DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Semp1 and Nrx-1

DIOPT Version :9

Sequence 1:	NP_609756.1	Gene:	Semp1 / 34914	FlyBaseID:	FBgn0028944	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	NP_001262840.1	Gene:	Nrx-1 / 42646	FlyBaseID:	FBgn0038975	Length:	1847	Species:	Drosophila melanogaster

Alignment Length:	175	Identity:	41/175 - (23%)
Similarity:	71/175 - (40%)	Gaps:	43/175 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 YHWPNR--TVPYMIEDDAFADSHYREILRAISIIEENSCVIF---KPATEMDFPMALVITSKGLG 110
            |.:.|.  .|.|...::|.||:....|  |:..|......:.   :.||..|: |.|.|..
  Fly  1203 YEFGNNKGMVQYTFPENAQADTEEDNI--ALGFITTRPDAVLLRVESATTQDY-MELEIVE---- 1260

  Fly   111 CNTVHLGYRNKTQVVNLEIYPLGEGCFRIGSIIHE-LLHVLGFEHQ--HVSQNRDQYVSIQWKNI 172
             ..:.:.|    .:.:::: ||||    ||:.::: ..||:.|:.:  :.:...|.| ::|  .:
  Fly  1261 -GNIFMVY----NIGSVDL-PLGE----IGTKVNDNAYHVVRFQRKGGNATLQLDDY-NVQ--AL 1312

  Fly   173 NPQYNINFVNNDNSTAWHDFDEGYDYESVMHYVPRAFSRNGQPTI 217
            .||.:.:.|.|..|..               .|...|||||:..|
  Fly  1313 TPQSHHSTVFNTMSNV---------------QVGGKFSRNGRNRI 1342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Semp1	NP_609756.1	Astacin	53..249	CDD:279708	40/173 (23%)
Semp1	NP_609756.1	ZnMc_astacin_like	55..245	CDD:239807	40/171 (23%)
Nrx-1	NP_001262840.1	LamG	110..263	CDD:238058
		EGF_CA	311..347	CDD:238011
		Laminin_G_2	386..517	CDD:280389
		LamG	555..716	CDD:238058
		EGF	746..777	CDD:278437
		Laminin_G_2	814..945	CDD:280389
		LamG	988..1136	CDD:238058
		EGF	1164..1195	CDD:278437
		Laminin_G_2	1233..1356	CDD:280389	32/143 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444839
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930