DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15254 and MEP1B

DIOPT Version :9

Sequence 1:	NP_001285959.1	Gene:	CG15254 / 34915	FlyBaseID:	FBgn0028949	Length:	254	Species:	Drosophila melanogaster
Sequence 2:	NP_005916.2	Gene:	MEP1B / 4225	HGNCID:	7020	Length:	701	Species:	Homo sapiens

Alignment Length:	257	Identity:	87/257 - (33%)
Similarity:	133/257 - (51%)	Gaps:	17/257 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TWALTLVVIFLASSCSAAPTT--------QNRIETDPELTAGYIEGDM-VPSPEGRNGLRNETFR 58
            :|.|.|..:.:.|.. |.|..        |:..:.:..|.....|||: :...:.||.:..|.:|
Human     7 SWFLFLDALLVISGL-ATPENFDVDGGMDQDIFDINEGLGLDLFEGDIRLDRAQIRNSIIGEKYR 70

  Fly    59 WPNRIVYYYINRDIDTEHRNHILRGIRIIEQSSCLVFKEATTDQEYYVNVTSEAGGCYSYVGYRN 123
            ||:.|. |.:...::...:..||.........:|:.|| ....:..|::| .:..||:|.||.|
Human    71 WPHTIP-YVLEDSLEMNAKGVILNAFERYRLKTCIDFK-PWAGETNYISV-FKGSGCWSSVGNR- 131

  Fly   124 RVQQLNLQTYALDTGCFRLGTIVHEFLHALGFYHQQSTWNRDDYVRIAEENITEGTEGNFNKYDN 188
               ::..|..::...|.|:.|:.|||||||||:|:||..:|||||||..:.|..|.|.|||.|.:
Human   132 ---RVGKQELSIGANCDRIATVQHEFLHALGFWHEQSRSDRDDYVRIMWDRILSGREHNFNTYSD 193

  Fly   189 ETVEDYGEPYDYSSVLHYTAYAFSKNGEMTIVPLQEGAEELMGQRLQMTQSDINKLNVMYKC 250
            :..:....||||:||:||:..||....|.|||......|:::|||:..:.||:.|||.:|.|
Human   194 DISDSLNVPYDYTSVMHYSKTAFQNGTEPTIVTRISDFEDVIGQRMDFSDSDLLKLNQLYNC 255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15254	NP_001285959.1	Astacin	58..251	CDD:279708	73/193 (38%)
CG15254	NP_001285959.1	ZnMc_astacin_like	61..248	CDD:239807	68/186 (37%)
MEP1B	NP_005916.2	ZnMc_meprin	26..255	CDD:239809	80/235 (34%)
		Astacin	69..257	CDD:279708	73/194 (38%)
		MAM	260..427	CDD:214533
		MAM	265..427	CDD:99706
		MATH	427..586	CDD:295307
		Required for proteolytic processing	595..607
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910