DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15254 and Mep1b

DIOPT Version :9

Sequence 1:	NP_001285959.1	Gene:	CG15254 / 34915	FlyBaseID:	FBgn0028949	Length:	254	Species:	Drosophila melanogaster
Sequence 2:	NP_032612.2	Gene:	Mep1b / 17288	MGIID:	96964	Length:	704	Species:	Mus musculus

Alignment Length:	260	Identity:	84/260 - (32%)
Similarity:	126/260 - (48%)	Gaps:	24/260 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 WALTLVVIFLASSCSA---------APTTQNRIETDPELTAGYIEGDMVPSPEGRNGLRNETFRW 59
            |.|......|.|...|         ....|:..:.:..|.....|||:.....|:|.:..:..||
Mouse     8 WFLVFATFLLVSGLPAPEKFVKDIDGGIDQDIFDINQGLGLDLFEGDIKLEANGKNSIIGDHKRW 72

  Fly    60 PNRIVYYYINRDIDTEHRNHILRGIRIIEQSSCLVFKEATTDQEYYVNVTSEAGGCYSYVGYRNR 124
            |:.|. |.:...::...:..||.........:|:.|| ..:.:..|::| .:..||:|.||
Mouse    73 PHTIP-YVLEDSLEMNAKGVILNAFERYRLKTCIDFK-PWSGEANYISV-FKGSGCWSSVG---- 130

  Fly   125 VQQLNL----QTYALDTGCFRLGTIVHEFLHALGFYHQQSTWNRDDYVRIAEENITEGTEGNFNK 185
                |:    |..::.|.|.|:.|:.|||||||||:|:||..:|||||.|..:.|..|.|.|||.
Mouse   131 ----NIHAGKQELSIGTNCDRIATVQHEFLHALGFWHEQSRADRDDYVIIVWDRIQPGKEHNFNI 191

  Fly   186 YDNETVEDYGEPYDYSSVLHYTAYAFSKNGEMTIVPLQEGAEELMGQRLQMTQSDINKLNVMYKC 250
            |::...:....||||:||:||:..||....|.|||......|:::|||:..:..|:.|||.:|.|
Mouse   192 YNDSVSDSLNVPYDYTSVMHYSKTAFQNGTESTIVTRISEFEDVIGQRMDFSDYDLLKLNQLYNC 256

Fly 251 250
Mouse 257 256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15254	NP_001285959.1	Astacin	58..251	CDD:279708	72/197 (37%)
CG15254	NP_001285959.1	ZnMc_astacin_like	61..248	CDD:239807	67/190 (35%)
Mep1b	NP_032612.2	ZnMc	30..256	CDD:294052	78/236 (33%)
		Astacin	70..258	CDD:279708	72/198 (36%)
		MAM	266..430	CDD:279023
		MAM	266..428	CDD:99706
		MATH	428..587	CDD:295307
		EGF_CA	609..647	CDD:238011
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910