DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Semp1 and TLL1

DIOPT Version :9

Sequence 1:	NP_609756.1	Gene:	Semp1 / 34914	FlyBaseID:	FBgn0028944	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	NP_036596.3	Gene:	TLL1 / 7092	HGNCID:	11843	Length:	1013	Species:	Homo sapiens

Alignment Length:	204	Identity:	69/204 - (33%)
Similarity:	109/204 - (53%)	Gaps:	21/204 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 WPNRTVPYMIEDDAFADSHYREILRAISIIEENSCVIFKPATEMDFPMALVITSKGLGCNTVHLG 117
            ||...:||:|..: |..|......:|:...|:::||.|  ....|....:|.|.:..||.: ::|
Human   157 WPGGVIPYVIGGN-FTGSQRAMFKQAMRHWEKHTCVTF--IERSDEESYIVFTYRPCGCCS-YVG 217

  Fly   118 YR-NKTQVVNLEIYPLGEGCFRIGSIIHELLHVLGFEHQHVSQNRDQYVSIQWKNINPQYNINFV 181
            .| |..|.::     :|:.|.:.|.::|||.||:||.|:|...:||.:|:|..:||.|....||:
Human   218 RRGNGPQAIS-----IGKNCDKFGIVVHELGHVIGFWHEHTRPDRDNHVTIIRENIQPGQEYNFL 277

  Fly   182 NNDNSTAWHDFDEGYDYESVMHYVPRAFSRNGQ--PTIVPLREGAEN-----MGQRFYMSEKDIR 239
            ..:.... :...|.||::|:|||....||| |.  .||:|.|:  :|     :|||..:|:.||.
Human   278 KMEPGEV-NSLGERYDFDSIMHYARNTFSR-GMFLDTILPSRD--DNGIRPAIGQRTRLSKGDIA 338

  Fly   240 KLNKMYRCP 248
            :..|:||||
Human   339 QARKLYRCP 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Semp1	NP_609756.1	Astacin	53..249	CDD:279708	69/204 (34%)
Semp1	NP_609756.1	ZnMc_astacin_like	55..245	CDD:239807	63/197 (32%)
TLL1	NP_036596.3	ZnMc_BMP1_TLD	148..347	CDD:239808	67/202 (33%)
		Astacin	155..348	CDD:279708	69/204 (34%)
		CUB	349..458	CDD:278839
		CUB	462..571	CDD:278839
		FXa_inhibition	582..614	CDD:291342
		CUB	618..727	CDD:278839
		FXa_inhibition	734..769	CDD:291342
		CUB	774..883	CDD:278839
		CUB	887..1000	CDD:278839
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810