DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15254 and MEP1A

DIOPT Version :9

Sequence 1:	NP_001285959.1	Gene:	CG15254 / 34915	FlyBaseID:	FBgn0028949	Length:	254	Species:	Drosophila melanogaster
Sequence 2:	XP_011512930.1	Gene:	MEP1A / 4224	HGNCID:	7015	Length:	774	Species:	Homo sapiens

Alignment Length:	221	Identity:	77/221 - (34%)
Similarity:	115/221 - (52%)	Gaps:	12/221 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 LTAG--YIEGDMVPSPEGRNGLRNETFRWPNRIVYYYINRDIDTEHRNHILRGIRIIEQSSCLVF 95
            |.||  ..:||:: ..:.|||||:...||...|.|...: ::....:..||....:....||:.|
Human    76 LAAGLDLFQGDIL-LQKSRNGLRDPNTRWTFPIPYILAD-NLGLNAKGAILYAFEMFRLKSCVDF 138

  Fly    96 KEATTDQEYYVNVTSEAGGCYSYVGYRNRVQQLNLQTYALDTGCFRLGTIVHEFLHALGFYHQQS 160
            |....:..|.  :..:..||:|.||.::..|.:     ::..||.....|.||.||||||||:||
Human   139 KPYEGESSYI--IFQQFDGCWSEVGDQHVGQNI-----SIGQGCAYKAIIEHEILHALGFYHEQS 196

  Fly   161 TWNRDDYVRIAEENITEGTEGNFNKYDNETVEDYGEPYDYSSVLHYTAYAFSKNGEM-TIVPLQE 224
            ..:|||||.|..:.|..|.:.||:.||:..:.|...||||.|::||..::|:||..: ||.....
Human   197 RTDRDDYVNIWWDQILSGYQHNFDTYDDSLITDLNTPYDYESLMHYQPFSFNKNASVPTITAKIP 261

  Fly   225 GAEELMGQRLQMTQSDINKLNVMYKC 250
            ....::||||..:..|:.:||.||.|
Human   262 EFNSIIGQRLDFSAIDLERLNRMYNC 287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15254	NP_001285959.1	Astacin	58..251	CDD:279708	67/194 (35%)
CG15254	NP_001285959.1	ZnMc_astacin_like	61..248	CDD:239807	62/187 (33%)
MEP1A	XP_011512930.1	ZnMc_meprin	58..287	CDD:239809	76/219 (35%)
		Astacin	101..289	CDD:279708	67/195 (34%)
		MAM	292..459	CDD:214533
		MAM	297..459	CDD:99706
		MATH_Meprin_Alpha	459..622	CDD:239752
		EGF_CA	700..738	CDD:238011
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910