DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Semp1 and nas-27

DIOPT Version :9

Sequence 1:	NP_609756.1	Gene:	Semp1 / 34914	FlyBaseID:	FBgn0028944	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	NP_493926.2	Gene:	nas-27 / 188809	WormBaseID:	WBGene00003545	Length:	428	Species:	Caenorhabditis elegans

Alignment Length:	261	Identity:	68/261 - (26%)
Similarity:	108/261 - (41%)	Gaps:	30/261 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VIFLFTPTVFSELFKDP--------------ELLAG----FYQGDIKAHPIRTRNGIVNQIYHWP 54
            ::.:|.|.:.:.|...|              ..|.|    .|||||.....|.|..::.|.:...
Worm     3 ILPIFFPLLITSLHAIPRGRRAVRNRNEGDINSLVGVGQYLYQGDIAVVKSRARRAVIRQKHKKW 67

  Fly    55 NRTVPYMIEDDAFADSHYREILRAISIIEENSCVIFKPATEMDFPMALVITSKGLGCNTVHLGYR 119
            ...:||.. |..|.....:.:|.|:....|.:||.|.   |..:....|...:|.||    ..:.
Worm    68 KLPMPYSF-DRNFPSRSRQRVLEAMQFWSEKTCVTFH---ENRYVYPHVSIFEGNGC----WSFV 124

  Fly   120 NKTQVVNLEIYPLGEGCFRIGSII-HELLHVLGFEHQHVSQNRDQYVSIQWKNINPQYNINFVNN 183
            .|...:..:...|...|.....:: ||:.|.|||.|:|...:|||::||.:.|:||.....|...
Worm   125 GKQPSLREQSLSLERSCTDHTFVVAHEIAHTLGFYHEHARGDRDQFISIDYSNVNPNLTFAFAKE 189

  Fly   184 DNSTAWHDFDEGYDYESVMHYVPRAFSRNGQPTIVPLREG--AENMGQRFYMSEKDIRKLNKMYR 246
            ......|. :..|:|.|||||....|:.|....::..|:.  |:.||.|...:.:|:.::|.:|.
Worm   190 SEKQLDHQ-EAAYEYGSVMHYSVDQFAVNTNRPVIYARDQKFAQAMGNRMRATFQDVSRMNVLYN 253

  Fly   247 C 247
            |
Worm   254 C 254

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Semp1	NP_609756.1	Astacin	53..249	CDD:279708	54/198 (27%)
Semp1	NP_609756.1	ZnMc_astacin_like	55..245	CDD:239807	52/192 (27%)
nas-27	NP_493926.2	Astacin	65..254	CDD:279708	53/197 (27%)
		ZnMc_astacin_like	70..252	CDD:239807	52/190 (27%)
		CUB	334..410	CDD:294042
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D681837at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920