DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15253 and nas-7

DIOPT Version :9

Sequence 1:	NP_609758.1	Gene:	CG15253 / 34916	FlyBaseID:	FBgn0028948	Length:	253	Species:	Drosophila melanogaster
Sequence 2:	NP_495552.2	Gene:	nas-7 / 182368	WormBaseID:	WBGene00003526	Length:	382	Species:	Caenorhabditis elegans

Alignment Length:	260	Identity:	80/260 - (30%)
Similarity:	125/260 - (48%)	Gaps:	28/260 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLVVVNVAWAAPSIRIE--------TDPELTAGYIEGDMV---------PSGSSRNIWRNETYRW 57
            :||:.:   :..|:.:|        |..||...:|..::|         |....||........|
Worm    28 MLVISD---STDSLNLEDFEFADKLTREELFGKHIPVEVVNDFKSDIRLPRRHKRNGVSRAAKLW 89

  Fly    58 PNRIIYYHINSYIDEEHRNHIVSAIQKIESISCLTFKEATTDQKYYVNVTSEEGGCFSYIGYLNR 122
            ||..|.|.|:.:.....|..:..|:::....:|:.|....|.:..|:.: .:..||||.:|..:.
Worm    90 PNARIPYAISPHYSPHERALLAKAVKQYHEKTCIRFVPRQTGEPDYLFI-GKVDGCFSEVGRTSG 153

  Fly   123 VQQLNLQNNEIGVGCFRLYTIVHEFLHALGFFHQQSAADRDDYVQIVEENITEGMEFNFDKYTEE 187
            ||.|:|.|     ||....||:||.:|.:||:|:....|||:::.|:.:||..|....|.|....
Worm   154 VQVLSLDN-----GCMEYATIIHEMMHVVGFYHEHERWDRDNFIDIIWQNIDRGALDQFGKVDLS 213

  Fly   188 TVNDFGEKYDYGSVMHYGPYAFSKNGERTILALEEGKEDVIGQRLELSETDIRKLNAIYKCPTVK 252
            ..:.:|:.|||.|::||...||||||..|:  |.:.|...||...:.|:.||.|:|.:|.||..|
Worm   214 KTSYYGQPYDYKSILHYDSLAFSKNGFPTM--LPKVKSATIGNARDFSDVDISKINRMYNCPVEK 276

Fly 253 252
Worm 277 276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15253	NP_609758.1	Astacin	55..250	CDD:279708	66/194 (34%)
CG15253	NP_609758.1	ZnMc_astacin_like	59..246	CDD:239807	62/186 (33%)
nas-7	NP_495552.2	Astacin	87..274	CDD:279708	66/194 (34%)
		ZnMc_astacin_like	91..270	CDD:239807	62/186 (33%)
		ShK	347..382	CDD:279838
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D472790at33208
OrthoFinder	1	1.000	-	-		FOG0000240
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920