DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15253 and Mep1b

DIOPT Version :9

Sequence 1:	NP_609758.1	Gene:	CG15253 / 34916	FlyBaseID:	FBgn0028948	Length:	253	Species:	Drosophila melanogaster
Sequence 2:	NP_032612.2	Gene:	Mep1b / 17288	MGIID:	96964	Length:	704	Species:	Mus musculus

Alignment Length:	212	Identity:	80/212 - (37%)
Similarity:	118/212 - (55%)	Gaps:	7/212 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 EGDMVPSGSSRNIWRNETYRWPNRIIYYHINSYIDEEHRNHIVSAIQKIESISCLTFKEATTDQK 101
            |||:....:.:|....:..|||:.|.|. :...::...:..|::|.::....:|:.|| ..:.:.
Mouse    52 EGDIKLEANGKNSIIGDHKRWPHTIPYV-LEDSLEMNAKGVILNAFERYRLKTCIDFK-PWSGEA 114

  Fly   102 YYVNVTSEEGGCFSYIGYLNRVQQLNLQNNEIGVGCFRLYTIVHEFLHALGFFHQQSAADRDDYV 166
            .|::| .:..||:|.:|.::    ...|...||..|.|:.|:.|||||||||:|:||.|||||||
Mouse   115 NYISV-FKGSGCWSSVGNIH----AGKQELSIGTNCDRIATVQHEFLHALGFWHEQSRADRDDYV 174

  Fly   167 QIVEENITEGMEFNFDKYTEETVNDFGEKYDYGSVMHYGPYAFSKNGERTILALEEGKEDVIGQR 231
            .||.:.|..|.|.||:.|.:...:.....|||.|||||...||....|.||:......|||||||
Mouse   175 IIVWDRIQPGKEHNFNIYNDSVSDSLNVPYDYTSVMHYSKTAFQNGTESTIVTRISEFEDVIGQR 239

  Fly   232 LELSETDIRKLNAIYKC 248
            ::.|:.|:.|||.:|.|
Mouse   240 MDFSDYDLLKLNQLYNC 256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15253	NP_609758.1	Astacin	55..250	CDD:279708	76/194 (39%)
CG15253	NP_609758.1	ZnMc_astacin_like	59..246	CDD:239807	71/186 (38%)
Mep1b	NP_032612.2	ZnMc	30..256	CDD:294052	79/210 (38%)
		Astacin	70..258	CDD:279708	76/194 (39%)
		MAM	266..430	CDD:279023
		MAM	266..428	CDD:99706
		MATH	428..587	CDD:295307
		EGF_CA	609..647	CDD:238011
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6346
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.860