVHEFLHALGFFHQQSAA 160
            .:|::.|:..|....||.||:|.. |..|.::     ||..|.:...:|||..|.:||:|:.:..
Human   196 RSDEESYIVFTYRPCGCCSYVGRRGNGPQAIS-----IGKNCDKFGIVVHELGHVIGFWHEHTRP 255

  Fly   161 DRDDYVQIVEENITEGMEFNFDKYTEETVNDFGEKYDYGSVMHYGPYAFSKN-GERTILAL--EE 222
            |||::|.|:.|||..|.|:||.|.....||..||:||:.|:|||....||:. ...|||..  :.
Human   256 DRDNHVTIIRENIQPGQEYNFLKMEPGEVNSLGERYDFDSIMHYARNTFSRGMFLDTILPSRDDN 320

  Fly   223 GKEDVIGQRLELSETDIRKLNAIYKCPTVKE 253
            |....||||..||:.||.:...:|:||...|
Human   321 GIRPAIGQRTRLSKGDIAQARKLYRCPACGE 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15253	NP_609758.1	Astacin	55..250	CDD:279708	72/199 (36%)
CG15253	NP_609758.1	ZnMc_astacin_like	59..246	CDD:239807	67/190 (35%)
TLL1	NP_036596.3	ZnMc_BMP1_TLD	148..347	CDD:239808	72/209 (34%)
		Astacin	155..348	CDD:279708	72/198 (36%)
		CUB	349..458	CDD:278839	1/3 (33%)
		CUB	462..571	CDD:278839
		FXa_inhibition	582..614	CDD:291342
		CUB	618..727	CDD:278839
		FXa_inhibition	734..769	CDD:291342
		CUB	774..883	CDD:278839
		CUB	887..1000	CDD:278839
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810