DRSC/TRiP Functional Genomics Resources

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Protein Alignment Semp1 and TLL2

DIOPT Version :9

Sequence 1:NP_609756.1 Gene:Semp1 / 34914 FlyBaseID:FBgn0028944 Length:251 Species:Drosophila melanogaster
Sequence 2:NP_036597.1 Gene:TLL2 / 7093 HGNCID:11844 Length:1015 Species:Homo sapiens


Alignment Length:201 Identity:65/201 - (32%)
Similarity:105/201 - (52%) Gaps:15/201 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly    53 WPNRTVPYMIEDDAFADSHYREILRAISIIEENSCVIFKPATEMDFPMALVITSKGLGCNTVHLG 117
            ||...:||:|..: |..|......:|:...|:::||.|...|  |....:|.:.:..||.: ::|
Human   159 WPGGVIPYVIGGN-FTGSQRAIFKQAMRHWEKHTCVTFIERT--DEESFIVFSYRTCGCCS-YVG 219

  Fly   118 YR-NKTQVVNLEIYPLGEGCFRIGSIIHELLHVLGFEHQHVSQNRDQYVSIQWKNINPQYNINFV 181
            .| ...|.::     :|:.|.:.|.:.|||.||:||.|:|...:|||:|:|..:||.|....||:
Human   220 RRGGGPQAIS-----IGKNCDKFGIVAHELGHVVGFWHEHTRPDRDQHVTIIRENIQPGQEYNFL 279

  Fly   182 NNDNSTAWHDFDEGYDYESVMHYVPRAFSRN-GQPTIVPLREG---AENMGQRFYMSEKDIRKLN 242
            ..:.... ....|.||::|:|||....|||. ...||:|.::.   ...:|||..:|:.||.:..
Human   280 KMEAGEV-SSLGETYDFDSIMHYARNTFSRGVFLDTILPRQDDNGVRPTIGQRVRLSQGDIAQAR 343

  Fly   243 KMYRCP 248
            |:|:||
Human   344 KLYKCP 349

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Semp1NP_609756.1 Astacin 53..249 CDD:279708 65/201 (32%)
ZnMc_astacin_like 55..245 CDD:239807 60/194 (31%)
TLL2NP_036597.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 24..49
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 88..130
ZnMc_BMP1_TLD 150..349 CDD:239808 63/199 (32%)
Astacin 157..350 CDD:279708 65/201 (32%)
CUB 351..460 CDD:278839
CUB 464..573 CDD:278839
FXa_inhibition 584..616 CDD:291342
CUB 620..729 CDD:278839
FXa_inhibition 736..771 CDD:291342
CUB 776..885 CDD:278839
CUB 889..1002 CDD:278839
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3714
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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