DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Semp1 and MEP1B

DIOPT Version :9

Sequence 1:	NP_609756.1	Gene:	Semp1 / 34914	FlyBaseID:	FBgn0028944	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	NP_005916.2	Gene:	MEP1B / 4225	HGNCID:	7020	Length:	701	Species:	Homo sapiens

Alignment Length:	267	Identity:	87/267 - (32%)
Similarity:	131/267 - (49%)	Gaps:	38/267 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IWGVI-FLF-----------TPTVF-------SELFKDPELLA-GFYQGDIKAHPIRTRNGIVNQ 49
            :|.:. |||           ||..|       .::|...|.|. ..::|||:....:.||.|:.:
Human     3 LWNLSWFLFLDALLVISGLATPENFDVDGGMDQDIFDINEGLGLDLFEGDIRLDRAQIRNSIIGE 67

  Fly    50 IYHWPNRTVPYMIEDDAFADSHYREILRAISIIEENSCVIFKP-ATEMDFPMALVITSKGLGCNT 113
            .|.||: |:||::||....::. ..||.|.......:|:.||| |.|.::    :...||.||.:
Human    68 KYRWPH-TIPYVLEDSLEMNAK-GVILNAFERYRLKTCIDFKPWAGETNY----ISVFKGSGCWS 126

  Fly   114 VHLGYRNKTQVVNLEIYPLGEGCFRIGSIIHELLHVLGFEHQHVSQNRDQYVSIQWKNI--NPQY 176
             .:|.|.    |..:...:|..|.||.::.||.||.|||.|:....:||.||.|.|..|  ..::
Human   127 -SVGNRR----VGKQELSIGANCDRIATVQHEFLHALGFWHEQSRSDRDDYVRIMWDRILSGREH 186

  Fly   177 NINFVNNDNSTAWHDFDEGYDYESVMHYVPRAFSRNGQPTIVP-LREGAENMGQRFYMSEKDIRK 240
            |.|..::|.|.:   .:..|||.|||||...||....:||||. :.:..:.:|||...|:.|:.|
Human   187 NFNTYSDDISDS---LNVPYDYTSVMHYSKTAFQNGTEPTIVTRISDFEDVIGQRMDFSDSDLLK 248

  Fly   241 LNKMYRC 247
            ||::|.|
Human   249 LNQLYNC 255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Semp1	NP_609756.1	Astacin	53..249	CDD:279708	70/199 (35%)
Semp1	NP_609756.1	ZnMc_astacin_like	55..245	CDD:239807	66/193 (34%)
MEP1B	NP_005916.2	ZnMc_meprin	26..255	CDD:239809	80/242 (33%)
		Astacin	69..257	CDD:279708	71/201 (35%)
		MAM	260..427	CDD:214533
		MAM	265..427	CDD:99706
		MATH	427..586	CDD:295307
		Required for proteolytic processing	595..607
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910