DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Semp1 and mep1a.1

DIOPT Version :9

Sequence 1:	NP_609756.1	Gene:	Semp1 / 34914	FlyBaseID:	FBgn0028944	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	NP_001025452.1	Gene:	mep1a.1 / 553530	ZFINID:	ZDB-GENE-041001-209	Length:	598	Species:	Danio rerio

Alignment Length:	222	Identity:	81/222 - (36%)
Similarity:	109/222 - (49%)	Gaps:	24/222 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 QGDIKAHPIRTRNGIVNQIYHWPNRTVPYMIEDDAFADSHYREILRAISIIEENSCVIFKP---- 92
            :|||...|  .|.|::|..|.| ...:||::.|....::. ..|.:|..:....|||.|||
Zfish    48 EGDIALPP--GRIGLINTTYRW-KFPIPYILSDSLDLNAK-GAIYQAFEVYRLKSCVDFKPYEGE 108

  Fly    93 ATEMDFPMALVITSKGLGCNTVHLGYRNKTQVVNLEIYPLGEGCFRIGSIIHELLHVLGFEHQHV 157
            .|.:.|       .||.||.: .:|.:...||::     ||.||.....|.|||||.|||.|...
Zfish   109 KTYIKF-------EKGDGCWS-FVGDQQNGQVLS-----LGPGCDHKAVIEHELLHALGFYHMQS 160

  Fly   158 SQNRDQYVSIQWKNINPQYNINFVNNDNSTAWHDFDEGYDYESVMHYVPRAFSRNGQ-PTIVP-L 220
            .|:||.||.|....:......||...|:|.. .|.:..|||||||||.|.||:::.. |||.. :
Zfish   161 RQDRDDYVKIWLDQVIEGLEHNFNKYDDSFV-TDLNTPYDYESVMHYRPFAFNKDPSIPTITTNI 224

  Fly   221 REGAENMGQRFYMSEKDIRKLNKMYRC 247
            .|..:.:||....||.||.:||:||.|
Zfish   225 PEFYKIIGQYLDFSEMDIVRLNRMYNC 251

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Semp1	NP_609756.1	Astacin	53..249	CDD:279708	73/201 (36%)
Semp1	NP_609756.1	ZnMc_astacin_like	55..245	CDD:239807	69/195 (35%)
mep1a.1	NP_001025452.1	ZnMc	26..251	CDD:294052	80/220 (36%)
		Astacin	65..253	CDD:279708	74/203 (36%)
		MAM	261..420	CDD:279023
		MAM	261..419	CDD:99706
		MATH	419..582	CDD:295307
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010