DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15254 and mep1a.2

DIOPT Version :9

Sequence 1:	NP_001285959.1	Gene:	CG15254 / 34915	FlyBaseID:	FBgn0028949	Length:	254	Species:	Drosophila melanogaster
Sequence 2:	NP_001122199.1	Gene:	mep1a.2 / 565535	ZFINID:	ZDB-GENE-041001-208	Length:	689	Species:	Danio rerio

Alignment Length:	266	Identity:	86/266 - (32%)
Similarity:	136/266 - (51%)	Gaps:	35/266 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 WALTLVVIFLASSCSAAPT-----------TQNRIETDPELTAGYIEGDMVPSPEGRNGLRNETF 57
            |.::|..:.||....|.|.           .::.:|.:.:......|||:...|. ||.:.:|..
Zfish     5 WRISLFFVLLALKACALPAQYGEDADAGELREDILEINLDSQRELFEGDIAGDPR-RNAIIDEKA 68

  Fly    58 RWPNRIVYYYINRDIDTEHRNHILRGIRIIEQSSCLVFK----EATTDQEYYVNVTSEAGGCYSY 118
            ||...|. |.:...:|...:..||:.:.:....||:.||    |:|     |::.| :..||:|:
Zfish    69 RWQFPIP-YILTDTLDLNAKGVILQALEMYRLKSCVDFKPYEGEST-----YISFT-KLDGCWSF 126

  Fly   119 VGYRNRVQQLNLQT---YALDTGCFRLGTIVHEFLHALGFYHQQSTWNRDDYVRIAEENITEGTE 180
            ||        :|:|   .::...|.....:.||.||||||||:||..:|||||:|..:.|.||.|
Zfish   127 VG--------DLKTGQNVSIGERCDTKAIVEHELLHALGFYHEQSRSDRDDYVKIWWDQIIEGKE 183

  Fly   181 GNFNKYDNETVEDYGEPYDYSSVLHYTAYAFSKNGEM-TIVPLQEGAEELMGQRLQMTQSDINKL 244
            .|||||:::.:.|...||||.|::||...:|:|:.:: ||.........::||||..:..|:.:|
Zfish   184 HNFNKYEDDFITDLNTPYDYESIMHYRPLSFNKDPDIPTITTTIPAFNNIIGQRLDFSALDLERL 248

  Fly   245 NVMYKC 250
            |.||:|
Zfish   249 NRMYEC 254

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15254	NP_001285959.1	Astacin	58..251	CDD:279708	72/201 (36%)
CG15254	NP_001285959.1	ZnMc_astacin_like	61..248	CDD:239807	67/194 (35%)
mep1a.2	NP_001122199.1	ZnMc	26..254	CDD:294052	79/243 (33%)
		Astacin	68..256	CDD:279708	72/202 (36%)
		MAM	259..423	CDD:214533
		MAM	264..423	CDD:99706
		MATH	423..579	CDD:295307
		EGF	619..653	CDD:278437
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm25214
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910