DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Semp1 and MEP1A

DIOPT Version :9

Sequence 1:	NP_609756.1	Gene:	Semp1 / 34914	FlyBaseID:	FBgn0028944	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	XP_011512930.1	Gene:	MEP1A / 4224	HGNCID:	7015	Length:	774	Species:	Homo sapiens

Alignment Length:	239	Identity:	82/239 - (34%)
Similarity:	116/239 - (48%)	Gaps:	32/239 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LLAG--FYQGDIKAHPIRTRNGIVNQIYHWPNRTVPYMIEDDAFADSHYREILRAISIIEENSCV 88
            |.||  .:||||...  ::|||:.:....| ...:||::.|:...::. ..||.|..:....|||
Human    76 LAAGLDLFQGDILLQ--KSRNGLRDPNTRW-TFPIPYILADNLGLNAK-GAILYAFEMFRLKSCV 136

  Fly    89 IFKPATEMDFPMALVITSKGLGC----NTVHLGYRNKTQVVNLEIYPLGEGCFRIGSIIHELLHV 149
            .|||   .:...:.:|..:..||    ...|:|.       |:.|   |:||.....|.||:||.
Human   137 DFKP---YEGESSYIIFQQFDGCWSEVGDQHVGQ-------NISI---GQGCAYKAIIEHEILHA 188

  Fly   150 LGFEHQHVSQNRDQYVSIQWKNINPQYNINFVNNDNSTAWHDFDEGYDYESVMHYVPRAFSRNGQ 214
            |||.|:....:||.||:|.|..|...|..||...|:|.. .|.:..|||||:|||.|.:|::|..
Human   189 LGFYHEQSRTDRDDYVNIWWDQILSGYQHNFDTYDDSLI-TDLNTPYDYESLMHYQPFSFNKNAS 252

  Fly   215 -PTI-VPLREGAENMGQRFYMSEKDIRKLNKMYRCP------DH 250
             ||| ..:.|....:|||...|..|:.:||:||.|.      ||
Human   253 VPTITAKIPEFNSIIGQRLDFSAIDLERLNRMYNCTTTHTLLDH 296

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Semp1	NP_609756.1	Astacin	53..249	CDD:279708	70/207 (34%)
Semp1	NP_609756.1	ZnMc_astacin_like	55..245	CDD:239807	66/195 (34%)
MEP1A	XP_011512930.1	ZnMc_meprin	58..287	CDD:239809	79/228 (35%)
		Astacin	101..289	CDD:279708	70/203 (34%)
		MAM	292..459	CDD:214533	2/5 (40%)
		MAM	297..459	CDD:99706	82/239 (34%)
		MATH_Meprin_Alpha	459..622	CDD:239752
		EGF_CA	700..738	CDD:238011
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910