DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Semp1 and tll1

DIOPT Version :9

Sequence 1:	NP_609756.1	Gene:	Semp1 / 34914	FlyBaseID:	FBgn0028944	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	NP_001008039.1	Gene:	tll1 / 493401	XenbaseID:	XB-GENE-479941	Length:	495	Species:	Xenopus tropicalis

Alignment Length:	255	Identity:	81/255 - (31%)
Similarity:	122/255 - (47%)	Gaps:	33/255 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 PTVFSELFKDP---ELLAGFYQGDIKAHPIR---------TRNGIVNQIYHWPNRT-----VPYM 61
            ||..|:..|||   .|.....:.:.|:..:|         .||.|......||..:     |||.
Frog    27 PTPKSQDGKDPADNNLYTDIMKANQKSKKLRIHGDIALKTDRNAINCTECLWPKSSDGFVYVPYT 91

  Fly    62 IEDDAFADSHYREILRAISIIEENSCVIFKPAT-EMDFPMALVITSKGLGCNTVHLGYRNKTQVV 125
            :..| ::......|..|:...|..:||.|.|.| |.|:   |.|.|.. ||.: ::||...:|.|
Frog    92 VSSD-YSQDEVNAITTAMKEYEGLTCVQFTPWTGEDDY---LAIQSLD-GCWS-YIGYYGGSQAV 150

  Fly   126 NLEIYPLGEGCFRIGSIIHELLHVLGFEHQHVSQNRDQYVSIQWKNINPQYNINFVNNDNSTAWH 190
            :|    |...|...|.:.|||.|.|||.|:|...:||.||:|.::.|:|:.    :.|.:..:.:
Frog   151 SL----LKGFCAYNGGVQHELNHALGFYHEHNRSDRDDYVTIMYQYISPEN----IGNFDKISTN 207

  Fly   191 DFDEGYDYESVMHYVPRAFSR-NGQPTIVPLREGAENMGQRFYMSEKDIRKLNKMYRCPD 249
            :....|||.|::||...|||. :||.||||.......:||.:.:|..|:.|:|::|.|.:
Frog   208 NLGVDYDYSSILHYAGNAFSNTSGQNTIVPHPNPNVPIGQSYGLSNLDVLKINRLYGCDE 267

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Semp1	NP_609756.1	Astacin	53..249	CDD:279708	69/202 (34%)
Semp1	NP_609756.1	ZnMc_astacin_like	55..245	CDD:239807	65/196 (33%)
tll1	NP_001008039.1	ZnMc_hatching_enzyme	83..265	CDD:239810	66/195 (34%)
		CUB	269..379	CDD:238001
		CUB	382..494	CDD:238001
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910