DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Semp1 and astl2c

DIOPT Version :9

Sequence 1:	NP_609756.1	Gene:	Semp1 / 34914	FlyBaseID:	FBgn0028944	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	NP_001037864.1	Gene:	astl2c / 594901	XenbaseID:	XB-GENE-6449741	Length:	496	Species:	Xenopus tropicalis

Alignment Length:	248	Identity:	82/248 - (33%)
Similarity:	122/248 - (49%)	Gaps:	40/248 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 VFSELFKDPELLAGFY-QGDIKAHPI-------------RTRNGIVNQIYHWPNRTVPYMIEDDA 66
            ||..:.:..:....|: |||| ||..             :..|||||         |||.|..|
Frog    43 VFGRILRANKGKRNFHVQGDI-AHKFSRSAINCKECLWPKDSNGIVN---------VPYTISSD- 96

  Fly    67 FADSHYREILRAISIIEENSCVIFKPATEMDFPMALVITSKGLGCNTVHLGYRNKTQVVNLEIYP 131
            ::.:....|:.|:......:||.|.|.|:.|..:|:....   ||.: ::|.....|.|:
Frog    97 YSQNEASLIMAAMQEFATLTCVQFIPQTDEDDYIAIQPLD---GCWS-YIGVNGGAQQVS----- 152

  Fly   132 LGE-GCFRIGSIIHELLHVLGFEHQHVSQNRDQYVSIQWKNINPQYNINFVNNDNSTAWHDFDEG 195
            ||: ||...|.|.|||.|||||.|:|...:||.||.|.::.|:|. ||.|.:..::   .:....
Frog   153 LGKGGCIYYGVIQHELNHVLGFVHEHSRSDRDNYVHINYQYISPD-NIAFFDKKDT---DNLGLE 213

  Fly   196 YDYESVMHYVPRAFSR-NGQPTIVPLREGAENMGQRFYMSEKDIRKLNKMYRC 247
            |||.|||||...::|. .|:.||||:......:|||:.:|..|:.|:|::|:|
Frog   214 YDYSSVMHYPGYSYSNTTGKNTIVPIPNANVPIGQRYGLSTLDVSKINRLYQC 266

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Semp1	NP_609756.1	Astacin	53..249	CDD:279708	68/197 (35%)
Semp1	NP_609756.1	ZnMc_astacin_like	55..245	CDD:239807	66/191 (35%)
astl2c	NP_001037864.1	ZnMc_hatching_enzyme	84..266	CDD:239810	72/204 (35%)
		Astacin	89..266	CDD:279708	67/190 (35%)
		CUB	270..380	CDD:238001
		CUB	383..495	CDD:238001
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000