DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Semp1 and Astl

DIOPT Version :9

Sequence 1:	NP_609756.1	Gene:	Semp1 / 34914	FlyBaseID:	FBgn0028944	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	NP_001099974.1	Gene:	Astl / 296129	RGDID:	1562279	Length:	436	Species:	Rattus norvegicus

Alignment Length:	233	Identity:	82/233 - (35%)
Similarity:	120/233 - (51%)	Gaps:	35/233 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 QGD-IKAHPIRTRNGIVNQIYHWPNRTVPYMIEDDAFADSHYRE-----ILRAISIIEENSCVIF 90
            :|| |:..|.|..:...|:   || :.|..::|......|.|.|     |:.|.:..|..:|:.|
  Rat    75 EGDIIRPSPFRLLSVTNNK---WP-KGVDGIVEIPFLLSSKYDEPSRQVIMEAFAEFERFTCIRF 135

  Fly    91 KP-ATEMDF----PMALVITSKGLGCNTVHLGYRNKTQVVNLEIYPLGEGCFRIGSIIHELLHVL 150
            .. ..:.||    |||        ||.: .:|.....|||:|....|.:|   .|.::|||:|||
  Rat   136 VAYRGQRDFVSILPMA--------GCFS-GVGRSGGMQVVSLAPTCLQKG---RGIVLHELMHVL 188

  Fly   151 GFEHQHVSQNRDQYVSIQWKNINPQYNINFVNNDNSTAWHDFDEGYDYESVMHYVPRAFSRNGQP 215
            ||.|:|...:||:|:.:.|..|.|.:.|||:.:.||    :....|||.|||||...|||..|||
  Rat   189 GFWHEHSRADRDRYIRVNWNEILPGFEINFIKSRNS----NMLAPYDYSSVMHYGRFAFSWRGQP 249

  Fly   216 TIVPLREGAENMGQRFYMSEKDIRKLNKMYRC----PD 249
            ||:||...:.::|||:.:|..||.::.::|.|    ||
  Rat   250 TIIPLWTSSVHIGQRWNLSTSDITRVCRLYSCSPSVPD 287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Semp1	NP_609756.1	Astacin	53..249	CDD:279708	74/209 (35%)
Semp1	NP_609756.1	ZnMc_astacin_like	55..245	CDD:239807	70/199 (35%)
Astl	NP_001099974.1	Astacin	92..283	CDD:279708	75/210 (36%)
		ZnMc	99..281	CDD:294052	70/197 (36%)
		ImpA_N	<305..420	CDD:303075
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D472790at33208
OrthoFinder	1	1.000	-	-		FOG0000240
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920