DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15253 and Astl

DIOPT Version :9

Sequence 1:	NP_609758.1	Gene:	CG15253 / 34916	FlyBaseID:	FBgn0028948	Length:	253	Species:	Drosophila melanogaster
Sequence 2:	NP_001099974.1	Gene:	Astl / 296129	RGDID:	1562279	Length:	436	Species:	Rattus norvegicus

Alignment Length:	291	Identity:	87/291 - (29%)
Similarity:	133/291 - (45%)	Gaps:	58/291 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLLLLVVVNVAWAAPSI--------------------RIETD---PELTAGYI-----------E 37
            :|.||.:..:...|||.                    |:..|   |.:..|.|           |
  Rat    11 MLTLLSLTGLILGAPSASRCSGVCSTSVPEGFTPEGSRVSQDKDIPAINQGLISEETPESSFLVE 75

  Fly    38 GDMVPSGSSR--NIWRNETYRWPNRI-----IYYHINSYIDEEHRNHIVSAIQKIESISCLTFKE 95
            ||::.....|  ::..|   :||..:     |.:.::|..||..|..|:.|..:.|..:|:.| .
  Rat    76 GDIIRPSPFRLLSVTNN---KWPKGVDGIVEIPFLLSSKYDEPSRQVIMEAFAEFERFTCIRF-V 136

  Fly    96 ATTDQKYYVNVTSEEGGCFSYIGYLNRVQQLNLQNN--EIGVGCFRLYTIVHEFLHALGFFHQQS 158
            |...|:.:|::. ...||||.:|....:|.::|...  :.|.|     .::||.:|.|||:|:.|
  Rat   137 AYRGQRDFVSIL-PMAGCFSGVGRSGGMQVVSLAPTCLQKGRG-----IVLHELMHVLGFWHEHS 195

  Fly   159 AADRDDYVQIVEENITEGMEFNFDKYTEETVNDFGEKYDYGSVMHYGPYAFSKNGERTILALEEG 223
            .||||.|:::....|..|.|.||.|...   ::....|||.||||||.:|||..|:.||:.|...
  Rat   196 RADRDRYIRVNWNEILPGFEINFIKSRN---SNMLAPYDYSSVMHYGRFAFSWRGQPTIIPLWTS 257

  Fly   224 KEDVIGQRLELSETDIRKLNAIYKC-PTVKE 253
            ... ||||..||.:||.::..:|.| |:|.:
  Rat   258 SVH-IGQRWNLSTSDITRVCRLYSCSPSVPD 287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15253	NP_609758.1	Astacin	55..250	CDD:279708	69/202 (34%)
CG15253	NP_609758.1	ZnMc_astacin_like	59..246	CDD:239807	65/193 (34%)
Astl	NP_001099974.1	Astacin	92..283	CDD:279708	70/204 (34%)
		ZnMc	99..281	CDD:294052	66/192 (34%)
		ImpA_N	<305..420	CDD:303075
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D472790at33208
OrthoFinder	1	1.000	-	-		FOG0000240
OrthoInspector	1	1.000	-	-		otm46226
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.920