DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15253 and nas-13

DIOPT Version :9

Sequence 1:	NP_609758.1	Gene:	CG15253 / 34916	FlyBaseID:	FBgn0028948	Length:	253	Species:	Drosophila melanogaster
Sequence 2:	NP_510549.3	Gene:	nas-13 / 185492	WormBaseID:	WBGene00003532	Length:	450	Species:	Caenorhabditis elegans

Alignment Length:	234	Identity:	93/234 - (39%)
Similarity:	133/234 - (56%)	Gaps:	28/234 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 EGDMVPSG-SSRNI---------------WRN---ETY-RWPNRIIYYHINSYIDEEHRNHIVSA 81
            |||:..|| :||:|               .||   :|| :|....|.|.|:|......|:.|..|
Worm    79 EGDIANSGLNSRSINTFFGDSPLFGIFGVQRNAVRQTYLKWEQARIPYTISSQYSSYSRSKIAEA 143

  Fly    82 IQKIESISCLTFKEATTDQKYYVNVTSEEGGCFSYIGYLNRVQQLNLQNNEIGVGCFRLYTIVHE 146
            |::....:|:.|...:.....|:::..:: ||:|.:|.:...|.::|     |.||.:...|:||
Worm   144 IEEYRKKTCIDFSPKSAGDLDYIHIVPDD-GCYSLVGRIGGKQPVSL-----GDGCIQKGIIIHE 202

  Fly   147 FLHALGFFHQQSAADRDDYVQIVEENITEGMEFNFDKYTEETVNDFGEKYDYGSVMHYGPYAFSK 211
            .:||:||||:||.||||:||:|...|:..|::..||||:...::..|.||||||||||.|.||||
Worm   203 LMHAVGFFHEQSRADRDEYVKINWSNVEAGLQDQFDKYSLNMIDHLGTKYDYGSVMHYAPTAFSK 267

  Fly   212 NGERTILALEEGKEDVIGQRLELSETDIRKLNAIYKCPT 250
            ||:.||..:|:..|  ||||...||.||.|:|.:|.|||
Worm   268 NGKPTIEPIEKNVE--IGQRAGFSENDIYKINMLYNCPT 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15253	NP_609758.1	Astacin	55..250	CDD:279708	80/195 (41%)
CG15253	NP_609758.1	ZnMc_astacin_like	59..246	CDD:239807	76/186 (41%)
nas-13	NP_510549.3	Astacin	118..304	CDD:279708	79/193 (41%)
		ZnMc_astacin_like	122..300	CDD:239807	76/185 (41%)
		ShK	367..404	CDD:279838
		ShK	414..450	CDD:279838
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6346
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D472790at33208
OrthoFinder	1	1.000	-	-		FOG0000240
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.870