DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Semp1 and Astl

DIOPT Version :9

Sequence 1:	NP_609756.1	Gene:	Semp1 / 34914	FlyBaseID:	FBgn0028944	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	NP_001277932.1	Gene:	Astl / 215095	MGIID:	3046414	Length:	435	Species:	Mus musculus

Alignment Length:	269	Identity:	84/269 - (31%)
Similarity:	130/269 - (48%)	Gaps:	54/269 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 FTPTVFSELFKDPELLA--------------GFYQGD-IKAHPIRTRNGIVNQIYHWPNRT---- 57
            |||. .|.:|:|.::.|              ...:|| |:..|.|..:...|:   ||...
Mouse    42 FTPE-GSPVFQDKDIPAINQGLISEETPESSFLVEGDIIRPSPFRLLSVTNNK---WPKGVGGFV 102

  Fly    58 -VPYMIEDDAFADSHYREILRAISIIEENSCVIFKP-ATEMDF----PMALVITSKGLGCNTVHL 116
             :|::: ...:.:...|.|:.|.:..|..:|:.|.. ..:.||    |||        ||.: .:
Mouse   103 EIPFLL-SRKYDELSRRVIMDAFAEFERFTCIRFVAYHGQRDFVSILPMA--------GCFS-GV 157

  Fly   117 GYRNKTQVVNLEIYPLGEGCFRIGS--IIHELLHVLGFEHQHVSQNRDQYVSIQWKNINPQYNIN 179
            |.....|||:     |...|.|.|.  ::|||:|||||.|:|...:||:|:.:.|..|.|.:.||
Mouse   158 GRSGGMQVVS-----LAPTCLRKGRGIVLHELMHVLGFWHEHSRADRDRYIQVNWNEILPGFEIN 217

  Fly   180 FVNNDNSTAWHDFDEGYDYESVMHYVPRAFSRNGQPTIVPLREGAENMGQRFYMSEKDIRKLNKM 244
            |:.:.::    :....|||.|||||...|||..|||||:||...:.::|||:.:|..||.::.::
Mouse   218 FIKSRST----NMLVPYDYSSVMHYGRFAFSWRGQPTIIPLWTSSVHIGQRWNLSTSDITRVCRL 278

  Fly   245 YRC----PD 249
            |.|    ||
Mouse   279 YNCSRSVPD 287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Semp1	NP_609756.1	Astacin	53..249	CDD:279708	69/211 (33%)
Semp1	NP_609756.1	ZnMc_astacin_like	55..245	CDD:239807	65/201 (32%)
Astl	NP_001277932.1	Astacin	92..282	CDD:279708	69/211 (33%)
		ZnMc	100..281	CDD:294052	66/199 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	318..356
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5777
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000240
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.860